scholarly journals Intravenous Bone Marrow Mononuclear Cells for Acute Ischemic Stroke: Safety, Feasibility, and Effect Size from a Phase I Clinical Trial

Stem Cells ◽  
2019 ◽  
Vol 37 (11) ◽  
pp. 1481-1491 ◽  
Author(s):  
Farhaan S. Vahidy ◽  
Muhammad E. Haque ◽  
Mohammad H. Rahbar ◽  
Hongjian Zhu ◽  
Paul Rowan ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Bone Marrow ◽  
Ischemic Stroke ◽  
Phase I ◽  
Acute Ischemic Stroke ◽  
Effect Size ◽  
Mononuclear Cells ◽  
Phase I Clinical Trial ◽  
Bone Marrow Mononuclear Cells

scholarly journals Autologous Bone Marrow Mononuclear Cells Enhance Recovery after Acute Ischemic Stroke in Young and Middle-Aged Rats

2009 ◽  
Vol 30 (1) ◽  
pp. 140-149 ◽  
Author(s):  
Miranda Brenneman ◽  
Sushil Sharma ◽  
Matthew Harting ◽  
Roger Strong ◽  
Charles S Cox ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Ischemic Stroke ◽  
Carotid Artery ◽  
Acute Ischemic Stroke ◽  
Mononuclear Cells ◽  
Infarct Volume ◽  
Autologous Bone Marrow ◽  
Needle Insertion ◽  
Bone Marrow Mononuclear Cells ◽  
Autologous Bone

We investigated intra-arterially administered autologous bone marrow mononuclear cells (MNCs) in rats with acute ischemic stroke. Long Evans rats (2 to 3 months or 12 months old) underwent tandem reversible common carotid artery (CCA)/middle cerebral artery (MCA) occlusion (CCAo/MCAo) for 3 h and then 24 h later underwent tibial bone marrow harvest. Ten million or 4 million cells were re-injected by an intra-carotid infusion. Control animals underwent marrow needle insertion and then saline injection into the carotid artery. Animals were assessed on a battery of neurological tests. MNCs in the ischemic brain were tracked using Q-dot nanocrystal labeling. Infarct volume and cytokines in the ischemia-affected brain were analyzed. Cell-treated animals in the younger and older groups showed improvement from 7 to 30 days after stroke compared with vehicle-treated animals. MNCs significantly reduced infarct volume compared with saline. There was a significant reduction in tumor necrosis factor-α, interleukin-1α (IL-1α), IL-β, IL-6, and a significant increase in IL-10 in injured brains harvested from the cell-treated groups compared with saline controls. Labeled MNCs were found in the peri-infarcted area at 1 h and exponentially decreased over the ensuing week after injection. Autologous bone marrow MNCs can be safely harvested from rodents after stroke, migrate to the peri-infarct area, enhance recovery, and modulate the post-ischemic inflammatory response.

Phase I Clinical Trial of Autologous Bone Marrow Mononuclear Cells for Pediatric Severe Traumatic Brain Injury

Neurosurgery ◽  
2009 ◽  
Vol 65 (2) ◽  
pp. 412-412
Author(s):  
Charles S. Cox ◽  
James E. Baumgartner ◽  
Laura Worth ◽  
Matthew T. Harting ◽  
Linda Ewing-Cobbs ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Traumatic Brain Injury ◽  
Bone Marrow ◽  
Brain Injury ◽  
Phase I ◽  
Severe Traumatic Brain Injury ◽  
Mononuclear Cells ◽  
Autologous Bone Marrow ◽  
Bone Marrow Mononuclear Cells ◽  
Autologous Bone

Intra-Arterial Infusion of Autologous Bone Marrow Mononuclear Cells in Patients with Moderate to Severe Middle Cerebral Artery Acute Ischemic Stroke

2012 ◽  
Vol 21 (1_suppl) ◽  
pp. 13-21 ◽  
Author(s):  
Maurício A. G. Friedrich ◽  
Maurer P. Martins ◽  
Mariana D. Araújo ◽  
Charles Klamt ◽  
Leonardo Vedolin ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Ischemic Stroke ◽  
Middle Cerebral Artery ◽  
Acute Ischemic Stroke ◽  
Cerebral Artery ◽  
Mononuclear Cells ◽  
Autologous Bone Marrow ◽  
Bone Marrow Mononuclear Cells ◽  
Arterial Infusion ◽  
Autologous Bone

scholarly journals Intra-Arterial Delivery Is Not Superior to Intravenous Delivery of Autologous Bone Marrow Mononuclear Cells in Acute Ischemic Stroke

Stroke ◽  
2013 ◽  
Vol 44 (12) ◽  
pp. 3463-3472 ◽  
Author(s):  
Bing Yang ◽  
Elton Migliati ◽  
Kaushik Parsha ◽  
Krystal Schaar ◽  
XiaoPei Xi ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Mononuclear Cells ◽  
Autologous Bone Marrow ◽  
Bone Marrow Mononuclear Cells ◽  
Autologous Bone

scholarly journals Ischemic Stroke May Activate Bone Marrow Mononuclear Cells to Enhance Recovery After Stroke

2012 ◽  
Vol 21 (18) ◽  
pp. 3332-3340 ◽  
Author(s):  
Bing Yang ◽  
XiaoPei Xi ◽  
Jaroslaw Aronowski ◽  
Sean I. Savitz
Keyword(s):  
Bone Marrow ◽  
Ischemic Stroke ◽  
Mononuclear Cells ◽  
Bone Marrow Mononuclear Cells
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