Platelet gel does not improve peripheral nerve regeneration: An electrophysiological, stereological, and electron microscopic study

Microsurgery ◽  
2008 ◽  
Vol 29 (2) ◽  
pp. 144-153 ◽  
Author(s):  
Ahmet Piskin ◽  
Suleyman Kaplan ◽  
Abit Aktaş ◽  
Mustafa Ayyildiz ◽  
Stefania Raimondo ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Microscopic Study ◽  
Electron Microscopic Study ◽  
Peripheral Nerve Regeneration ◽  
Electron Microscopic ◽  
Platelet Gel

A review of the central response to peripheral nerve injury and its significance in nerve regeneration

1972 ◽  
Vol 37 (2) ◽  
pp. 195-203 ◽  
Author(s):  
Chardes A. Engh ◽  
Brian H. Schofield
Keyword(s):  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Peripheral Nerve Regeneration ◽  
Peripheral Nerve Injuries ◽  
Electron Microscopic ◽  
Content Type ◽  
Peripheral Neurons ◽  
Central Response ◽  
Regenerative Activity ◽  
Peripheral Axon

✓ Chromatolysis is a morphological term used to describe a sequence of light microscopic changes occurring in the cell bodies (perikarya) of peripheral neurons after injury to their peripherally directed axons. The authors have attempted to interpret the significance of chromatolysis to peripheral nerve regeneration and to describe how central regenerative activity may be affected by peripheral regeneration. Electron microscopic perikaryal changes following peripheral nerve injuries initially appear to be manifestations of a nonspecific cellular insult with possible loss of trophic influence, and secondarily a reflection of neuronal readjustment to a decrease in peripheral axon demands. Sectioning of peripheral axons results initially in decreased perikaryal axonal cytoplasm synthesis. Return of normal and sometimes greater than normal perikaryal cytoplasm production and a return of normal perikaryal morphology are characteristics of the maturation phase of peripheral nerve regeneration and occur only if peripheral axon regrowth is successful.

Sign in / Sign up

Export Citation Format

Share Document