Chromosomal aberrations, Yq microdeletion, and sperm DNA fragmentation in infertile men opting for assisted reproduction

2012 ◽  
Vol 79 (9) ◽  
pp. 637-650 ◽  
Author(s):  
Monis B. Shamsi ◽  
Rajeev Kumar ◽  
Neena Malhotra ◽  
Nita Singh ◽  
Suneeta Mittal ◽  
...  
Keyword(s):  
Dna Fragmentation ◽  
Assisted Reproduction ◽  
Chromosomal Aberrations ◽  
Sperm Dna Fragmentation ◽  
Infertile Men ◽  
Sperm Dna

Sperm DNA fragmentation in infertile men with genitourinary infection by Chlamydia trachomatis and Mycoplasma

2008 ◽  
Vol 90 (2) ◽  
pp. 328-334 ◽  
Author(s):  
Guadalupe Gallegos ◽  
Benito Ramos ◽  
Rebeca Santiso ◽  
Vicente Goyanes ◽  
Jaime Gosálvez ◽  
...  
Keyword(s):  
Chlamydia Trachomatis ◽  
Dna Fragmentation ◽  
Sperm Dna Fragmentation ◽  
Infertile Men ◽  
Sperm Dna ◽  
Genitourinary Infection

What is the role of varicocelectomy in infertile men with clinical varicoceles and elevated sperm DNA fragmentation?

2021 ◽  
Vol 116 (3) ◽  
pp. 657-658
Author(s):  
Shirley L. Wang ◽  
Bronwyn S. Bedrick ◽  
Taylor P. Kohn
Keyword(s):  
Dna Fragmentation ◽  
Sperm Dna Fragmentation ◽  
Infertile Men ◽  
Sperm Dna

P–004 Effect of varicocelectomy on sperm DNA fragmentation rates in infertile men with clinical varicocele: a systematic review and meta-analysis

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
F Tenori. Lir. Neto ◽  
M Roque ◽  
S Esteves
Keyword(s):  
Systematic Review ◽  
Surgical Technique ◽  
Dna Fragmentation ◽  
Subgroup Analysis ◽  
Meta Analysis ◽  
Sperm Dna Fragmentation ◽  
Inclusion Criteria ◽  
Infertile Men ◽  
Sperm Dna ◽  
The Impact

Abstract Study question Does varicocelectomy improve sperm DNA quality in men with infertility and clinically detected varicoceles? Summary answer Varicocelectomy reduces sperm DNA fragmentation (SDF) rates in infertile men with clinical varicocele. What is known already Varicocele has been linked to male infertility through various non-mutually exclusive mechanisms, including an increase in reactive oxygen species (ROS) production that may lead to sperm DNA damage. Damage to sperm DNA may result in longer time-to-pregnancy, unexplained infertility, recurrent pregnancy loss, and failed intrauterine insemination or in vitro fertilization/intracytoplasmic sperm injection. Therefore, interventions aimed at decreasing SDF rates, including varicocele repair, have been explored to improve fertility and pregnancy outcomes potentially, either by natural conception or using medically assisted reproduction. Study design, size, duration Systematic review and meta-analysis Participants/materials, setting, methods We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Our systematic search included PubMed/Medline, EMBASE, Scielo, and Google Scholar to identify all relevant studies written in English and published from inception until October 2020. Inclusion criteria were studies comparing SDF rates before and after varicocelectomy in infertile men with clinical varicocele. Articles were included if the following SDF assays were utilized: SCSA, TUNEL, SCD test, or alkaline Comet. Main results and the role of chance Thirteen studies fulfilled the inclusion criteria and were selected for the analysis. The estimated weighted mean difference of SDF rates after varicocelectomy was –6.58% (13 studies, 95% CI –8.33%, –4.84%; I2=90% p < 0.0001). Subgroup analysis revealed a significant decrease in SDF rates using SCSA (eight studies, WMD –6.80%, 95% CI –9.31%, –4.28%; I2=89%, p < 0.0001), and TUNEL (three studies, WMD –4.86%, 95% CI –7.38%, –2.34%; I2=89%, p < 0.0001). The test for subgroup difference revealed that pooled results were conservative using the above SDF assays. Comet and SCD tests were used in only one study each; thus, a meta-analysis was not applicable. The studies were further categorized by the surgical technique (microsurgical versus non-microsurgical). This subgroup analysis showed a significant decrease in SDF rates using microsurgical technique (10 studies, WMD –6.70%, 95% CI –9.04%, –4.37%; I2=91%, p < 0.0001). After varicocelectomy, SDF rates were also decreased when non-microsurgical approaches were used, albeit the effect was not statistically significant (2 studies, WMD –6.84%, 95% CI –10.05%, 1.38%; I2=86%) (Figure 3). The heterogeneity was not materially affected by performing analyses by the above subgroups, suggesting that the SDF assay and surgical technique do not explain the inconsistency in the treatment effect across primary studies. Limitations, reasons for caution There were no randomized controlled trials comparing varicocelectomy to placebo for alleviating SDF levels. Heterogeneity was high, which may be explained by the low number of included studies. Pregnancy data are not available in most studies, thus the impact of reduced SDF after varicocelectomy on pregnancy rates unclear. Wider implications of the findings: Our study indicates a positive association between varicocelectomy and reduced postoperative SDF rates in men with clinical varicocele and infertility, independentetly of the assays used to measure SDF. These findings may help counsel and manage infertile men with varicocele and high SDF levels. Trial registration number Not applicable

