Analysis of incomplete multivariate data using linear models with structured covariance matrices

1988 ◽  
Vol 7 (1-2) ◽  
pp. 317-324 ◽  
Author(s):  
Mark D. Schluchter
2017 ◽  
Vol 15 (1) ◽  
pp. 126-150 ◽  
Author(s):  
Yongge Tian

Abstract Matrix mathematics provides a powerful tool set for addressing statistical problems, in particular, the theory of matrix ranks and inertias has been developed as effective methodology of simplifying various complicated matrix expressions, and establishing equalities and inequalities occurred in statistical analysis. This paper describes how to establish exact formulas for calculating ranks and inertias of covariances of predictors and estimators of parameter spaces in general linear models (GLMs), and how to use the formulas in statistical analysis of GLMs. We first derive analytical expressions of best linear unbiased predictors/best linear unbiased estimators (BLUPs/BLUEs) of all unknown parameters in the model by solving a constrained quadratic matrix-valued function optimization problem, and present some well-known results on ordinary least-squares predictors/ordinary least-squares estimators (OLSPs/OLSEs). We then establish some fundamental rank and inertia formulas for covariance matrices related to BLUPs/BLUEs and OLSPs/OLSEs, and use the formulas to characterize a variety of equalities and inequalities for covariance matrices of BLUPs/BLUEs and OLSPs/OLSEs. As applications, we use these equalities and inequalities in the comparison of the covariance matrices of BLUPs/BLUEs and OLSPs/OLSEs. The work on the formulations of BLUPs/BLUEs and OLSPs/OLSEs, and their covariance matrices under GLMs provides direct access, as a standard example, to a very simple algebraic treatment of predictors and estimators in linear regression analysis, which leads a deep insight into the linear nature of GLMs and gives an efficient way of summarizing the results.


2016 ◽  
Vol 46 (16) ◽  
pp. 7902-7915 ◽  
Author(s):  
Anna Szczepańska-Álvarez ◽  
Chengcheng Hao ◽  
Yuli Liang ◽  
Dietrich von Rosen

2018 ◽  
Author(s):  
Richard A. Neher

Shared ancestry among individuals results in correlated traits and these dependencies need to be accounted for in probabilistic inference. In strictly asexual populations, the covariances have a particularly simple block-like structure imposed by the phylogenetic tree. Ho and Ane showed how this block-like structure can be exploited to efficiently invert covariance matrices and fit linear models on trees in linear time. In this short note, I use these methods to estimate evolutionary rates and to find the root of the tree that optimizes the time-divergence relationship. The algorithm is implemented in TreeTime and can be used to estimate evolutionary rates and their confidence intervals with computational cost scaling linearly in the number of tips.


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