Integration of Physiologically‐Based Pharmacokinetic Modeling into Early Clinical Development: An Investigation of the Pharmacokinetic Nonlinearity

Clinical Development ◽

Physiologically Based ◽

Early Clinical Development

Model-Based Assessments of CYP-Mediated Drug-Drug Interaction Risk of Alectinib: Physiologically Based Pharmacokinetic Modeling Supported Clinical Development

Clinical Pharmacology & Therapeutics ◽

10.1002/cpt.956 ◽

2017 ◽

Vol 104 (3) ◽

pp. 505-514 ◽

Cited By ~ 4

Author(s):

Yumi Cleary ◽

Michael Gertz ◽

Peter N. Morcos ◽

Li Yu ◽

Kuresh Youdim ◽

...

Keyword(s):

Drug Interaction ◽

Clinical Development ◽

Model Based ◽

Physiologically Based ◽

Drug Drug Interaction

Utilizing Physiologically Based Pharmacokinetic Modeling to Inform Formulation and Clinical Development for a Compound with pH-Dependent Solubility

Journal of Pharmaceutical Sciences ◽

10.1002/jps.24339 ◽

2015 ◽

Vol 104 (4) ◽

pp. 1522-1532 ◽

Cited By ~ 12

Author(s):

John Chung ◽

Fernando Alvarez-Nunez ◽

Vincent Chow ◽

Dominick Daurio ◽

John Davis ◽

...

Keyword(s):

Clinical Development ◽

Physiologically Based ◽

Ph Dependent

Accelerating clinical development of idasanutlin through a physiologically-based pharmacokinetic modeling risk assessment for CYP450 isoenzyme related drug-drug interactions

Drug Metabolism and Disposition ◽

10.1124/dmd.121.000720 ◽

2021 ◽

pp. DMD-AR-2021-000720

Author(s):

Kenichi Umehara ◽

Yumi Cleary ◽

Stephen Fowler ◽

Neil Parrott ◽

Dietrich W. Tuerck

Keyword(s):

Risk Assessment ◽

Drug Interactions ◽

Clinical Development ◽

Physiologically Based ◽

Related Drug

Physiologically-based pharmacokinetic modeling of different size polyethylene glycol-coated gold nanoparticles in mice

10.1615/ihtc16.nmt.023362 ◽

2018 ◽

Author(s):

Linjing Deng ◽

Jinping Zhao ◽

Yufeng Miao ◽

Xu Hu ◽

Qihong Deng

Keyword(s):

Gold Nanoparticles ◽

Polyethylene Glycol ◽

Physiologically-Based Pharmacokinetic Modeling to Predict Changes in Drug Exposure during Pregnancy Using the Simcyp Simulator

10.26226/morressier.57d6b2b7d462b8028d88e945 ◽

2016 ◽

Author(s):

Suvarchala Kiranmai Avvari

Keyword(s):

Drug Exposure ◽

Physiologically Based ◽

Exposure During Pregnancy

Physiologically‐Based Pharmacokinetic Modeling of Atorvastatin Incorporating Delayed Gastric Emptying and Acid‐to‐Lactone Conversion

CPT Pharmacometrics & Systems Pharmacology ◽

10.1002/psp4.12447 ◽

2019 ◽

Vol 8 (9) ◽

pp. 664-675 ◽

Cited By ~ 5

Author(s):

Bridget L. Morse ◽

Jeffrey J. Alberts ◽

Maria M. Posada ◽

Jessica Rehmel ◽

Anil Kolur ◽

...

Keyword(s):

Gastric Emptying ◽

Delayed Gastric Emptying ◽

Preliminary physiologically based pharmacokinetic modeling of renally cleared drugs in Chinese pregnant women

Biopharmaceutics & Drug Disposition ◽

10.1002/bdd.2243 ◽

2020 ◽

Vol 41 (6) ◽

pp. 248-267 ◽

Cited By ~ 1

Author(s):

Ling Song ◽

Zhiheng Yu ◽

Yifan Xu ◽

Xiaobei Li ◽

Xuanlin Liu ◽

...

Keyword(s):

Pregnant Women ◽

Prediction of fluoxetine and norfluoxetine pharmacokinetic profiles using physiologically based pharmacokinetic modeling

The Journal of Clinical Pharmacology ◽

10.1002/jcph.1927 ◽

2021 ◽

Author(s):

Hyeon‐Cheol Jeong ◽

Yoon‐Jee Chae ◽

Sooyeun Lee ◽

Wonku Kang ◽

Hwi‐yeol Yun ◽

...

Keyword(s):

Pharmacokinetic Profiles ◽

Physiologically Based Pharmacokinetic Modeling Approach to Predict Drug‐Drug Interactions With Ethionamide Involving Impact of Genetic Polymorphism on FMO3

The Journal of Clinical Pharmacology ◽

10.1002/jcph.1378 ◽

2019 ◽

Vol 59 (6) ◽

pp. 880-889 ◽

Cited By ~ 1

Author(s):

Phuong Thi Thu Nguyen ◽

Md Masud Parvez ◽

Min Jung Kim ◽

Sung Eun Yoo ◽

Sangzin Ahn ◽

...

Keyword(s):

Genetic Polymorphism ◽

Drug Interactions ◽

Modeling Approach ◽

Physiologically Based Pharmacokinetic Modeling and Tissue Distribution Characteristics of SHetA2 in Tumor-Bearing Mice

The AAPS Journal ◽

10.1208/s12248-020-0421-z ◽

2020 ◽

Vol 22 (2) ◽

Author(s):

Ankur Sharma ◽

Mengjie Li ◽

Elangovan Thavathiru ◽

Mariam Ibrahim ◽

Lucila Garcia-Contreras ◽

...

Keyword(s):

Tissue Distribution ◽

Distribution Characteristics ◽

Tumor Bearing ◽