Response to interferon therapy affects risk factors for postoperative recurrence of hepatitis C virus-related hepatocellular carcinoma

2008 ◽  
Vol 98 (5) ◽  
pp. 358-362 ◽  
Author(s):  
Takahiro Uenishi ◽  
Shuhei Nishiguchi ◽  
Shogo Tanaka ◽  
Takatsugu Yamamoto ◽  
Shigekazu Takemura ◽  
...  
2018 ◽  
Vol 12 (1) ◽  
pp. 26-32 ◽  
Author(s):  
Arnolfo Petruzziello

Introduction:Hepatocellular carcinoma (HCC) is one of the most prevalent primary malignant tumors and accounts for about 90% of all primary liver cancers. Its distribution varies greatly according to geographic location and it is more common in middle and low- income countries than in developed ones especially in Eastern Asia and Sub Saharan Africa (70% of all new HCCs worldwide), with incidence rates of over 20 per 100,000 individuals.Explanation:The most important risk factors for HCC are Hepatitis B Virus (HBV) infection, Hepatitis C Virus (HCV) infection, excessive consumption of alcohol and exposition to aflatoxin B1. Its geographic variability and heterogeneity have been widely associated with the different distribution of HBV and HCV infections worldwide.Chronic HBV infection is one of the leading risk factors for HCC globally accounting for at least 50% cases of primary liver tumors worldwide. Generally, while HBV is the main causative agent in the high incidence HCC areas, HCV is the major etiological factor in low incidence HCC areas, like Western Europe and North America.Conclusion:HBV-induced HCC is a complex, stepwise process that includes integration of HBV DNA into host DNA at multiple or single sites. On the contrary, the cancerogenesis mechanism of HCV is not completely known and it still remains controversial as to whether HCV itself plays a direct role in the development of tumorigenic progression.


2012 ◽  
Vol 56 (03) ◽  
pp. 235-240 ◽  
Author(s):  
E. SCHIEFELBEIN ◽  
A.-R. ZEKRI ◽  
D. W. NEWTON ◽  
G. A. SOLIMAN ◽  
M. BANERJEE ◽  
...  

2011 ◽  
Vol 46 (6) ◽  
pp. 799-808 ◽  
Author(s):  
Yuko Nagaoki ◽  
Hiroshi Aikata ◽  
Daisuke Miyaki ◽  
Eisuke Murakami ◽  
Yoshimasa Hashimoto ◽  
...  

2000 ◽  
Vol 24 (12) ◽  
pp. 1559-1565 ◽  
Author(s):  
Shoji Kubo ◽  
Kazuhiro Hirohashi ◽  
Hiromu Tanaka ◽  
Tadashi Tsukamoto ◽  
Taichi Shuto ◽  
...  

Oncology ◽  
2003 ◽  
Vol 65 (3) ◽  
pp. 204-210 ◽  
Author(s):  
Kenji Ikeda ◽  
Masahiro Kobayashi ◽  
Satoshi Saitoh ◽  
Takashi Someya ◽  
Tetsuya Hosaka ◽  
...  

2016 ◽  
Vol 63 (6) ◽  
pp. 821-829 ◽  
Author(s):  
Lars I. Gjærde ◽  
Leah Shepherd ◽  
Elzbieta Jablonowska ◽  
Adriano Lazzarin ◽  
Mathieu Rougemont ◽  
...  

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