ε‐Aminocaproic acid versus tranexamic acid in children undergoing complex cranial vault reconstruction for repair of craniosynostosis

2021 ◽  
Author(s):  
Alexandra J. Borst ◽  
Christopher M. Bonfield ◽  
Poornachanda S. Deenadayalan ◽  
Chi H. Le ◽  
Meng Xu ◽  
...  
Keyword(s):  
Tranexamic Acid ◽  
Aminocaproic Acid ◽  
Cranial Vault ◽  
Acid Versus

Tranexamic acid versus aminocapróic acid in multiple doses via the oral route for the reduction of postoperative bleeding in total primary hip arthroplasty: a prospective, randomized, double-blind, controlled study

2021 ◽  
Vol 32 (2) ◽  
pp. 132-139
Author(s):  
Rodolfo Morales-Avalos ◽  
Tomas Ramos-Morales ◽  
Jesús A. García-Pedro ◽  
Ana M. Espinoza-Galindo ◽  
Carlos Acosta-Olivo ◽  
...  
Keyword(s):  
Tranexamic Acid ◽  
Hip Arthroplasty ◽  
Postoperative Bleeding ◽  
Aminocaproic Acid ◽  
Oral Route ◽  
Controlled Study ◽  
Double Blind ◽  
Acid Versus ◽  
Multiple Doses ◽  
Primary Hip Arthroplasty

scholarly journals ε-Aminocaproic acid (EACA) vs. tranexamic acid (TXA) in children undergoing complex cranial vault reconstruction for repair of craniosynostosis

2021 ◽  
Author(s):  
Alexandra Borst ◽  
Christopher Bonfield ◽  
Poornachanda Deenadayalan ◽  
Chi Le ◽  
Meng Xu ◽  
...  
Keyword(s):  
Blood Loss ◽  
Tranexamic Acid ◽  
Outcome Measures ◽  
Aminocaproic Acid ◽  
Cranial Vault ◽  
Secondary Outcome ◽  
Vascular Access Devices ◽  
Estimated Blood Loss ◽  
Transfusion Requirements ◽  
Significant Difference

INTRODUCTION: Children undergoing complex cranial vault reconstruction (CCVR) for craniosynostosis experience high rates of bleeding and transfusion, increasing risk for perioperative complications. ε-Aminocaproic acid (EACA) and tranexamic acid (TXA) are antifibrinolytic agents that have been shown to reduce intraoperative hemorrhage and transfusion requirements during CCVR. However, the relative efficacy of these two agents has not yet been evaluated. The aim of this study was to compare perioperative blood loss and transfusion rates in children receiving EACA vs. TXA. METHODS: All patients who underwent CCVR from September 2015 to December 2019 at a single center were retrospectively evaluated. Primary outcome measures included intraoperative estimated blood loss, postoperative drain output, transfusion volumes, and calculated blood loss. Secondary outcome measures included hematologic and coagulation parameters. RESULTS: 95 patients were included, with 47 patients in the EACA cohort and 48 patients in the TXA cohort. There were no significant differences in demographics, surgical outcomes, blood loss, transfusion requirement, or perioperative hematologic and coagulation laboratory values between the two cohorts. Adverse events were similar between the groups, but did include two seizure events and two thromboembolic events related to vascular access devices. DISCUSSION: We found no significant difference in blood loss, transfusion requirements, hematologic parameters, or outcomes between pediatric CCVR patients who received EACA vs. TXA. Further research is needed to define optimal antifibrinolytic dosing and duration of therapy. While standard laboratory parameters were similar between groups, future studies investigating coagulation-based and inflammatory assays may be useful in defining surgical-induced coagulopathy.

Efficacy and Safety of Tranexamic Acid Versus ϵ-Aminocaproic Acid in Cardiovascular Surgery

2014 ◽  
Vol 48 (12) ◽  
pp. 1563-1569 ◽  
Author(s):  
Olabisi Falana ◽  
Gourang Patel
Keyword(s):  
Tranexamic Acid ◽  
Cardiovascular Surgery ◽  
Aminocaproic Acid ◽  
Efficacy And Safety ◽  
Acid Versus

scholarly journals Tranexamic acid versus ɛ-aminocaproic acid: efficacy and safety in paediatric cardiac surgery

2011 ◽  
Vol 39 (6) ◽  
pp. 892-897 ◽  
Author(s):  
Klaus Martin ◽  
Tamás Breuer ◽  
Ralph Gertler ◽  
Alexander Hapfelmeier ◽  
Christian Schreiber ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Tranexamic Acid ◽  
Aminocaproic Acid ◽  
Efficacy And Safety ◽  
Acid Versus ◽  
Paediatric Cardiac Surgery

scholarly journals Epsilon-aminocaproic acid versus tranexamic acid in total knee arthroplasty: a meta-analysis study

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Osman Riaz ◽  
Adeel Aqil ◽  
Samir Asmar ◽  
Raees Vanker ◽  
James Hahnel ◽  
...  
Keyword(s):  
Total Knee Arthroplasty ◽  
Tranexamic Acid ◽  
Knee Arthroplasty ◽  
Meta Analysis ◽  
Aminocaproic Acid ◽  
Analysis Study ◽  
Acid Versus ◽  
Total Knee ◽  
Epsilon Aminocaproic Acid

scholarly journals Intravenous Tranexamic Acid Versus Topical Aminocaproic Acid: Which Method Has the Least Blood Loss and Transfusion Rates?

2018 ◽  
Vol 2 (11) ◽  
pp. e072
Author(s):  
Zachary C. Lum ◽  
Martin A. C. Manoukian ◽  
Christopher S. Pacheco ◽  
Alexander J. Nedopil ◽  
Mauro Giordani ◽  
...  
Keyword(s):  
Blood Loss ◽  
Tranexamic Acid ◽  
Aminocaproic Acid ◽  
Acid Versus

scholarly journals Blood Conservation Using Tranexamic Acid versus Epsilon Aminocaproic Acid in Cardiac Surgery: A Randomized Controlled Trial

2018 ◽  
Vol 5 (4) ◽  
pp. 169-175
Author(s):  
Jason Gatling ◽  
Davinder Ramsingh ◽  
Justin Horricks ◽  
Ryan Lauer ◽  
Stanley Brauer ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Cardiac Surgery ◽  
Tranexamic Acid ◽  
Controlled Trial ◽  
Aminocaproic Acid ◽  
Blood Conservation ◽  
Randomized Controlled ◽  
Acid Versus ◽  
Epsilon Aminocaproic Acid

scholarly journals Tranexamic acid versus aminocaproic acid for blood management after total knee and total hip arthroplasty: A systematic review and meta-analysis

2018 ◽  
Vol 54 ◽  
pp. 105-112 ◽  
Author(s):  
Qiuliang Liu ◽  
Peishuo Geng ◽  
Longyan Shi ◽  
Qi Wang ◽  
Pengliang Wang
Keyword(s):  
Systematic Review ◽  
Total Hip Arthroplasty ◽  
Tranexamic Acid ◽  
Hip Arthroplasty ◽  
Meta Analysis ◽  
Aminocaproic Acid ◽  
Blood Management ◽  
Total Hip ◽  
Acid Versus ◽  
Total Knee
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