Reversible drug‐induced Pisa syndrome due to a cholinesterase inhibitor

2021 ◽  
Author(s):  
Arnout Bruggeman ◽  
Lucas Levrau ◽  
Patrick Santens
Keyword(s):  
Cholinesterase Inhibitor ◽  
Drug Induced ◽  
Pisa Syndrome

Relationship Between Pisa Syndrome and Cholinesterase Inhibitor Use for Elderly Adults with Alzheimer's Disease

2014 ◽  
Vol 62 (12) ◽  
pp. 2450-2453 ◽  
Author(s):  
Dominique Huvent-Grelle ◽  
Eric Boulanger ◽  
François Puisieux
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cholinesterase Inhibitor ◽  
Elderly Adults ◽  
Pisa Syndrome

Reversible Pisa syndrome (pleurothotonus) due to the cholinesterase inhibitor galantamine: Case report

2004 ◽  
Vol 19 (10) ◽  
pp. 1243-1244 ◽  
Author(s):  
Giovanni Cossu ◽  
Maurizio Melis ◽  
Giannina Melis ◽  
Elisabetta Maccioni ◽  
Valeria Putzu ◽  
...  
Keyword(s):  
Case Report ◽  
Cholinesterase Inhibitor ◽  
Pisa Syndrome

Relation between cholinesterase inhibitor and Pisa syndrome

The Lancet ◽  
2000 ◽  
Vol 355 (9222) ◽  
pp. 2222 ◽  
Author(s):  
Yong Tae Kwak ◽  
II-Woo Han ◽  
Jongsam Baik ◽  
Min-Seong Koo
Keyword(s):  
Cholinesterase Inhibitor ◽  
Pisa Syndrome

Drug-induced Pisa syndrome under quetiapine

2009 ◽  
Vol 33 (7) ◽  
pp. 1286-1287 ◽  
Author(s):  
Alice Walder ◽  
Waldemar Greil ◽  
Pierre Baumann
Keyword(s):  
Drug Induced ◽  
Pisa Syndrome

Pisa Syndrome Due to a Cholinesterase Inhibitor (Donepezil)

2001 ◽  
Vol 62 (7) ◽  
pp. 573-574 ◽  
Author(s):  
Tsuyoshi Miyaoka ◽  
Haruo Seno ◽  
Chikako Yamamori ◽  
Takuji Inagaki ◽  
Motoi Itoga ◽  
...  
Keyword(s):  
Cholinesterase Inhibitor ◽  
Pisa Syndrome

Drug-Induced Pisa Syndrome (Pleurothotonus)

CNS Drugs ◽  
2002 ◽  
Vol 16 (3) ◽  
pp. 165-174 ◽  
Author(s):  
Toshihito Suzuki ◽  
Hisashi Matsuzaka
Keyword(s):  
Drug Induced ◽  
Pisa Syndrome

Drug-induced Pisa syndrome associated with aripiprazole during clozapine treatment

2010 ◽  
Vol 34 (4) ◽  
pp. 707-708 ◽  
Author(s):  
Hsing-Kang Chen ◽  
Bo-Jian Wu ◽  
Ching-Han Shao
Keyword(s):  
Drug Induced ◽  
Clozapine Treatment ◽  
Pisa Syndrome

Early Development of Drug-Induced Hepatic Necrosis

1971 ◽  
Vol 29 ◽  
pp. 576-577
Author(s):  
F. G. Zaki ◽  
E. Detzi ◽  
C. H. Keysser
Keyword(s):  
Early Development ◽  
Hepatic Necrosis ◽  
Screening Tests ◽  
Dense Matrix ◽  
Sprague Dawley ◽  
Electron Microscopic ◽  
Drug Induced ◽  
Hepatocellular Damage ◽  
Sprague Dawley Rats ◽  
Microscopic Studies

This study represents the first in a series of investigations carried out to elucidate the mechanism(s) of early hepatocellular damage induced by drugs and other related compounds. During screening tests of CNS-active compounds in rats, it has been found that daily oral administration of one of these compounds at a dose level of 40 mg. per kg. of body weight induced diffuse massive hepatic necrosis within 7 weeks in Charles River Sprague Dawley rats of both sexes. Partial hepatectomy enhanced the development of this peculiar type of necrosis (3 weeks instead of 7) while treatment with phenobarbital prior to the administration of the drug delayed the appearance of necrosis but did not reduce its severity.Electron microscopic studies revealed that early development of this liver injury (2 days after the administration of the drug) appeared in the form of small dark osmiophilic vesicles located around the bile canaliculi of all hepatocytes (Fig. 1). These structures differed from the regular microbodies or the pericanalicular multivesicular bodies. They first appeared regularly rounded with electron dense matrix bound with a single membrane. After one week on the drug, these vesicles appeared vacuolated and resembled autophagosomes which soon developed whorls of concentric lamellae or cisterns characteristic of lysosomes (Fig. 2). These lysosomes were found, later on, scattered all over the hepatocytes.

Effect of piperacillin on morphology and viability of gram-negative bacteria

1984 ◽  
Vol 42 ◽  
pp. 218-219
Author(s):  
R. H. Liss
Keyword(s):  
Inhibitory Concentration ◽  
Cytoplasmic Membrane ◽  
Drug Binding ◽  
Gram Negative Bacteria ◽  
Bacterial Cells ◽  
Drug Induced ◽  
Penicillin Binding Proteins ◽  
Lactam Antibiotic ◽  
Drug Free ◽  
Tube Dilution

Piperacillip (PIP) is b-[D(-)-α-(4-ethy1-2,3-dioxo-l-piperzinylcar-bonylamino)-α-phenylacetamido]-penicillanate. The broad spectrum semisynthetic β-lactam antibiotic is believed to effect bactericidal activity through its affinity for penicillin-binding proteins (PBPs), enzymes on the bacterial cytoplasmic membrane that control elongation and septation during cell growth and division. The purpose of this study was to correlate penetration and binding of 14C-PIP in bacterial cells with drug-induced lethal changes assessed by microscopic, microbiologic and biochemical methods.The bacteria used were clinical isolates of Escherichia coli and Pseudomonas aeruginosa (Figure 1). Sensitivity to the drug was determined by serial tube dilution in Trypticase Soy Broth (BBL) at an inoculum of 104 organisms/ml; the minimum inhibitory concentration of piperacillin for both bacteria was 1 μg/ml. To assess drug binding to PBPs, the bacteria were incubated with 14C-PIP (5 μg/0.09 μCi/ml); controls, in drug-free medium.

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