Evaluation of sperm DNA fragmentation index, Zinc concentration and seminal parameters from infertile men with varicocele

Andrologia ◽  
2018 ◽  
Vol 51 (2) ◽  
pp. e13184 ◽  
Author(s):  
Thi Trang Nguyen ◽  
Tien Sang Trieu ◽  
Thi Oanh Tran ◽  
Thi Lan Anh Luong
Keyword(s):  
Dna Fragmentation ◽  
Zinc Concentration ◽  
Sperm Dna Fragmentation ◽  
Infertile Men ◽  
Seminal Parameters ◽  
Fragmentation Index ◽  
Sperm Dna ◽  
Sperm Dna Fragmentation Index ◽  
Dna Fragmentation Index

scholarly journals Oxidation–reduction potential and sperm DNA fragmentation, and their associations with sperm morphological anomalies amongst fertile and infertile men

2018 ◽  
Vol 16 (1) ◽  
pp. 87-95 ◽  
Author(s):  
Ahmad Majzoub ◽  
Mohamad Arafa ◽  
Mohamed Mahdi ◽  
Ashok Agarwal ◽  
Sami Al Said ◽  
...  
Keyword(s):  
Dna Fragmentation ◽  
Reduction Potential ◽  
Sperm Dna Fragmentation ◽  
Infertile Men ◽  
Oxidation Reduction ◽  
Oxidation Reduction Potential ◽  
Sperm Dna ◽  
Morphological Anomalies

scholarly journals Diagnostic value of sperm DNA fragmentation and sperm high-magnification for predicting outcome of assisted reproduction treatment

2013 ◽  
Vol 15 (6) ◽  
pp. 790-794 ◽  
Author(s):  
Gemma López ◽  
Rafael Lafuente ◽  
Miguel A Checa ◽  
Ramón Carreras ◽  
Mario Brassesco
Keyword(s):  
Dna Fragmentation ◽  
Assisted Reproduction ◽  
Diagnostic Value ◽  
Sperm Dna Fragmentation ◽  
High Magnification ◽  
Sperm Dna ◽  
Predicting Outcome ◽  
Assisted Reproduction Treatment

High-risk human papillomavirus in semen is associated with poor sperm progressive motility and a high sperm DNA fragmentation index in infertile men

2018 ◽  
Vol 34 (2) ◽  
pp. 209-217 ◽  
Author(s):  
Luca Boeri ◽  
Paolo Capogrosso ◽  
Eugenio Ventimiglia ◽  
Filippo Pederzoli ◽  
Walter Cazzaniga ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
High Risk ◽  
Dna Fragmentation ◽  
Sperm Dna Fragmentation ◽  
Progressive Motility ◽  
Infertile Men ◽  
Fragmentation Index ◽  
Sperm Dna ◽  
Sperm Dna Fragmentation Index ◽  
Dna Fragmentation Index

Association between sperm DNA fragmentation and aneuploidy rate in assisted reproduction patients

2009 ◽  
Vol 92 (3) ◽  
pp. S140
Author(s):  
T.M. Vulcani-Freitas ◽  
P.C.R. Motta ◽  
J.F. Cuzzi ◽  
T. Serzedello ◽  
P.A. Hassun-Filho
Keyword(s):  
Dna Fragmentation ◽  
Assisted Reproduction ◽  
Sperm Dna Fragmentation ◽  
Aneuploidy Rate ◽  
Sperm Dna
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