Dyspnea as first sign of autonomic failure in postmortem confirmed multiple system atrophy

2010 ◽  
Vol 25 (12) ◽  
pp. 1997-1998 ◽  
Author(s):  
Wassilios G Meissner ◽  
Anne Vital ◽  
Imad Ghorayeb ◽  
Dominique Guehl ◽  
François Tison
Keyword(s):  
Multiple System Atrophy ◽  
Autonomic Failure

Multiple system atrophy-autonomic failure: A case with early laryngeal stridor and without orthostatic hypotension

1991 ◽  
Vol 12 (2) ◽  
pp. 225-228
Author(s):  
D. Bettucci ◽  
M. Gianelli ◽  
G. Ruata ◽  
R. Cantello ◽  
R. Mutani ◽  
...  
Keyword(s):  
Multiple System Atrophy ◽  
Orthostatic Hypotension ◽  
Autonomic Failure ◽  
Laryngeal Stridor

Calf venous compliance in multiple system atrophy

2007 ◽  
Vol 293 (1) ◽  
pp. H260-H265 ◽  
Author(s):  
A. Lipp ◽  
P. Sandroni ◽  
J. Eric Ahlskog ◽  
D. M. Maraganore ◽  
C. W. Shults ◽  
...  
Keyword(s):  
Multiple System Atrophy ◽  
Rating Scale ◽  
Matched Control ◽  
Autonomic Failure ◽  
Lower Leg ◽  
Severity Scale ◽  
Adrenergic Stimulation ◽  
Venous Compliance ◽  
Capillary Filtration ◽  
Venous Filling

In multiple system atrophy (MSA), increased venous compliance with excessive venous pooling is assumed to be a major contributor to orthostatic hypotension (OH); however, venous compliance has never been assessed in MSA patients. We evaluated the severity and distribution of adrenergic, cardiovagal, and sudomotor failure in 11 patients with probable MSA, 14 age- and sex-matched control subjects, and 8 patients with Parkinson's disease (PD) but not OH. Calf venous compliance, venous filling, and capillary filtration were measured using calf plethysmography. The response to the directly acting α-adrenergic stimulation (10 mg midodrine) on calf venous compliance was additionally evaluated. Contrary to our hypothesis, pressure-volume curves in the legs of MSA patients were flatter than in PD patients ( P < 0.05) or controls ( P < 0.001); this indicated reduced calf venous compliance in MSA. The MSA group had reduced venous filling compared with control ( P < 0.001) or PD subjects ( P < 0.001) but had a normal capillary filtration rate ( P = 0.73). Direct α-adrenergic stimulation resulted in a slight but significant reduction of calf venous compliance in controls ( P = 0.001) and PD subjects ( P < 0.001) but not in the MSA group. The compliance change in MSA significantly regressed with autonomic failure (composite autonomic severity scale, r2 = 0.56) but not with parkinsonism (Unified MSA Rating Scale, r2 = 0.12). Our data indicate that MSA patients with chronic OH have reduced, rather than increased, venous compliance in the lower leg. We postulate that chronic venous distension that is associated with OH results in structural remodeling of veins, leading to reduced compliance, a change which may protect patients against orthostatic stress.

Differences in skin sympathetic involvements between two chronic autonomic disorders: Multiple system atrophy and pure autonomic failure

2009 ◽  
Vol 15 (5) ◽  
pp. 347-350 ◽  
Author(s):  
Masato Asahina ◽  
Yuichi Akaogi ◽  
Yoshitaka Yamanaka ◽  
Yu Koyama ◽  
Takamichi Hattori
Keyword(s):  
Multiple System Atrophy ◽  
Autonomic Failure ◽  
Pure Autonomic Failure ◽  
Autonomic Disorders

Proposal of modified autonomic failure criteria for the diagnosis of multiple system atrophy

2017 ◽  
Vol 381 ◽  
pp. 897-898
Author(s):  
Y. Yamanaka ◽  
M. Beppu ◽  
N. Araki ◽  
A. Katagiri ◽  
Y. Fujinuma ◽  
...  
Keyword(s):  
Multiple System Atrophy ◽  
Autonomic Failure ◽  
Failure Criteria

The cardiovascular effects of metoclopramide in multiple system atrophy and pure autonomic failure

2001 ◽  
Vol 11 (3) ◽  
pp. 163-168 ◽  
Author(s):  
Fabiola Magnifico ◽  
Giulia Pierangeli ◽  
Giorgio Barletta ◽  
Carmen Candela ◽  
Giuseppe Bonavina ◽  
...  
Keyword(s):  
Multiple System Atrophy ◽  
Autonomic Failure ◽  
Cardiovascular Effects ◽  
Pure Autonomic Failure
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