Phrenic nerve conduction studies in spinal cord injury: Applications for diaphragmatic pacing

2008 ◽  
Vol 38 (6) ◽  
pp. 1546-1552 ◽  
Author(s):  
Amer Alshekhlee ◽  
Raymond P. Onders ◽  
Tanvir U. Syed ◽  
Maryjo Elmo ◽  
Bashar Katirji
1968 ◽  
Vol 61 (4) ◽  
pp. 420-423
Author(s):  
L H COWLEY ◽  
P W DAVIS ◽  
H P DUMAS ◽  
J H HASSON ◽  
C C HUDSON ◽  
...  

2017 ◽  
Vol 79 (2) ◽  
pp. 180-182 ◽  
Author(s):  
Kulvir S. Nandra ◽  
Martin Harari ◽  
Thea P. Price ◽  
Patrick J. Greaney ◽  
Michael S. Weinstein

2000 ◽  
Vol 89 (4) ◽  
pp. 1528-1536 ◽  
Author(s):  
Shi-Yi Zhou ◽  
Harry G. Goshgarian

The present study investigates the role of serotonin in respiratory recovery after spinal cord injury. Experiments were conducted on C2 spinal cord hemisected, anesthetized, vagotomized, paralyzed, and artificially ventilated rats in which end-tidal CO2 was monitored and maintained. Before drug administration, the phrenic nerve ipsilateral to hemisection showed no respiratory-related activity due to the disruption of the descending bulbospinal respiratory pathways by spinal cord hemisection. 5-Hydroxytryptophan (5-HTP), a serotonin precursor, was administrated intravenously. 5-HTP induced time- and dose-dependent increases in respiratory recovery in the phrenic nerve ipsilateral to hemisection. Although the 5-HTP-induced recovery was initially accompanied by an increase in activity in the contralateral phrenic nerve, suggesting an increase in descending respiratory drive, the recovery persisted well after activity in the contralateral nerve returned to predrug levels. 5-HTP-induced effects were reversed by a serotonin receptor antagonist, methysergide. Because experiments were conducted on animals subjected to C2 spinal cord hemisection, the recovery was most likely mediated by the activation of a latent respiratory pathway spared by the spinal cord injury. The results suggest that serotonin is an important neuromodulator in the unmasking of the latent respiratory pathway after spinal cord injury. In addition, the results also suggest that the maintenance of 5-HTP-induced respiratory recovery may not require a continuous enhancement of central respiratory drive.


Spinal Cord ◽  
2012 ◽  
Vol 50 (12) ◽  
pp. 895-898 ◽  
Author(s):  
F J Romero ◽  
C Gambarrutta ◽  
A Garcia-Forcada ◽  
M A Marín ◽  
E Diaz de la Lastra ◽  
...  

2020 ◽  
Vol 36 (6) ◽  
pp. 1307-1310
Author(s):  
Antonio Heredia Gutiérrez ◽  
Gabriel Emmanuel Cachón Cámara ◽  
Vicente González Carranza ◽  
Samuel Torres García ◽  
Fernando Chico Ponce de León

Sign in / Sign up

Export Citation Format

Share Document