scholarly journals Clinicopathological study of surgery for pulmonary metastases of hepatoblastoma with indocyanine green fluorescent imaging

2021 ◽  
Author(s):  
Misa Yoshida ◽  
Mio Tanaka ◽  
Norihiko Kitagawa ◽  
Kumiko Nozawa ◽  
Masato Shinkai ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Pulmonary Metastases ◽  
Fluorescent Imaging ◽  
Clinicopathological Study ◽  
Green Fluorescent

scholarly journals Clinicopathological study of surgery for pulmonary metastases of hepatoblastoma with indocyanine green fluorescent imaging

2021 ◽  
Author(s):  
Misa Yoshida ◽  
Mio Tanaka ◽  
Norihiko Kitagawa ◽  
Masato Shinkai ◽  
Hiroaki Goto ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Pulmonary Metastases ◽  
False Negative ◽  
Clinical Information ◽  
High Sensitivity ◽  
Fluorescent Imaging ◽  
Metastatic Lesions ◽  
Pulmonary Metastasectomies ◽  
Lung Metastasectomy ◽  
Green Fluorescent

Background: The prognosis of metastatic hepatoblastoma remains poor; to improve it, pulmonary metastasis must be controlled. Indocyanine green (ICG) fluorescent imaging has been used recently for lung metastasectomy. The objective of our study was to clarify the usefulness of ICG imaging for lung metastasectomy of hepatoblastoma using detailed clinicopathological analysis. Procedure: Patients with hepatoblastoma who underwent resection of pulmonary metastases with ICG fluorescent imaging were studied using retrospective analysis of clinical information, a review of their surgical records, and a histological analysis of their metastatic nodules. Results: Sixteen patients were enrolled. In total, 61 ICG-imaging-guided pulmonary metastasectomies were performed, and 350 ICG-positive and 23 ICG-negative specimens were identified. Tumors were confirmed in 250 of the ICG-positive specimens, including eight nonpalpable nodules, on microscopic examination. One hundred ICG-positive specimens and histologically tumor-negative specimens showed histological changes suggesting the regression of a tumor or bloodstream disturbance. The palpable ICG-negative tumors showed more-severe atypia than the ICG-positive tumors. Conclusions: This study demonstrates the high sensitivity of ICG imaging in detecting metastatic lesions of hepatoblastoma. Histological examinations suggested that ICG imaging detects not only tumor cells, but also nontumorous pulmonary tissues affected by bloodstream disturbance. Because a number of false-positive specimens were detected, further optimization of the dose of ICG and the timing of its administration may be required for thorough metastasectomy. Several false-negative specimens were also detected, suggesting the presence of ICG-negative metastatic tumors. Palpation during operation and imaging studies remain essential for detecting metastatic lesions, even in the era of ICG imaging.

Initial experience with a new quantitative assessment tool for fluorescent imaging in peripheral artery disease

VASA ◽  
2017 ◽  
Vol 46 (5) ◽  
pp. 383-388 ◽  
Author(s):  
Henrik Christian Rieß ◽  
Anna Duprée ◽  
Christian-Alexander Behrendt ◽  
Tilo Kölbel ◽  
Eike Sebastian Debus ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Quantitative Assessment ◽  
Tissue Perfusion ◽  
Fluorescent Imaging ◽  
Peripheral Artery ◽  
Peripheral Bypass ◽  
Before And After ◽  
Artery Disease ◽  
Green Fluorescent ◽  
Peripheral Bypass Grafting

Abstract. Background: Perioperative evaluation in peripheral artery disease (PAD) by common vascular diagnostic tools is limited by open wounds, medial calcinosis or an altered collateral supply of the foot. Indocyanine green fluorescent imaging (ICG-FI) has recently been introduced as an alternative tool, but so far a standardized quantitative assessment of tissue perfusion in vascular surgery has not been performed for this purpose. The aim of this feasibility study was to investigate a new software for quantitative assessment of tissue perfusion in patients with PAD using indocyanine green fluorescent imaging (ICG-FI) before and after peripheral bypass grafting. Patients and methods: Indocyanine green fluorescent imaging was performed in seven patients using the SPY Elite system before and after peripheral bypass grafting for PAD (Rutherford III-VI). Visual and quantitative evaluation of tissue perfusion was assessed in an area of low perfusion (ALP) and high perfusion (AHP), each by three independent investigators. Data assessment was performed offline using a specially customized software package (Institute for Laser Technology, University Ulm, GmbH). Slope of fluorescent intensity (SFI) was measured as time-intensity curves. Values were compared to ankle-brachial index (ABI), slope of oscillation (SOO), and time to peak (TTP) obtained from photoplethysmography (PPG). Results: All measurements before and after surgery were successfully performed, showing that ABI, TTP, and SOO increased significantly compared to preoperative values, all being statistically significant (P < 0.05), except for TTP (p = 0.061). Further, SFI increased significantly in both ALP and AHP (P < 0.05) and correlated considerably with ABI, TTP, and SOO (P < 0.05). Conclusions: In addition to ABI and slope of oscillation (SOO), the ICG-FI technique allows visual assessment in combination with quantitative assessment of tissue perfusion in patients with PAD. Ratios related to different perfusion patterns and SFI seem to be useful tools to reduce factors disturbing ICG-FI measurements.

scholarly journals Real-time identification of liver cancers by using indocyanine green fluorescent imaging

