Multiple system atrophy-autonomic failure: A case with early laryngeal stridor and without orthostatic hypotension

1991 ◽  
Vol 12 (2) ◽  
pp. 225-228
Author(s):  
D. Bettucci ◽  
M. Gianelli ◽  
G. Ruata ◽  
R. Cantello ◽  
R. Mutani ◽  
...  
Keyword(s):  
Multiple System Atrophy ◽  
Orthostatic Hypotension ◽  
Autonomic Failure ◽  
Laryngeal Stridor

Symptoms associated with orthostatic hypotension in pure autonomic failure and multiple system atrophy

1999 ◽  
Vol 246 (10) ◽  
pp. 893-898 ◽  
Author(s):  
C. J. Mathias ◽  
Rajeev Mallipeddi ◽  
Katharine Bleasdale-Barr
Keyword(s):  
Multiple System Atrophy ◽  
Orthostatic Hypotension ◽  
Autonomic Failure ◽  
Pure Autonomic Failure

Abstract P381: Understanding the Symptoms of Neurogenic Orthostatic Hypotension: Results From a Survey of Patients and Caregivers

Hypertension ◽  
2017 ◽  
Vol 70 (suppl_1) ◽  
Author(s):  
Lawrence A Hewitt ◽  
Charles H Adler ◽  
Daniel O Claassen ◽  
Christopher H Gibbons ◽  
Satish R Raj
Keyword(s):  
Multiple System Atrophy ◽  
Parkinson Disease ◽  
Orthostatic Hypotension ◽  
Autonomic Failure ◽  
Alpha Synuclein ◽  
Pure Autonomic Failure ◽  
Motor Symptoms ◽  
Neurogenic Orthostatic Hypotension ◽  
The Past ◽  
Increased Risk

Objective: To understand the burden and impact of symptoms of neurogenic orthostatic hypotension (nOH) on patients Background: nOH and its symptoms such as dizziness/lightheadedness are common in patients with Parkinson disease (PD) and other forms of autonomic dysfunction. Methods: An author-designed, US-based survey was conducted by Harris Poll. Eligible participants were aged ≥18 years with PD, multiple system atrophy (MSA), or pure autonomic failure and ≥1 of the following: orthostatic hypotension, nOH, low BP, OH/nOH symptoms, or were caregivers of eligible patients. Results: Most patients (90%) had a diagnosis of PD, and most caregivers (88%) cared for a patient with PD (Table 1) . Patients (34%) and caregivers (49%) reported experiencing nOH symptoms before PD or MSA motor symptoms and >40% indicated that nOH symptoms were more troublesome than motor manifestations of PD or MSA. Less than a quarter (22%) of respondents suggested symptoms were most severe in the morning; more (30%) reported a consistent severity throughout the day. Patients (40%) and caregivers (63%) reported trouble managing symptoms during the day. In the past 12 months, a fall due to nOH symptoms was reported by 57% of patients and 80% of caregivers. Conclusions: These findings suggest that nOH symptoms may predate the onset of motor symptoms in neurodegenerative conditions linked to alpha-synuclein pathology. Many respondents report nOH symptoms are the same severity through the day. Patients with nOH may have trouble managing symptoms and note an increased risk for falls.

Case 44: Multiple System Atrophy

2019 ◽  
pp. 245-248
Author(s):  
Peter Novak
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Multiple System Atrophy ◽  
Orthostatic Hypotension ◽  
Autonomic Failure ◽  
Cerebral Hypoperfusion ◽  
Autonomic Testing ◽  
The Central Nervous System

Multiple system atrophy (MSA) is associated with severe autonomic failure of the central nervous system. Autonomic testing showed a typical MSA pattern including severe sympathetic adrenergic and parasympathetic failure with orthostatic hypotension and cerebral hypoperfusion.

Dyspnea as first sign of autonomic failure in postmortem confirmed multiple system atrophy

2010 ◽  
Vol 25 (12) ◽  
pp. 1997-1998 ◽  
Author(s):  
Wassilios G Meissner ◽  
Anne Vital ◽  
Imad Ghorayeb ◽  
Dominique Guehl ◽  
François Tison
Keyword(s):  
Multiple System Atrophy ◽  
Autonomic Failure
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