The discovery of α‐synuclein in Lewy pathology of Parkinson's disease: The inspiration of a revolution

2021 ◽  
Author(s):  
Naomi P. Visanji ◽  
Gabor G. Kovacs ◽  
Anthony E. Lang
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Lewy Pathology

A comparison between rectal and colonic biopsies to detect Lewy pathology in Parkinson's disease

2012 ◽  
Vol 45 (1) ◽  
pp. 305-309 ◽  
Author(s):  
Hélène Pouclet ◽  
Thibaud Lebouvier ◽  
Emmanuel Coron ◽  
Stanislas Bruley des Varannes ◽  
Tiphaine Rouaud ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Lewy Pathology ◽  
Colonic Biopsies

Loss of fragile X mental retardation protein precedes Lewy pathology in Parkinson’s disease

2019 ◽  
Vol 139 (2) ◽  
pp. 319-345 ◽  
Author(s):  
Yi Tan ◽  
Carmelo Sgobio ◽  
Thomas Arzberger ◽  
Felix Machleid ◽  
Qilin Tang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mental Retardation ◽  
Fragile X ◽  
Lewy Pathology ◽  
Fragile X Mental Retardation ◽  
Mental Retardation Protein

A comparison between colonic submucosa and mucosa to detect Lewy pathology in Parkinson’s disease

2012 ◽  
Vol 24 (4) ◽  
pp. e202-e205 ◽  
Author(s):  
H. Pouclet ◽  
T. Lebouvier ◽  
E. Coron ◽  
S. B. Des Varannes ◽  
M. Neunlist ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Lewy Pathology

Lewy pathology in gastric and duodenal biopsies in Parkinson's Disease

2012 ◽  
Vol 27 (6) ◽  
pp. 708-708 ◽  
Author(s):  
Hélène Pouclet ◽  
Thibaud Lebouvier ◽  
Emmanuel Coron ◽  
Michel Neunlist ◽  
Pascal Derkinderen
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Lewy Pathology ◽  
Duodenal Biopsies

scholarly journals Variants in the Niemann-Pick type C gene NPC1 are not associated with Parkinson’s disease

2020 ◽  
Author(s):  
Bouchra Ouled Amar Bencheikh ◽  
Konstantin Senkevich ◽  
Uladzislau Rudakou ◽  
Eric Yu ◽  
Kheireddin Mufti ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rare Variants ◽  
Transmembrane Protein ◽  
Alpha Synuclein ◽  
Common Variants ◽  
Optimal Sequence ◽  
Lewy Pathology ◽  
Type C ◽  
Niemann Pick

AbstractBiallelic variants in NPC1, a lysosomal gene coding for a transmembrane protein involved in cholesterol trafficking, may cause Niemann-Pick disease type C (NPC). A few cases of NPC1 mutation carriers have been reported with a Parkinson’s disease (PD) presentation. In addition, pathological studies demonstrated phosphorylated alpha-synuclein and Lewy pathology in brains of NPC patients. Therefore, we aimed to examine whether NPC1 genetic variants may be associated with PD. Full sequencing of NPC1 was performed in 2,657 PD patients and 3,647 controls from three cohorts, using targeted sequencing with molecular inversion probes. A total of 9 common variants and 126 rare variants were identified across the three cohorts. To examine association with PD, regression models adjusted for age, sex and origin were performed for common variants, and optimal sequence Kernel association test (SKAT-O) was performed for rare variants. After correction for multiple comparisons, common and rare NPC1 variants were not associated with PD. Our results do not support a link between heterozygous variants in NPC1 and PD.

scholarly journals Luminescent conjugated oligothiophenes distinguish between α-synuclein assemblies of Parkinson’s disease and multiple system atrophy

2019 ◽  
Vol 7 (1) ◽  
Author(s):  
Therése Klingstedt ◽  
Bernardino Ghetti ◽  
Janice L. Holton ◽  
Helen Ling ◽  
K. Peter R. Nilsson ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Multiple System Atrophy ◽  
Lewy Bodies ◽  
Fluorescence Lifetime Imaging ◽  
Cytoplasmic Inclusions ◽  
Glial Cytoplasmic Inclusions ◽  
Lewy Pathology ◽  
Lifetime Imaging ◽  
The Difference

