Diabetes mellitus after bone marrow transplantation during childhood

2002 ◽  
Vol 40 (2) ◽  
pp. 128-129 ◽  
Author(s):  
C. Traggiai ◽  
R. Stanhope ◽  
S. Nussey ◽  
A.D. Leiper
Keyword(s):  
Diabetes Mellitus ◽  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Marrow Transplantation

Bone Marrow Transplantation Induces Normoglycemia in a Type 2 Diabetes Mellitus Murine Model

2009 ◽  
Vol 41 (6) ◽  
pp. 2282-2285 ◽  
Author(s):  
M. Flaquer ◽  
M. Franquesa ◽  
J. Barquinero ◽  
N. Lloberas ◽  
C. Gutiérrez ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Bone Marrow ◽  
Type 2 Diabetes Mellitus ◽  
Bone Marrow Transplantation ◽  
Murine Model ◽  
Marrow Transplantation

scholarly journals Bone marrow transplantation as a strategy for treatment of non-insulin-dependent diabetes mellitus in KK-Ay mice.

1992 ◽  
Vol 176 (4) ◽  
pp. 1233-1238 ◽  
Author(s):  
S Than ◽  
H Ishida ◽  
M Inaba ◽  
Y Fukuba ◽  
Y Seino ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Marrow Transplantation ◽  
Bone Marrow Cells ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Insulin Dependent ◽  
Ay Mice

The effects of allogeneic bone marrow transplantation (BMT) on non-insulin-dependent diabetes mellitus (NIDDM) were examined using KK-Ay mice. KK-Ay mice reconstituted with KK-Ay bone marrow cells showed glycosuria, hyperinsulinemia, and hyperlipidemia. However, KK-Ay mice (H-2b) that had been lethally irradiated (9.0 Gy) and then reconstituted with T cell-depleted bone marrow cells from normal BALB/c mice (H-2d) showed negative urine sugar with decreases in serum insulin and lipid levels 4 mo after BMT. Morphological recovery of islets and glomeruli was also noted after allogeneic BMT. These findings suggest that BMT can be used to treat not only a certain type of NIDDM but also its complications such as hyperlipidemia and diabetic nephropathy.

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