A glutamate concentration‐biased allosteric modulator potentiates NMDA‐induced ion influx in neurons

Blaise M. Costa; Lina Cortés Kwapisz; Brittney Mehrkens; Douglas N. Bledsoe; Bryanna N. Vacca; Tullia V. Johnston; Rehan Razzaq; Dhanasekaran Manickam; Bradley G. Klein

doi:10.1002/prp2.859

A glutamate concentration‐biased allosteric modulator potentiates NMDA‐induced ion influx in neurons

Pharmacology Research & Perspectives ◽

10.1002/prp2.859 ◽

2021 ◽

Vol 9 (5) ◽

Author(s):

Blaise M. Costa ◽

Lina Cortés Kwapisz ◽

Brittney Mehrkens ◽

Douglas N. Bledsoe ◽

Bryanna N. Vacca ◽

...

Keyword(s):

Allosteric Modulator ◽

Glutamate Concentration ◽

Ion Influx

Correction: Structural modeling and role of HAX-1 as a positive allosteric modulator of human serine protease HtrA2

Biochemical Journal ◽

10.1042/bcj-2019-0569_cor ◽

2020 ◽

Vol 477 (2) ◽

pp. 459-459

Author(s):

Lalith K. Chaganti ◽

Shubhankar Dutta ◽

Raja Reddy Kuppili ◽

Mriganka Mandal ◽

Kakoli Bose

Keyword(s):

Serine Protease ◽

Structural Modeling ◽

Allosteric Modulator ◽

Positive Allosteric Modulator

The effect of mGluR2 3 agonist, LY379268, and a mGluR4 positive allosteric modulator, VU0155041, on conditioned taste aversion

10.32469/10355/40222 ◽

2013 ◽

Author(s):

Diana Klakotskaia

Keyword(s):

Taste Aversion ◽

Conditioned Taste Aversion ◽

Allosteric Modulator ◽

Positive Allosteric Modulator

Faculty Opinions recommendation of Intravenous glutamine supplementation to head trauma patients leaves cerebral glutamate concentration unaffected.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1046404.496366 ◽

2006 ◽

Author(s):

Basil Matta

Keyword(s):

Head Trauma ◽

Glutamine Supplementation ◽

Trauma Patients ◽

Glutamate Concentration

Faculty Opinions recommendation of Fragment and Structure-Based Drug Discovery for a Class C GPCR: Discovery of the mGlu5 Negative Allosteric Modulator HTL14242 (3-Chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile).

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725689130.793508968 ◽

2015 ◽

Author(s):

John Lowe

Keyword(s):

Drug Discovery ◽

Allosteric Modulator ◽

Negative Allosteric Modulator ◽

Class C

Faculty Opinions recommendation of Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725679098.793542278 ◽

2018 ◽

Author(s):

Bernard Le Foll

Keyword(s):

Cb1 Receptor ◽

Allosteric Modulator ◽

Cannabinoid Cb1 Receptor ◽

Negative Allosteric Modulator

Faculty Opinions recommendation of An mGlu5-Positive Allosteric Modulator Rescues the Neuroplasticity Deficits in a Genetic Model of NMDA Receptor Hypofunction in Schizophrenia.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726061211.793515244 ◽

2016 ◽

Author(s):

Leslie Iversen

Keyword(s):

Nmda Receptor ◽

Genetic Model ◽

Allosteric Modulator ◽

Positive Allosteric Modulator

Faculty Opinions recommendation of A Phase 2A Trial of the Novel mGluR5-Negative Allosteric Modulator Dipraglurant for Levodopa-Induced Dyskinesia in Parkinson's Disease.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726375502.793520446 ◽

2016 ◽

Author(s):

Joseph Jankovic ◽

Mary Ann Thenganatt

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Allosteric Modulator ◽

The Novel ◽

Negative Allosteric Modulator

Faculty Opinions recommendation of Neuroactive Steroids. 2. 3α-Hydroxy-3β-methyl-21-(4-cyano-1H-pyrazol-1'-yl)-19-nor-5β-pregnan-20-one (SAGE-217): A Clinical Next Generation Neuroactive Steroid Positive Allosteric Modulator of the (γ-Aminobutyric Acid)A Receptor.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.727847766.793560292 ◽

2019 ◽

Author(s):

Hanns Möhler

Keyword(s):

Neuroactive Steroids ◽

Aminobutyric Acid ◽

Allosteric Modulator ◽

Neuroactive Steroid ◽

Next Generation ◽

Positive Allosteric Modulator

Faculty Opinions recommendation of Allosteric Modulator Discovery: From Serendipity to Structure-Based Design.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.735179621.793557333 ◽

2019 ◽

Author(s):

Jean-Pierre Changeux

Keyword(s):

Allosteric Modulator

para-Trifluoromethyl-methcathinone is an allosteric modulator of the serotonin transporter

Neuropharmacology ◽

10.1016/j.neuropharm.2019.04.021 ◽

2019 ◽

Vol 161 ◽

pp. 107615 ◽

Cited By ~ 2

Author(s):

Marco Niello ◽

Daniela Cintulova ◽

Eva Hellsberg ◽

Kathrin Jäntsch ◽

Marion Holy ◽

...

Keyword(s):

Serotonin Transporter ◽

Allosteric Modulator