A joint model for multivariate longitudinal and survival data to discover the conversion to Alzheimer's disease

2021 ◽  
Author(s):  
Kai Kang ◽  
Deng Pan ◽  
Xinyuan Song
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Survival Data ◽  
Joint Model ◽  
Longitudinal And Survival Data

scholarly journals Dynamic predictions in Bayesian functional joint models for longitudinal and time-to-event data: An application to Alzheimer’s disease

2017 ◽  
Vol 28 (2) ◽  
pp. 327-342 ◽  
Author(s):  
Kan Li ◽  
Sheng Luo
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Survival Data ◽  
Functional Data ◽  
Joint Modeling ◽  
Joint Model ◽  
Repeated Measurements ◽  
Joint Models ◽  
Modeling Framework ◽  
Dynamic Prediction

In the study of Alzheimer’s disease, researchers often collect repeated measurements of clinical variables, event history, and functional data. If the health measurements deteriorate rapidly, patients may reach a level of cognitive impairment and are diagnosed as having dementia. An accurate prediction of the time to dementia based on the information collected is helpful for physicians to monitor patients’ disease progression and to make early informed medical decisions. In this article, we first propose a functional joint model to account for functional predictors in both longitudinal and survival submodels in the joint modeling framework. We then develop a Bayesian approach for parameter estimation and a dynamic prediction framework for predicting the subjects’ future outcome trajectories and risk of dementia, based on their scalar and functional measurements. The proposed Bayesian functional joint model provides a flexible framework to incorporate many features both in joint modeling of longitudinal and survival data and in functional data analysis. Our proposed model is evaluated by a simulation study and is applied to the motivating Alzheimer’s Disease Neuroimaging Initiative study.

scholarly journals A new joint model for longitudinal and survival data with a cure fraction

2004 ◽  
Vol 91 (1) ◽  
pp. 18-34 ◽  
Author(s):  
Ming-Hui Chen ◽  
Joseph G Ibrahim ◽  
Debajyoti Sinha
Keyword(s):  
Survival Data ◽  
Joint Model ◽  
Cure Fraction ◽  
Longitudinal And Survival Data

scholarly journals A joint model for mixed and truncated longitudinal data and survival data, with application to HIV vaccine studies

Biostatistics ◽  
2017 ◽  
Vol 19 (3) ◽  
pp. 374-390 ◽  
Author(s):  
Tingting Yu ◽  
Lang Wu ◽  
Peter B Gilbert
Keyword(s):  
Longitudinal Data ◽  
Survival Data ◽  
Joint Model ◽  
Hiv Vaccine ◽  
Likelihood Inference ◽  
Likelihood Method ◽  
Parameter Estimates ◽  
Computationally Efficient ◽  
Approximate Likelihood ◽  
Longitudinal And Survival Data

SUMMARY In HIV vaccine studies, a major research objective is to identify immune response biomarkers measured longitudinally that may be associated with risk of HIV infection. This objective can be assessed via joint modeling of longitudinal and survival data. Joint models for HIV vaccine data are complicated by the following issues: (i) left truncations of some longitudinal data due to lower limits of quantification; (ii) mixed types of longitudinal variables; (iii) measurement errors and missing values in longitudinal measurements; (iv) computational challenges associated with likelihood inference. In this article, we propose a joint model of complex longitudinal and survival data and a computationally efficient method for approximate likelihood inference to address the foregoing issues simultaneously. In particular, our model does not make unverifiable distributional assumptions for truncated values, which is different from methods commonly used in the literature. The parameters are estimated based on the h-likelihood method, which is computationally efficient and offers approximate likelihood inference. Moreover, we propose a new approach to estimate the standard errors of the h-likelihood based parameter estimates by using an adaptive Gauss–Hermite method. Simulation studies show that our methods perform well and are computationally efficient. A comprehensive data analysis is also presented.

scholarly journals PRM24 - A JOINT MODEL OF COGNITIVE DECLINE AND TIME TO DIAGNOSIS TO IMPROVE PREDICTIONS OF THE RISK OF DEVELOPING ALZHEIMER’S DISEASE

2018 ◽  
Vol 21 ◽  
pp. S359-S360
Author(s):  
H Karcher ◽  
V Risson ◽  
G Lestini ◽  
N Coello ◽  
L Qi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Decline ◽  
Joint Model ◽  
Time To Diagnosis

scholarly journals A joint model for multiple dynamic processes and clinical endpoints: Application to Alzheimer's disease

2019 ◽  
Vol 38 (23) ◽  
pp. 4702-4717 ◽  
Author(s):  
Cécile Proust‐Lima ◽  
Viviane Philipps ◽  
Jean‐François Dartigues
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Joint Model ◽  
Dynamic Processes ◽  
Clinical Endpoints

scholarly journals Complete Case versus Inverse Probability Weighting Methods of Fitting Incomplete Longitudinal and Survival Data Joint Models

2019 ◽  
pp. 1-10
Author(s):  
D. O. Nyaboga ◽  
A. Mwangi ◽  
D. Lusweti
Keyword(s):  
Missing Data ◽  
Survival Data ◽  
Joint Model ◽  
Information Criteria ◽  
Joint Models ◽  
Full Data ◽  
Complete Case ◽  
Inverse Probability ◽  
Longitudinal And Survival Data ◽  
The Impact

Missing data is a common problem in real word studies especially clinical studies. However, most people working with such data, often drop missing cases from individuals with incomplete observations that occur when patients do not complete the treatment or miss their scheduled visits. This may lead to misleading results and ultimately affect the decision of whether an intervention is good or bad for the patients under treatment. The comparison of Complete Case (CC) and Inverse Probability Weights (IPW) techniques of handling missing data in various models has been addressed, however little has been done to compare these methods when applied to joint models of longitudinal and time to event data. Therefore, this paper seeks to investigate the impact of assuming CC analysis on clinical data with missing cases, comparing it with IPW method when fitting joint models of longitudinal and survival data setting full data model as the baseline model. This paper made use of randomized aids clinical trial data. The model with Deviance Information Criteria (DIC) close to that of full data joint model is considered the best. From the results, joint models from full data, CC and IPW had DIC of 10603.94, 8410.33 and 10600.95 respectively. The joint model obtained from IPW data had a DIC too close to that of full data joint model as compared to model from CC data.

scholarly journals Functional joint model for longitudinal and time-to-event data: an application to Alzheimer's disease

2017 ◽  
Vol 36 (22) ◽  
pp. 3560-3572 ◽  
Author(s):  
Kan Li ◽  
Sheng Luo
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Joint Model ◽  
Event Data ◽  
Time To Event ◽  
Time To Event Data
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