scholarly journals Matrix ions as internal standard for high mass accuracy MALDI mass spectrometry imaging

2021 ◽  
Author(s):  
Axel Treu ◽  
Andreas Römpp
Keyword(s):  
Mass Spectrometry ◽  
Mass Spectrometry Imaging ◽  
Internal Standard ◽  
Maldi Mass Spectrometry ◽  
Mass Accuracy ◽  
High Mass ◽  
High Mass Accuracy ◽  
Maldi Mass Spectrometry Imaging

High-mass-resolution MALDI mass spectrometry imaging of metabolites from formalin-fixed paraffin-embedded tissue

2016 ◽  
Vol 11 (8) ◽  
pp. 1428-1443 ◽  
Author(s):  
Alice Ly ◽  
Achim Buck ◽  
Benjamin Balluff ◽  
Na Sun ◽  
Karin Gorzolka ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Mass Spectrometry Imaging ◽  
Maldi Mass Spectrometry ◽  
Mass Resolution ◽  
High Mass ◽  
Formalin Fixed Paraffin ◽  
High Mass Resolution ◽  
Formalin Fixed Paraffin Embedded ◽  
Formalin Fixed ◽  
Maldi Mass Spectrometry Imaging

scholarly journals Ultra-High Mass Resolving Power, Mass Accuracy, and Dynamic Range MALDI Mass Spectrometry Imaging by 21-T FT-ICR MS

2020 ◽  
Vol 92 (4) ◽  
pp. 3133-3142 ◽  
Author(s):  
Andrew P. Bowman ◽  
Greg T. Blakney ◽  
Christopher L. Hendrickson ◽  
Shane R. Ellis ◽  
Ron M. A. Heeren ◽  
...  
Keyword(s):  
Mass Spectrometry Imaging ◽  
Dynamic Range ◽  
Maldi Mass Spectrometry ◽  
Mass Accuracy ◽  
Resolving Power ◽  
High Mass ◽  
Mass Resolving Power ◽  
Ft Icr Ms ◽  
Maldi Mass Spectrometry Imaging ◽  
Ft Icr

scholarly journals Detecting Proteomic Indicators to Distinguish Diabetic Nephropathy from Hypertensive Nephrosclerosis by Integrating Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging with High-Mass Accuracy Mass Spectrometry

2020 ◽  
Vol 45 (2) ◽  
pp. 233-248 ◽  
Author(s):  
Andrew Smith ◽  
Vadim Iablokov ◽  
Mariafrancesca Mazza ◽  
Sonia Guarnerio ◽  
Vanna Denti ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Mass Spectrometry Imaging ◽  
Laser Desorption ◽  
Mass Accuracy ◽  
High Mass ◽  
High Mass Accuracy ◽  
Hypertensive Nephrosclerosis ◽  
Preliminary Study ◽  
Matrix Assisted Laser ◽  
Matrix Assisted Laser Desorption

Introduction: Diabetic nephropathy (DN) and hypertensive nephrosclerosis (HN) represent the most common causes of chronic kidney disease (CKD) and many patients progress to ­end-stage renal disease. Patients are treated primarily through the management of cardiovas­cular risk factors and hypertension; however patients with HN have a more favorable outcome. A noninvasive clinical approach to separate these two entities, especially in hypertensive patients who also have diabetes, would allow for targeted treatment and more appropriate resource allocation to those patients at the highest risk of CKD progression. Meth­ods: In this preliminary study, high-spatial-resolution matrix-assisted laser desorption/ion­ization (MALDI) mass spectrometry imaging (MSI) was integrated with high-mass accuracy MALDI-FTICR-MS and nLC-ESI-MS/MS analysis in order to detect tissue proteins within kidney biopsies to discriminate cases of DN (n = 9) from cases of HN (n = 9). Results: Differences in the tryptic peptide profiles of the 2 groups could clearly be detected, with these becoming even more evident in the more severe histological classes, even if this was not evident with routine histology. In particular, 4 putative proteins were detected and had a higher signal intensity within regions of DN tissue with extensive sclerosis or fibrosis. Among these, 2 proteins (PGRMC1 and CO3) had a signal intensity that increased at the latter stages of the disease and may be associated with progression. Discussion/Conclusion: This preliminary study represents a valuable starting point for a future study employing a larger cohort of patients to develop sensitive and specific protein biomarkers that could reliably differentiate between diabetic and hypertensive causes of CKD to allow for improved diagnosis, fewer biopsy procedures, and refined treatment approaches for clinicians.

scholarly journals High-mass-resolution MALDI mass spectrometry imaging reveals detailed spatial distribution of metabolites and lipids in roots of barley seedlings in response to salinity stress

Metabolomics ◽  
2018 ◽  
Vol 14 (5) ◽  
Author(s):  
Lenin D. Sarabia ◽  
Berin A. Boughton ◽  
Thusitha Rupasinghe ◽  
Allison M. L. van de Meene ◽  
Damien L. Callahan ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Spatial Distribution ◽  
Salinity Stress ◽  
Mass Spectrometry Imaging ◽  
Maldi Mass Spectrometry ◽  
Mass Resolution ◽  
High Mass ◽  
High Mass Resolution ◽  
Maldi Mass Spectrometry Imaging

Matrix Sublimation Device for MALDI Mass Spectrometry Imaging

2018 ◽  
Vol 91 (1) ◽  
pp. 803-807 ◽  
Author(s):  
Roberto Fernández ◽  
Jone Garate ◽  
Lucia Martín-Saiz ◽  
Igor Galetich ◽  
José A. Fernández
Keyword(s):  
Mass Spectrometry ◽  
Mass Spectrometry Imaging ◽  
Maldi Mass Spectrometry ◽  
Maldi Mass Spectrometry Imaging

scholarly journals Dirigent Protein-Mediated Lignan and Cyanogenic Glucoside Formation in Flax Seed: Integrated Omics and MALDI Mass Spectrometry Imaging

2015 ◽  
Vol 78 (6) ◽  
pp. 1231-1242 ◽  
Author(s):  
Doralyn S. Dalisay ◽  
Kye Won Kim ◽  
Choonseok Lee ◽  
Hong Yang ◽  
Oliver Rübel ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Mass Spectrometry Imaging ◽  
Maldi Mass Spectrometry ◽  
Flax Seed ◽  
Cyanogenic Glucoside ◽  
Dirigent Protein ◽  
Integrated Omics ◽  
Maldi Mass Spectrometry Imaging
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