AbstractSynucleinopathies [Parkinson’s disease with or without dementia, dementia with Lewy bodies and multiple system atrophy] are neurodegenerative diseases that are defined by the presence of filamentous α-synuclein inclusions. We investigated the ability of luminescent conjugated oligothiophenes to stain the inclusions of Parkinson’s disease and multiple system atrophy. They stained the Lewy pathology of Parkinson’s disease and the glial cytoplasmic inclusions of multiple system atrophy. Spectral analysis of HS-68-stained inclusions showed a red shift in multiple system atrophy, but the difference with Parkinson’s disease was not significant. However, when inclusions were double-labelled for HS-68 and an antibody specific for α-synuclein phosphorylated at S129, they could be distinguished based on colour shifts with blue designated for Parkinson’s disease and red for multiple system atrophy. The inclusions of Parkinson’s disease and multiple system atrophy could also be distinguished using fluorescence lifetime imaging. These findings are consistent with the presence of distinct conformers of assembled α-synuclein in Parkinson’s disease and multiple system atrophy.

scholarly journals Detection of Phosphorylated Alpha-Synuclein in the Muscularis Propria of the Gastrointestinal Tract Is a Sensitive Predictor for Parkinson’s Disease

2020 ◽  
Vol 2020 ◽  
pp. 1-8 ◽  
Author(s):  
Goichi Beck ◽  
Yumiko Hori ◽  
Yoshito Hayashi ◽  
Eiichi Morii ◽  
Tetsuo Takehara ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Nervous System ◽  
Myenteric Plexus ◽  
Muscularis Propria ◽  
Alpha Synuclein ◽  
Nerve Fibers ◽  
Motor Symptoms ◽  
Submucosal Plexus ◽  
Lewy Pathology

Background. Parkinson’s disease (PD) is a neurodegenerative disorder characterized by motor and nonmotor impairments, including constipation. Lewy bodies and neurites, the pathological hallmarks of PD, are found in the enteric nervous system (ENS) as well as the central nervous system. Constipation is a well-documented premotor symptom in PD, and recent reports have demonstrated Lewy pathology in gastrointestinal (GI) tissues of PD patients prior to the onset of motor symptoms. Objective. In the present study, we assessed Lewy pathology in the GI tracts of seven PD patients who had undergone a gastrectomy, gastric polypectomy, or colonic polypectomy prior to the onset of motor symptoms in order to assess whether the presence of pathological αSyn in the ENS could be a predictor for PD. Methods. GI tissue samples were collected from control patients and patients with premotor PD. Immunohistochemistry was performed using primary antibodies against α-synuclein (αSyn) and phosphorylated αSyn (pαSyn), after which Lewy pathology in each sample was assessed. Results. In all control and premotor PD patients, accumulation of αSyn was observed in the myenteric plexus in both the stomach and colon. In 82% (18/22) of control patients, mild-to-moderate accumulation of αSyn was observed in the submucosal plexus. However, there was no deposition of pαSyn in the ENS of control patients. In patients with premotor PD, abundant accumulation of αSyn was observed in the myenteric plexus, similar to control patients. On the other hand, pαSyn-positive aggregates were also observed in the nerve fibers in the muscularis propria in all examined patients with premotor PD (100%, 3/3), while the deposition of pαSyn in the submucosal plexus was only observed in one patient (14%, 1/7). Conclusion. Our results suggest that the detection of pαSyn, but not αSyn, especially in the muscularis propria of GI tracts, could be a sensitive prodromal biomarker for PD.

Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson’s disease

2010 ◽  
Vol 119 (6) ◽  
pp. 703-713 ◽  
Author(s):  
Kelly Del Tredici ◽  
Christopher H. Hawkes ◽  
Estifanos Ghebremedhin ◽  
Heiko Braak
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Submandibular Gland ◽  
Lewy Body ◽  
Lewy Body Disease ◽  
Lewy Pathology ◽  
Incidental Lewy Body Disease ◽  
Sporadic Parkinson’S Disease

scholarly journals Hippocampal CA2 Lewy pathology is associated with cholinergic degeneration in Parkinson’s disease with cognitive decline

2019 ◽  
Vol 7 (1) ◽  
Author(s):  
Alan King Lun Liu ◽  
Tsz Wing Chau ◽  
Ernest Junwei Lim ◽  
Idil Ahmed ◽  
Raymond Chuen-Chung Chang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Decline ◽  
Lewy Pathology ◽  
Cholinergic Degeneration
Sign in / Sign up

Export Citation Format

Share Document