scholarly journals Anterior nasal resistance in obese children with obstructive sleep apnea syndrome

2014 ◽  
Vol 124 (11) ◽  
pp. 2640-2644 ◽  
Author(s):  
Sanghun Sin ◽  
David M. Wootton ◽  
Joseph M. McDonough ◽  
Kiran Nandalike ◽  
Raanan Arens
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Nasal Resistance ◽  
Obese Children ◽  
Obstructive Sleep ◽  
Apnea Syndrome

scholarly journals Computational fluid dynamics endpoints to characterize obstructive sleep apnea syndrome in children

2014 ◽  
Vol 116 (1) ◽  
pp. 104-112 ◽  
Author(s):  
David M. Wootton ◽  
Haiyan Luo ◽  
Steven C. Persak ◽  
Sanghun Sin ◽  
Joseph M. McDonough ◽  
...  
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Nasal Resistance ◽  
Cfd Model ◽  
Obstructive Sleep ◽  
Apnea Syndrome

Computational fluid dynamics (CFD) analysis may quantify the severity of anatomical airway restriction in obstructive sleep apnea syndrome (OSAS) better than anatomical measurements alone. However, optimal CFD model endpoints to characterize or assess OSAS have not been determined. To model upper airway fluid dynamics using CFD and investigate the strength of correlation between various CFD endpoints, anatomical endpoints, and OSAS severity, in obese children with OSAS and controls. CFD models derived from magnetic resonance images were solved at subject-specific peak tidal inspiratory flow; pressure at the choanae was set by nasal resistance. Model endpoints included airway wall minimum pressure (Pmin), flow resistance in the pharynx (Rpharynx), and pressure drop from choanae to a minimum cross section where tonsils and adenoids constrict the pharynx ( dP TAmax). Significance of endpoints was analyzed using paired comparisons ( t-test or Wilcoxon signed rank test) and Spearman correlation. Fifteen subject pairs were analyzed. Rpharynx and dP TAmax were higher in OSAS than control and most significantly correlated to obstructive apnea-hypopnea index (oAHI), r = 0.48 and r = 0.49, respectively ( P < 0.01). Airway minimum cross-sectional correlation to oAHI was weaker ( r = −0.39); Pmin was not significantly correlated. CFD model endpoints based on pressure drops in the pharynx were more closely associated with the presence and severity of OSAS than pressures including nasal resistance, or anatomical endpoints. This study supports the usefulness of CFD to characterize anatomical restriction of the pharynx and as an additional tool to evaluate subjects with OSAS.

Pathogenetic Role of Increased Nasal Resistance in Obese Patients with Obstructive Sleep Apnea Syndrome

2010 ◽  
Vol 24 (1) ◽  
pp. 51-54 ◽  
Author(s):  
Mitsuhiko Tagaya ◽  
Seiichi Nakata ◽  
Fumihiko Yasuma ◽  
Akiko Noda ◽  
Mami Morinaga ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Nasal Resistance ◽  
Obese Patients ◽  
Pathogenetic Role ◽  
Obstructive Sleep ◽  
Apnea Syndrome

The Importance of Nasal Resistance in Obstructive Sleep Apnea Syndrome: A Study with Positional Rhinomanometry

2001 ◽  
Vol 5 (1) ◽  
pp. 3-11 ◽  
Author(s):  
Andrea De Vito ◽  
Stefano Berrettini ◽  
Anna Carabelli ◽  
Stefano Sellari-Franceschini ◽  
Enrica Bonanni ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Nasal Resistance ◽  
Obstructive Sleep ◽  
Apnea Syndrome

scholarly journals MR Image Analytics to Characterize the Upper Airway Structure in Obese Children with Obstructive Sleep Apnea Syndrome

PLoS ONE ◽  
2016 ◽  
Vol 11 (8) ◽  
pp. e0159327 ◽  
Author(s):  
Yubing Tong ◽  
Jayaram K. Udupa ◽  
Sanghun Sin ◽  
Zhengbing Liu ◽  
E. Paul Wileyto ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Upper Airway ◽  
Obese Children ◽  
Mr Image ◽  
Obstructive Sleep ◽  
Apnea Syndrome ◽  
Upper Airway Structure

The Importance of Nasal Resistance in Obstructive Sleep Apnea Syndrome: A Study with Positional Rhinomanometry

2001 ◽  
Vol 05 (01) ◽  
pp. 003-012 ◽  
Author(s):  
Andrea De Vito ◽  
Stefano Berrettini ◽  
Anna Carabelli ◽  
Stefano Sellari-Franceschini ◽  
Enrica Bonanni ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Nasal Resistance ◽  
Obstructive Sleep ◽  
Apnea Syndrome

scholarly journals Childhood Obesity and Respiratory Diseases: Which Link?

Children ◽  
2021 ◽  
Vol 8 (3) ◽  
pp. 177
Author(s):  
Emanuela di di Palmo ◽  
Emanuele Filice ◽  
Alessandra Cavallo ◽  
Carlo Caffarelli ◽  
Giulio Maltoni ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Childhood Obesity ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Respiratory Diseases ◽  
Sleep Apnea Syndrome ◽  
Environment Interaction ◽  
Obese Children ◽  
Obstructive Sleep ◽  
Apnea Syndrome

Prevalence of childhood obesity is progressively increasing, reaching worldwide levels of 5.6% in girls and of 7.8% in boys. Several evidences showed that obesity is a major preventable risk factor and disease modifier of some respiratory conditions such as asthma and Obstructive Sleep Apnea Syndrome (OSAS). Co-occurrence of asthma and obesity may be due to common pathogenetic factors including exposure to air pollutants and tobacco smoking, Western diet, and low Vitamin D levels. Lung growth and dysanapsis phenomenon in asthmatic obese children play a role in impaired respiratory function which appears to be different than in adults. Genes involved in both asthma and obesity have been identified, though a gene-by-environment interaction has not been properly investigated yet. The identification of modifiable environmental factors influencing gene expression through epigenetic mechanisms may change the natural history of both diseases. Another important pediatric respiratory condition associated with obesity is Sleep-Disordered Breathing (SDB), especially Obstructive Sleep Apnea Syndrome (OSAS). OSAS and obesity are linked by a bidirectional causality, where the effects of one affect the other. The factors most involved in the association between OSAS and obesity are oxidative stress, systemic inflammation, and gut microbiota. In OSAS pathogenesis, obesity’s role appears to be mainly due to mechanical factors leading to an increase of respiratory work at night-time. However, a causal link between obesity-related inflammatory state and OSAS pathogenesis still needs to be properly confirmed. To prevent obesity and its complications, family education and precocious lifestyle changes are critical. A healthy diet may lead to an improved quality of life in obese children suffering from respiratory diseases. The present review aimed to investigate the links between obesity, asthma and OSAS, focusing on the available evidence and looking for future research fields.

scholarly journals Cardiometabolic risk profile in non-obese children with obstructive sleep apnea syndrome

2022 ◽  
Author(s):  
Anna Di Sessa ◽  
Giovanni Messina ◽  
Ilaria Bitetti ◽  
Costanza Falanga ◽  
Giovanni Farello ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Cardiometabolic Risk ◽  
Sleep Apnea Syndrome ◽  
Risk Profile ◽  
Obese Children ◽  
Obstructive Sleep ◽  
Apnea Syndrome
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