Sacculated intracerebral aneurysm of the middle cerebral artery. A contribution to the knowledge of cerebral vascular malformations

1932 ◽  
Vol 35 (1) ◽  
pp. 19-28 ◽  
Author(s):  
W. H. Chase
Keyword(s):  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Vascular Malformations ◽  
Intracerebral Aneurysm ◽  
Cerebral Vascular Malformations ◽  
Cerebral Vascular

Unexpected Binding of Tozuleristide “Tumor Paint” to Cerebral Vascular Malformations: A Potentially Novel Application of Fluorescence-Guided Surgery

Neurosurgery ◽  
2021 ◽  
Author(s):  
Andrew J Kobets ◽  
David Nauen ◽  
Amy Lee ◽  
Alan R Cohen
Keyword(s):  
Near Infrared ◽  
Vascular Malformations ◽  
Cns Tumors ◽  
Matrix Metalloproteinase 2 ◽  
Cerebrovascular Lesions ◽  
Cavernous Malformations ◽  
Guided Surgery ◽  
Fluorescence Guided Surgery ◽  
Cerebral Vascular Malformations ◽  
Cerebral Vascular

Abstract BACKGROUND Fluorescence-guided surgery (FGS) is under investigation as a means to improve the extent of resection for primary central nervous system (CNS) tumors. Tozuleristide, known also as “Tumor Paint,” is an investigational tumor-targeting agent covalently conjugated to a derivative of the fluorescent dye indocyanine green. OBJECTIVE To report the finding of avid intraoperative fluorescence of tozuleristide on cerebral vascular malformations. METHODS Our institution is participating in a phase 2/3 study of intraoperative near-infrared fluorescence detection of pediatric primary CNS tumors in patients receiving intravenous tozuleristide and imaged with the Canvas system. Our site enrolled 2 patients with intracranial lesions, suspected preoperatively of possibly being gliomas that proved to be cavernous vascular malformations after resection. RESULTS Each lesion had a dark blue mulberry appearance and each fluoresced avidly with tozuleristide. Each was completely resected, and the patients recovered without deficit. Pathological assessment showed cavernous angioma for both cases. Tozuleristide fluorescence is postulated to result from binding to matrix metalloproteinase-2 and annexin A2, and literature review demonstrates expression of both these ligands on multiple cerebrovascular lesions, including cavernous malformations. CONCLUSION This finding deserves further investigation to determine if tozuleristide “Tumor Paint” may have a wider role in the identification of non-neoplastic intracranial pathologies.

Computed Tomography of Angiographically Occult Cerebral Vascular Malformations

Radiology ◽  
1977 ◽  
Vol 123 (3) ◽  
pp. 649-652 ◽  
Author(s):  
Richard A. Kramer ◽  
S. Douglas Wing
Keyword(s):  
Computed Tomography ◽  
Vascular Malformations ◽  
Cerebral Vascular Malformations ◽  
Cerebral Vascular

scholarly journals Loss of p53 Sensitizes Mice with a Mutation in Ccm1 (KRIT1) to Development of Cerebral Vascular Malformations

2004 ◽  
Vol 165 (5) ◽  
pp. 1509-1518 ◽  
Author(s):  
Nicholas W. Plummer ◽  
Carol J. Gallione ◽  
Sudha Srinivasan ◽  
Jon S. Zawistowski ◽  
David N. Louis ◽  
...  
Keyword(s):  
Vascular Malformations ◽  
Cerebral Vascular Malformations ◽  
Cerebral Vascular

scholarly journals Cerebral vascular malformations: Time-resolved CT angiography compared to DSA

2015 ◽  
Vol 28 (3) ◽  
pp. 310-315 ◽  
Author(s):  
Jai Jai Shiva Shankar ◽  
Cheemun Lum ◽  
Santanu Chakraborty ◽  
Marlise P dos Santos
Keyword(s):  
Ct Angiography ◽  
Vascular Malformations ◽  
Time Resolved ◽  
Cerebral Vascular Malformations ◽  
Cerebral Vascular
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