Comparison of the effects of diclofenac or other non-steroidal anti-inflammatory drugs (NSAIDs) and diclofenac or other NSAIDs in combination with proton pump inhibitors (PPI) on hospitalisation due to peptic ulcer disease

2007 ◽  
Vol 16 (8) ◽  
pp. 854-858 ◽  
Author(s):  
Ariane Höer ◽  
Holger Gothe ◽  
Guido Schiffhorst ◽  
Astrid Sterzel ◽  
Ulrich Grass ◽  
...  
Keyword(s):  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Ulcer Disease ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Proton Pump Inhibition is a Feasible Primary Alternative to Surgery and Balloon Dilatation in Adult Peptic Pyloric Stenosis (APS): Report of Six Consecutive Cases

2006 ◽  
Vol 88 (2) ◽  
pp. 174-175 ◽  
Author(s):  
J Shabbir ◽  
S Durrani ◽  
PF Ridgway ◽  
K Mealy
Keyword(s):  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Pyloric Stenosis ◽  
Median Duration ◽  
Oral Treatment ◽  
Duration Of Symptoms ◽  
Ulcer Disease ◽  
Proton Pump Inhibition

INTRODUCTION Surgery has been the gold standard in the treatment of adult pyloric stenosis (APS). The introduction of proton pump inhibitors (PPIs) in 1989 revolutionised the treatment of peptic ulcer disease and its complications. PATIENTS AND METHODS We carried out a prospective study to evaluate the effectiveness of PPIs as an alternative to surgery for treatment of APS. Six consecutive patients admitted with a diagnosis of adult peptic pyloric stenosis between November 1999 and August 2002 were studied. The diagnosis was confirmed with endoscopy. All patients were commenced on a twice-daily dose of intravenous PPI. This was changed to oral treatment after 2 days. Main outcome measures evaluated were resolution of symptoms on PPIs and failure of medical therapy. RESULTS There were five females and one male. Median age at diagnosis was 72 years (range, 30–90 years). Median duration of symptoms was 2 weeks (range, 1–5 weeks). Of the patients, five had a history of peptic ulcer disease. Complete resolution was achieved in 5 patients (83%). Median duration for resolution of symptoms was 9 days (range, 5–14 days). All patients were changed to oral PPIs after 2 days. One patient did not respond to oral therapy and required surgical intervention (pyloroplasty). Median follow-up was 26 months (range, 6–48 months). There was no recurrence of symptoms. All patients were discharged on low-dose PPI. CONCLUSIONS This study supports the view that proton pump inhibitors are a safe and feasible alternative to surgery in adult pyloric stenosis secondary to peptic ulcer disease.

1226 Under-Utilization of Proton Pump Inhibitors in the Prevention of NSAID-Related Peptic Ulcer Disease in the Elderly

2019 ◽  
Vol 114 (1) ◽  
pp. S684-S684
Author(s):  
Ahmad M. Al-Taee ◽  
Elie Ghoulam ◽  
Preston Lee ◽  
Robert Sbertoli ◽  
Christine Hachem
Keyword(s):  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
The Elderly ◽  
Ulcer Disease

THE ASSOCIATION OF HELICOBACTER PYLORI INFECTION AND NON-STEROIDAL ANTI-INFLAMMATORY DRUGS IN PEPTIC-ULCER DISEASE

2004 ◽  
Vol 99 ◽  
pp. S44
Author(s):  
Juan C. Zapata-Colindres ◽  
Sergio Zepeda-Gomez ◽  
Aldo Montano-Loza ◽  
Edgar Vazquez-Ballesteros ◽  
Francisco Valdovinos-Andraca
Keyword(s):  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Peptic Ulcer Disease ◽  
Helicobacter Pylori Infection ◽  
Ulcer Disease ◽  
Inflammatory Drugs ◽  
Anti Inflammatory
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