Cancer ◽  
2009 ◽  
Vol 115 (11) ◽  
pp. 2491-2504 ◽  
Author(s):  
Takeaki Ishizawa ◽  
Noriyoshi Fukushima ◽  
Junji Shibahara ◽  
Koichi Masuda ◽  
Sumihito Tamura ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Real Time ◽  
Fluorescent Imaging ◽  
Liver Cancers ◽  
Real Time Identification ◽  
Green Fluorescent

Complete Removal of Adrenal Metastasis in Hepatocellular Carcinoma Using Indocyanine Green Fluorescent Imaging

2020 ◽  
Vol 40 (10) ◽  
pp. 5823-5828
Author(s):  
KENSUKE YAMAMURA ◽  
TORU BEPPU ◽  
NOBUTAKA SATO ◽  
KOICHI KINOSHITA ◽  
ERI ODA ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Indocyanine Green ◽  
Complete Removal ◽  
Adrenal Metastasis ◽  
Fluorescent Imaging ◽  
Green Fluorescent

Indocyanine Green Fluorescent Imaging for Hepatic Resection of the Right Hepatic Vein Drainage Area

2015 ◽  
Vol 221 (3) ◽  
pp. e49-e53 ◽  
Author(s):  
Takeshi Kurihara ◽  
Yo-ichi Yamashita ◽  
Yoshihiro Yoshida ◽  
Kazuki Takeishi ◽  
Shinji Itoh ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Hepatic Resection ◽  
Hepatic Vein ◽  
Fluorescent Imaging ◽  
Drainage Area ◽  
Green Fluorescent ◽  
The Right ◽  
Right Hepatic Vein

Using indocyanine green fluorescent imaging to successfully resect metachronous regional lymph node recurrence of rectosigmoid cancer

2017 ◽  
Vol 11 (1) ◽  
pp. 47-49 ◽  
Author(s):  
Koichi Tamura ◽  
Tsukasa Hotta ◽  
Shozo Yokoyama ◽  
Kenji Matsuda ◽  
Hiromitsu Iwamoto ◽  
...  
Keyword(s):  
Lymph Node ◽  
Indocyanine Green ◽  
Regional Lymph Node ◽  
Fluorescent Imaging ◽  
Rectosigmoid Cancer ◽  
Lymph Node Recurrence ◽  
Green Fluorescent

Hepatic resection for the right hepatic vein drainage area with indocyanine green fluorescent imaging navigation

2020 ◽  
Vol 27 (7) ◽  
pp. 371-379
Author(s):  
Norio Kubo ◽  
Kenichiro Araki ◽  
Norifumi Harimoto ◽  
Norihiro Ishii ◽  
Mariko Tsukagoshi ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Hepatic Resection ◽  
Hepatic Vein ◽  
Fluorescent Imaging ◽  
Drainage Area ◽  
Green Fluorescent ◽  
The Right ◽  
Right Hepatic Vein

PS01.206: ASSESSMENT OF THE GASTRIC CONDUIT RECONSTRUCTION USING INDOCYANINE GREEN FLUORESCENT IMAGING DURING ESOPHAGECTOMY

2018 ◽  
Vol 31 (Supplement_1) ◽  
pp. 108-108
Author(s):  
Takumi Yamabuki ◽  
Masanori Ohara ◽  
Tsukasa Kaneko ◽  
Aki Fujiwara ◽  
Ryou Takahashi ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Anastomotic Leakage ◽  
Conflicts Of Interest ◽  
Circular Stapler ◽  
Transhiatal Esophagectomy ◽  
Gastric Conduit ◽  
Fluorescent Imaging ◽  
Esophageal Dilatation ◽  
Anastomosis Site ◽  
Green Fluorescent

Abstract Background Recently, indocyanine green (ICG) fluorescent imaging has been applied as a real-time navigation tool in various surgical fields. We used ICG fluorescent imaging for gastric conduit reconstruction during esophagectomy. Methods A total of 92 consecutive patients with esophageal cancer who received gastric conduit reconstruction during esophagectomy from February 2011 to December 2017 were enrolled in the present study. We made gastric conduit with hand-assisted laparoscopic surgery (HALS) following esophagectomy. A gastric conduit with a width of 3cm was usually fashioned. After evaluation of the blood flow to the gastric conduit using ICG fluorescent imaging, anastomosis was done by circular stapler. Results The study group was comprised of 73 males and 19 females and the median age was 70 years (range 54–85 years). Nineteen patients received preoperative chemotherapy and eleven patients received preoperative chemo-radiotherapy. Forty-eight patients underwent thoracoscopic esophagectomy, nineteen patients underwent thoracotomy and twenty-five patients underwent laparoscope assisted transhiatal esophagectomy. In eighty-five patients, reconstruction was done via the posterior mediastinal route, while six patients ware treated by the retrosternal route, and the subcutaneous route was used in one patient. Cervical anastomosis was done in 84 patients and intrathoracic anastomosis was done in eight patients. The complications of the gastric conduit reconstruction were anastomotic leakage in one (1.1%) patient and stricture of the anastomosis site requiring esophageal dilatation in 26 (28.3%) patients. Periodic esophageal dilatation was done in 13 (14.1%) patients. There was one case of stricture of the gastric conduit, one case of bleeding of the gastric conduit and one case of fistula between the gastric conduit and the lung. Conclusion The gastric conduit reconstruction using ICG fluorescent imaging during esophagectomy may contribute to a reduction in the incidence of anastomotic leakage. However, further advancement of the relevant skills is required to improve the incidence of stricture of the anastomosis site. Disclosure All authors have declared no conflicts of interest.

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