scholarly journals Multiple imputation of missing covariates for the Cox proportional hazards cure model

2016 ◽  
Vol 35 (26) ◽  
pp. 4701-4717 ◽  
Author(s):  
Lauren J. Beesley ◽  
Jonathan W. Bartlett ◽  
Gregory T. Wolf ◽  
Jeremy M. G. Taylor

Biometrics ◽  
2000 ◽  
Vol 56 (1) ◽  
pp. 227-236 ◽  
Author(s):  
Judy P. Sy ◽  
Jeremy M. G. Taylor




2013 ◽  
Vol 33 (4) ◽  
pp. 650-661 ◽  
Author(s):  
Lili Zhao ◽  
Dai Feng ◽  
Emily L. Bellile ◽  
Jeremy M. G. Taylor


2020 ◽  
pp. 096228022095911
Author(s):  
Bing Wang ◽  
Jialiang Li ◽  
Xiaoguang Wang

The mixture cure model has been widely applied to survival data in which a fraction of the observations never experience the event of interest, despite long-term follow-up. In this paper, we study the Cox proportional hazards mixture cure model where the covariate effects on the distribution of uncured subjects’ failure time may jump when a covariate exceeds a change point. The nonparametric maximum likelihood estimation is used to obtain the semiparametric estimates. We employ a two-step computational procedure involving the Expectation-Maximization algorithm to implement the estimation. The consistency, convergence rate and asymptotic distributions of the estimators are carefully established under technical conditions and we show that the change point estimator is n consistency. The m out of n bootstrap and the Louis algorithm are used to obtain the standard errors of the estimated change point and other regression parameter estimates, respectively. We also contribute a test procedure to check the existence of the change point. The finite sample performance of the proposed method is demonstrated via simulation studies and real data examples.



2001 ◽  
Vol 33 (12-13) ◽  
pp. 1237-1251 ◽  
Author(s):  
J.P. Sy ◽  
J.M.G. Taylor


Biostatistics ◽  
2014 ◽  
Vol 15 (3) ◽  
pp. 540-554 ◽  
Author(s):  
Y. Wu ◽  
Y. Lin ◽  
S.-E. Lu ◽  
C.-S. Li ◽  
W. J. Shih


2014 ◽  
Vol 33 (27) ◽  
pp. 4681-4694 ◽  
Author(s):  
Dan Jackson ◽  
Ian R. White ◽  
Shaun Seaman ◽  
Hannah Evans ◽  
Kathy Baisley ◽  
...  


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