Surfactant Protein D is a Biomarker of Influenza‐Related Pediatric Lung Injury

2021 ◽  
Author(s):  
Arindam Chakrabarti ◽  
Allen Nguyen ◽  
Margaret M. Newhams ◽  
Maikke B. Ohlson ◽  
Xiaoying Yang ◽  
...  
Keyword(s):  
Lung Injury ◽  
Surfactant Protein ◽  
Surfactant Protein D

scholarly journals Alveolar Surfactant Protein D Content Modulates Bleomycin-induced Lung Injury

2005 ◽  
Vol 172 (7) ◽  
pp. 869-877 ◽  
Author(s):  
John Casey ◽  
Jennifer Kaplan ◽  
Elena N. Atochina-Vasserman ◽  
Andrew J. Gow ◽  
Helchem Kadire ◽  
...  
Keyword(s):  
Lung Injury ◽  
Surfactant Protein ◽  
Surfactant Protein D ◽  
Alveolar Surfactant

Surfactant Protein D Variants in Sepsis-Induced Lung Injury Following Ozone Exposure

2019 ◽  
Author(s):  
J.M. Radbel ◽  
K. Vayas ◽  
E. Abramova ◽  
O. Le-Hoang ◽  
V. Sunil ◽  
...  
Keyword(s):  
Lung Injury ◽  
Surfactant Protein ◽  
Ozone Exposure ◽  
Surfactant Protein D

The Diagnostic Value Of Serum Level Of Surfactant Protein D For The Degree Of Fibrosis After Bleomycin-Induced Lung Injury In Mouse

2012 ◽  
Author(s):  
Shigeki Chiba ◽  
Shinya Ohkouchi ◽  
Manabu Ono ◽  
kyoko Abe ◽  
Shu Hisata ◽  
...  
Keyword(s):  
Serum Level ◽  
Lung Injury ◽  
Surfactant Protein ◽  
Diagnostic Value ◽  
Surfactant Protein D

Alterations In Multimeric Structure Of Surfactant Protein D As A Biomarker For Lung Injury And Inflammation In Humans

2010 ◽  
Author(s):  
Elena N. Atochina-Vasserman ◽  
Jens Hohlfeld ◽  
Helena Abramova ◽  
Karen Sims ◽  
Carla Winkler ◽  
...  
Keyword(s):  
Lung Injury ◽  
Surfactant Protein ◽  
Surfactant Protein D

Differential modulation of surfactant protein D under acute and persistent hypoxia in acute lung injury

2012 ◽  
Vol 303 (1) ◽  
pp. L43-L53 ◽  
Author(s):  
Koji Sakamoto ◽  
Naozumi Hashimoto ◽  
Yasuhiro Kondoh ◽  
Kazuyoshi Imaizumi ◽  
Daisuke Aoyama ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Molecular Mechanisms ◽  
De Novo ◽  
Acute Hypoxia ◽  
Surfactant Protein ◽  
Surfactant Protein D ◽  
Alveolar Cells ◽  
Mesenchymal Transition ◽  
Twist Expression

Hypoxia contributes to the development of fibrosis with epithelial-mesenchymal transition (EMT) via stimulation of hypoxia-inducible factor 1α (HIF-1α) and de novo twist expression. Although hypoxemia is associated with increasing levels of surfactant protein D (SP-D) in acute lung injury (ALI), the longitudinal effects of hypoxia on SP-D expression in lung tissue injury/fibrosis have not been fully evaluated. Here, the involvement of hypoxia and SP-D modulation was evaluated in a model of bleomycin-induced lung injury. We also investigated the molecular mechanisms by which hypoxia might modulate SP-D expression in alveolar cells, by using a doxycycline (Dox)-dependent HIF-1α expression system. Tissue hypoxia and altered SP-D levels were present in bleomycin-induced fibrotic lesions. Acute hypoxia induced SP-D expression, supported by the finding that Dox-induced expression of HIF-1α increased SP-D expression. In contrast, persistent hypoxia repressed SP-D expression coupled with an EMT phenotype and twist expression. Long-term expression of HIF-1α caused SP-D repression with twist expression. Ectopic twist expression repressed SP-D expression. The longitudinal observation of hypoxia and SP-D levels in ALI in vivo was supported by the finding that HIF-1α expression stabilized by acute hypoxia induced increasing SP-D expression in alveolar cells, whereas persistent hypoxia induced de novo twist expression in these cells, causing repression of SP-D and acquisition of an EMT phenotype. Thus this is the first study to demonstrate the molecular mechanisms, in which SP-D expression under acute and persistent hypoxia in acute lung injury might be differentially modulated by stabilized HIF-1α expression and de novo twist expression.

scholarly journals S‐Nitrosylation of Surfactant Protein D (SP‐D) modulates its oligomerization and inflammatory function in vitro and in experimental models of lung injury.

2007 ◽  
Vol 21 (5) ◽  
Author(s):  
Elena N Atochina‐Vasserman ◽  
Helen Abramova ◽  
Yaniv Tomer ◽  
Helchem Kadire ◽  
Deepika Jain ◽  
...  
Keyword(s):  
Lung Injury ◽  
Surfactant Protein ◽  
Experimental Models ◽  
Surfactant Protein D

scholarly journals Surfactant Protein D Protects Against Hyperoxia‐Induced Acute Lung Injury In A Murine Model

2006 ◽  
Vol 20 (5) ◽  
Author(s):  
Deepika Jain ◽  
Elena N. Atochina‐Vasserman ◽  
Helchem Kadire ◽  
Yaniv Tomer ◽  
Adam Inch ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Murine Model ◽  
Surfactant Protein ◽  
Surfactant Protein D

scholarly journals Surfactant Protein D Deficiency Increases Lung Injury during Endotoxemia

2011 ◽  
Vol 44 (5) ◽  
pp. 709-715 ◽  
Author(s):  
Brooke A. King ◽  
Paul S. Kingma
Keyword(s):  
Lung Injury ◽  
Surfactant Protein ◽  
Surfactant Protein D
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