Simultaneous resection for synchronous colorectal cancer liver metastases: A feasibility clinical trial

2021 ◽  
Author(s):  
Pablo E. Serrano ◽  
Sameer Parpia ◽  
Paul Karanicolas ◽  
Steven Gallinger ◽  
Alice C. Wei ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Clinical Trial ◽  
Liver Metastases ◽  
Colorectal Cancer Liver Metastases ◽  
Simultaneous Resection ◽  
Synchronous Colorectal Cancer

scholarly journals Is simultaneous resection for synchronous colorectal cancer liver metastases safe and effective?

HPB ◽  
2020 ◽  
Vol 22 ◽  
pp. S250-S251
Author(s):  
E. Sobutay ◽  
Ç. Bilgiç ◽  
U. Can ◽  
S. Zenger ◽  
B. Gürbüz ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastases ◽  
Colorectal Cancer Liver Metastases ◽  
Simultaneous Resection ◽  
Synchronous Colorectal Cancer

Simultaneous versus staged resection for synchronous colorectal cancer liver metastases: A population-based cohort study.

2019 ◽  
Vol 37 (4_suppl) ◽  
pp. 665-665 ◽  
Author(s):  
Jessica Bogach ◽  
Julian Wang ◽  
Sameer Parpia ◽  
Marko Simunovic ◽  
Julie I. Hallet ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Overall Survival ◽  
Cohort Study ◽  
Liver Metastases ◽  
Operative Mortality ◽  
Length Of Hospital Stay ◽  
Population Based ◽  
Colorectal Cancer Liver Metastases ◽  
Simultaneous Resection ◽  
Synchronous Colorectal Cancer

665 Background: While considered safe, simultaneous resection of colorectal cancer primary and liver metastases is not performed routinely. We aimed to identify practice patterns, short and long-term outcomes of simultaneous vs. staged resections for synchronous colorectal cancer liver metastases. Methods: We conducted a population-based cohort study of patients undergoing resection for synchronous colorectal cancer liver metastases from 2006-2015 by linking administrative healthcare datasets in Ontario, Canada. Resection of the primary colorectal cancer and liver metastases within six months was considered synchronous disease. Simultaneous (same hospital admission) and staged resections were compared. Outcomes were 90-day post-operative mortality, total length of hospital stay, overall survival and healthcare costs. Survival for the staged group was measured from the last surgical resection to death and estimated using Kaplan Meier. Cost analysis was undertaken from the perspective of a third-party payer and compared using t test. Results: Of 2,738 patients undergoing colorectal and liver resection for colorectal cancer, 1,168 were synchronous, of which, 442 underwent simultaneous resection. The rate of simultaneous resections increased on average by 3% per year (p = 0.02). Median total length of stay was shorter (8 vs. 11 days); 90-day post-operative mortality was higher for simultaneous resections (3.4% vs 1.2%). Median overall survival was worse with simultaneous resection (40 months, 95%CI 35-46 vs. 78 months, 95%CI 59-86), with a 5-year overall survival of 37% (simultaneous) and 55% (staged). Mean overall costs were lower for simultaneous resections ($12,722 CAD vs. $16,455 CAD. Conclusions: Simultaneous resection compared to staged resection for patients with synchronous colorectal cancer liver metastases is associated with higher 90-day postoperative mortality and worse survival. It was associated with shorter length of hospital stay and lower costs for the health cares system. Considering selection bias, randomized studies would be necessary to determine the role of simultaneous resection for synchronous disease colorectal cancer liver metastases.

Management of Synchronous Colorectal Cancer Liver Metastases in Older Patients

2014 ◽  
Vol 186 (2) ◽  
pp. 630-631
Author(s):  
G.M. Vargas ◽  
A.D. Parmar ◽  
K.M. Sheffield ◽  
N.P. Tamirisa ◽  
K.M. Brown ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastases ◽  
Older Patients ◽  
Colorectal Cancer Liver Metastases ◽  
Synchronous Colorectal Cancer

Long‐term results of simultaneous and delayed liver resections of synchronous colorectal cancer liver metastases

2020 ◽  
Vol 90 (6) ◽  
pp. 1119-1124 ◽  
Author(s):  
Maciej Slupski ◽  
Milosz Jasinski ◽  
Stanislaw Pierscinski ◽  
Michal Wicinski
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastases ◽  
Long Term Results ◽  
Colorectal Cancer Liver Metastases ◽  
Liver Resections ◽  
Synchronous Colorectal Cancer

scholarly journals Pilot Clinical Trial of Perioperative Durvalumab and Tremelimumab in the Treatment of Resectable Colorectal Cancer Liver Metastases

