Outcomes of microvascular flap reconstruction of the head and neck in patients receiving systemic immunosuppressive therapy for organ transplantation

2018 ◽  
Vol 117 (7) ◽  
pp. 1575-1583 ◽  
Author(s):  
Mark V. Schaverien ◽  
Riley A. Dean ◽  
Jeffrey N. Myers ◽  
Lin Fang ◽  
Rene D. Largo ◽  
...  
2005 ◽  
Vol 115 (8) ◽  
pp. 1391-1394 ◽  
Author(s):  
Jason Roostaeian ◽  
Jeffrey D. Suh ◽  
Joel A. Sercarz ◽  
Elliot Abemayor ◽  
Jivianne T. Lee ◽  
...  

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Vinay K. Shankhdhar ◽  
Mayur R. Mantri ◽  
Snehjeet Wagh ◽  
Shivakumar Thiagarajan ◽  
Devendra Chaukar ◽  
...  

1983 ◽  
Vol 10 (1) ◽  
pp. 73-83
Author(s):  
Stephen R. Colen ◽  
Daniel C. Baker ◽  
William W. Shaw

2020 ◽  
Vol 13 (12) ◽  
pp. e238614
Author(s):  
Ogonna N Nnamani Silva ◽  
Audrey B Nguyen ◽  
William Y Hoffman

For patients whose vasculitis is managed with biologic medications, no reports or evidence-based guidance exists regarding the perioperative management of microvascular flaps. We present a case of a 78-year-old patient with Takayasu’s arteritis (TA) and diabetes mellitus who was taking infliximab and underwent wide local excision of squamous cell carcinoma, craniectomy and reconstruction with a latissimus dorsi flap. TA, an immune-mediated large cell vasculitis characterised by granuloma formation, tends to affect larger vessels and aortic branches. The typical localisation of this condition raises concerns about potentially compromised pedicle and recipient vessels (ie, superficial temporal arteries), which could hinder postoperative flap success. Discontinuation of infliximab 4 weeks before surgery and resumption 6 weeks after led to favourable results. This case addresses the gap in the literature concerning stopping and restarting biologic drugs in the perioperative setting and documents a successful course of a microvascular procedure in a patient with vasculitis.


Oral Oncology ◽  
2021 ◽  
pp. 105225
Author(s):  
Lauren M. North ◽  
Erin Harvey ◽  
Brigitte Vanle ◽  
Aditya Shreenivas ◽  
Monica Shukla ◽  
...  

2014 ◽  
Vol 65 (1) ◽  
pp. 33-42
Author(s):  
José Luis Llorente ◽  
Fernando López ◽  
Vanessa Suárez ◽  
Ángel Fueyo ◽  
Susana Carnero ◽  
...  

Author(s):  
Subbiah Shanmugam ◽  
Syed Afroze Hussain ◽  
Rajiv Michael

<p class="abstract"><strong>Background:</strong> Oral cavity cancer is one of the most common cancers and a leading cause of cancer death in India. Pectoralis major myocutaneous flaps (PMMC) are still widely used for reconstruction of defects in the head and neck, though microvascular free flaps are the ‘gold standard’. This study was aimed to identify the risk factors involved in increasing the post-operative PMMC flap complications.</p><p class="abstract"><strong>Methods:</strong> Patients who underwent surgical resection of primary head and neck cancer with PMMC flap reconstruction were included and their demographic data, pre-operative laboratory values, surgery details and post-operative flap morbidity were collected retrospectively from the master case sheets from January 2013 to December 2019. Factors such as age, gender, stage of disease, pre-operative anemia, hypoprotenemia and radiation therapy, presence of diabetes and size of the flaps were analysed to find their relation in causing flap complications.  </p><p class="abstract"><strong>Results:</strong> Totally 285 patients were included for analysis and 9.82% (n=28) had major flap complications. On analysis we found that pre-operative hypoproteinemia (serum albumin &lt;3.5) (p=0.001) and prior radiation therapy (p=0.02) significantly increased the risk of flap complications. Similarly, patients with larger bipaddled flaps had higher flap complication rates (p=0.0002) and previous radiation treatment further increased the major complication rates in bipaddle flaps.</p><p class="abstract"><strong>Conclusions:</strong> PMMC flaps are still a viable option for head and neck reconstruction especially in patients with multiple comorbidities and where free microvascular flaps are not done routinely. Careful patient selection, pre-operative optimisation and good post-operative care will help to reduce flap complications.</p><p> </p>


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