Crystal structure of TTHA0303 (TT2238), a four‐helix bundle protein with an exposed histidine triad from Thermus thermophilus HB8 at 2.0 Å

2008 ◽  
Vol 70 (3) ◽  
pp. 1103-1107 ◽  
Author(s):  
Koji Nagata ◽  
Jun Ohtsuka ◽  
Mihoko Takahashi ◽  
Atsuko Asano ◽  
Hitoshi Iino ◽  
...  
2004 ◽  
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Kazutaka Murayama ◽  
Mio Inoue ◽  
Takaho Terada ◽  
Jeremy R.H. Tame ◽  
...  

2006 ◽  
Vol 64 (2) ◽  
pp. 552-558 ◽  
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Chizuko Sasaki ◽  
Ikuko Sugiura ◽  
Akio Ebihara ◽  
Takashi Tamura ◽  
Shigetoshi Sugio ◽  
...  

2004 ◽  
Vol 279 (19) ◽  
pp. 20511-20518 ◽  
Author(s):  
Sheng Ye ◽  
Ioannis Vakonakis ◽  
Thomas R. Ioerger ◽  
Andy C. LiWang ◽  
James C. Sacchettini

The circadian clock found inSynechococcus elongatus, the most ancient circadian clock, is regulated by the interaction of three proteins, KaiA, KaiB, and KaiC. While the precise function of these proteins remains unclear, KaiA has been shown to be a positive regulator of the expression of KaiB and KaiC. The 2.0-Å structure of KaiA ofS. elongatusreported here shows that the protein is composed of two independently folded domains connected by a linker. The NH2-terminalpseudo-receiver domain has a similar fold with that of bacterial response regulators, whereas the COOH-terminal four-helix bundle domain is novel and forms the interface of the 2-fold-related homodimer. The COOH-terminal four-helix bundle domain has been shown to contain the KaiC binding site. The structure suggests that the KaiB binding site is covered in the dimer interface of the KaiA “closed” conformation, observed in the crystal structure, which suggests an allosteric regulation mechanism.


2008 ◽  
Vol 73 (4) ◽  
pp. 1053-1057 ◽  
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Akihiro Yamamura ◽  
Jun Ohtsuka ◽  
Keiko Kubota ◽  
Yoshihiro Agari ◽  
Akio Ebihara ◽  
...  

2010 ◽  
Vol 24 (S1) ◽  
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Thomas J. Magliery ◽  
Jason J. Lavinder ◽  
Sanjay B. Hari ◽  
Chau Nguyen ◽  
Shila Sen

2013 ◽  
Vol 53 (supplement1-2) ◽  
pp. S226
Author(s):  
Hiroya Niiro ◽  
Satoshi Akanuma ◽  
Akihiko Yamagishi ◽  
Yuuto Akiyama ◽  
Tatuya Uchida

2008 ◽  
Vol 73 (1) ◽  
pp. 259-264 ◽  
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Rihito Morita ◽  
Hirohito Ishikawa ◽  
Noriko Nakagawa ◽  
Seiki Kuramitsu ◽  
Ryoji Masui

2005 ◽  
Vol 61 (4) ◽  
pp. 1117-1120 ◽  
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...  

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