2021 ◽  
Author(s):  
Preeti Kanikarla Marie ◽  
Cara Haymaker ◽  
Edwin Roger Parra ◽  
Young Uk Kim ◽  
Rossana Lazcano ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Clinical Trial ◽  
Liver Metastases ◽  
Colorectal Cancer Liver Metastases

scholarly journals Simultaneous or staged resection of synchronous colorectal cancer liver metastases: a 13-year institutional follow-up

HPB ◽  
2021 ◽  
Author(s):  
Anna L. Larsson ◽  
Bergthor Björnsson ◽  
Bärbel Jung ◽  
Olof Hallböök ◽  
Karolina Vernmark ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastases ◽  
Colorectal Cancer Liver Metastases ◽  
Synchronous Colorectal Cancer

scholarly journals Comment on: simultaneous versus delayed resection for initially resectable synchronous colorectal cancer liver metastases

2021 ◽  
Vol 10 (1) ◽  
pp. 131-133
Author(s):  
Gianluca Cassese ◽  
Zineb Cherkaoui ◽  
Francis Navarro ◽  
Patrick Pessaux
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastases ◽  
Colorectal Cancer Liver Metastases ◽  
Synchronous Colorectal Cancer

Simultaneous resection of colorectal cancer with synchronous liver metastases: A survey-based analysis.

2019 ◽  
Vol 37 (4_suppl) ◽  
pp. 662-662
Author(s):  
Christopher Griffiths ◽  
Jessica Bogach ◽  
Marko Simunovic ◽  
Leyo Ruo ◽  
Julie I. Hallet ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastases ◽  
Low Complexity ◽  
Categorical Variables ◽  
Continuous Variables ◽  
Colorectal Cancer Liver Metastases ◽  
Simultaneous Resection ◽  
Clinical Scenarios ◽  
General Surgeons ◽  
Colorectal Resections

662 Background: Decision to proceed with simultaneous or staged resection in synchronous colorectal cancer liver metastases (CRLM) varies and is usually left to the individual surgeon. We examined practice intentions and barriers to performing simultaneous resection. Methods: We developed and pilot-tested a tailored questionnaire. Members of the Society of Surgical Oncology and the College of Physicians and Surgeons of Ontario operating colorectal cancer were surveyed electronically. Four clinical scenarios of synchronous CRLM determined practice intentions for varying degrees of complexity. Perceived barriers were assessed on a 7-point Likert scale. We compared general and hepatobiliary surgeons’ responses with Mann-Whitney U test for continuous variables and Chi-square test for categorical variables. Results: There were 184/1,335 surgeons (14% response rate), including 50 general and 134 hepatobiliary surgeons. Both were supportive of simultaneous resection, though hepatobiliary surgeons were more so; for minor liver and low complexity colorectal resections (Likert ≥5-7: 83% vs. 98% p<0.001), or for complex colorectal resections (57% vs. 73% p=0.042). Both groups were less supportive of simultaneous resection for complex liver with low complexity (Likert ≥5-7: 26% vs. 24% respectively, p=0.858) or high complexity colorectal resections (11% vs. 7.0% respectively, p=0.436). All perceived that simultaneous resection increases post-operative morbidity (63%), but not mortality (69%). Among hepatobiliary surgeons, the most common barriers for simultaneous resections were comorbidities and extrahepatic disease, whereas general surgeons were more concerned about transfer to another facility. Conclusions: While general and hepatobiliary surgeons are supportive of simultaneous resection, especially for less complex liver resections; support is significantly lower among general surgeons. In addition to complexity of procedures and perceived morbidity, the need for transfer of care appears as a barrier to simultaneous resections. The practice intentions and barriers described are important to identify knowledge gaps, guide future trials, and establish disease care pathways.

Simultaneous Versus Delayed Resection for Initially Resectable Synchronous Colorectal Cancer Liver Metastases

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Karim Boudjema ◽  
Clara Locher ◽  
Charles Sabbagh ◽  
Pablo Ortega-Deballon ◽  
Bruno Heyd ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastases ◽  
Colorectal Cancer Liver Metastases ◽  
Synchronous Colorectal Cancer
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