scholarly journals First-trimester contingent screening for trisomy 21 by biomarkers and maternal blood cell-free DNA testing

2013 ◽  
Vol 42 (1) ◽  
pp. 41-50 ◽  
Author(s):  
K. H. Nicolaides ◽  
D. Wright ◽  
L. C. Poon ◽  
A. Syngelaki ◽  
M. M. Gil
Keyword(s):  
Blood Cell ◽  
Trisomy 21 ◽  
First Trimester ◽  
Maternal Blood ◽  
Dna Testing ◽  
Cell Free Dna ◽  
Free Dna

First-Trimester Contingent Screening for Trisomy 21 by Fetal Nuchal Translucency and Maternal Serum Biomarkers and Maternal Blood Cell-Free DNA Testing

2018 ◽  
Vol 5 (3) ◽  
pp. 139-143
Author(s):  
Sarang Younesi ◽  
Shahram Savad ◽  
Soudeh Ghafouri-Fard ◽  
Mohammad Mahdi Taheri-Amin ◽  
Pourandokht Saadati ◽  
...  
Keyword(s):  
Blood Cell ◽  
Trisomy 21 ◽  
First Trimester ◽  
Nuchal Translucency ◽  
Maternal Blood ◽  
Maternal Serum ◽  
Serum Biomarkers ◽  
Dna Testing ◽  
Cell Free Dna ◽  
Free Dna

First-Trimester Contingent Screening for Trisomies 21, 18, and 13 by Biomarkers and Maternal Blood Cell-Free DNA Testing

2014 ◽  
Vol 69 (9) ◽  
pp. 529-531
Author(s):  
K.H. Nicolaides ◽  
A. Syngelaki ◽  
L.C. Poon ◽  
M.M. Gil ◽  
D. Wright
Keyword(s):  
Blood Cell ◽  
First Trimester ◽  
Maternal Blood ◽  
Dna Testing ◽  
Cell Free Dna ◽  
Free Dna

First-Trimester Contingent Screening for Trisomies 21, 18 and 13 by Biomarkers and Maternal Blood Cell-Free DNA Testing

2013 ◽  
Vol 35 (3) ◽  
pp. 185-192 ◽  
Author(s):  
K.H. Nicolaides ◽  
A. Syngelaki ◽  
L.C. Poon ◽  
M.M. Gil ◽  
D. Wright
Keyword(s):  
Blood Cell ◽  
First Trimester ◽  
Maternal Blood ◽  
Dna Testing ◽  
Cell Free Dna ◽  
Free Dna

scholarly journals Cell-free DNA testing in the maternal blood in high-risk pregnancies after first-trimester combined screening

2016 ◽  
Vol 36 (3) ◽  
pp. 232-236 ◽  
Author(s):  
Nicola Persico ◽  
Simona Boito ◽  
Benedetta Ischia ◽  
Adalgisa Cordisco ◽  
Valentina De Robertis ◽  
...  
Keyword(s):  
High Risk ◽  
First Trimester ◽  
Maternal Blood ◽  
Dna Testing ◽  
Cell Free Dna ◽  
Free Dna

scholarly journals Implementation of maternal blood cell-free DNA testing in early screening for aneuploidies

2013 ◽  
Vol 42 (1) ◽  
pp. 34-40 ◽  
Author(s):  
M. M. Gil ◽  
M. S. Quezada ◽  
B. Bregant ◽  
M. Ferraro ◽  
K. H. Nicolaides
Keyword(s):  
Blood Cell ◽  
Maternal Blood ◽  
Dna Testing ◽  
Early Screening ◽  
Cell Free Dna ◽  
Free Dna

scholarly journals Implementation of Maternal Blood Cell Free DNA Testing in Early Screening for Aneuploidies

2019 ◽  
Vol 1 (1) ◽  
pp. 2-6
Author(s):  
María del Mar Gil ◽  
Kypros H. Nicolaides
Keyword(s):  
Blood Cell ◽  
Maternal Blood ◽  
Dna Testing ◽  
Early Screening ◽  
Cell Free Dna ◽  
Free Dna

scholarly journals Prospective first-trimester screening for trisomies by cell-free DNA testing of maternal blood in twin pregnancy

2016 ◽  
Vol 47 (6) ◽  
pp. 705-711 ◽  
Author(s):  
L. Sarno ◽  
R. Revello ◽  
E. Hanson ◽  
R. Akolekar ◽  
K. H. Nicolaides
Keyword(s):  
Twin Pregnancy ◽  
First Trimester ◽  
Maternal Blood ◽  
First Trimester Screening ◽  
Dna Testing ◽  
Cell Free Dna ◽  
Free Dna ◽  
Trimester Screening

Cell-Free DNA Screening for Fetal Aneuploidy

2021 ◽  
pp. 115-120
Author(s):  
Ashley N. Battarbee ◽  
Neeta L. Vora
Keyword(s):  
Trisomy 21 ◽  
Dna Analysis ◽  
Chromosomal Abnormalities ◽  
Area Under The Curve ◽  
First Trimester ◽  
Outcome Data ◽  
Cell Free Dna ◽  
High Risk Women ◽  
Free Dna ◽  
Trimester Screening

In a prospective, multicenter blinded study at 35 international centers, the Noninvasive Examination of Trisomy (NEXT) study evaluated the performance of cell-free DNA screening for fetal trisomy compared to standard first trimester screening with nuchal translucency and serum analytes in a routine prenatal population. Among the 15,841 women who had standard screening and cell-free DNA analysis with neonatal outcome data, there were 68 chromosomal abnormalities (1 in 236). Of these, 38 were Trisomy 21 (1 in 417). Cell-free DNA analysis had a higher area under the curve (AUC) for trisomy 21, compared to standard screening (0.999 vs. 0.958, p = 0.001). Cell-free DNA analysis also had greater sensitivity, specificity, and positive predictive value compared to standard screening for trisomy 21, 18, and 13. While cell-free DNA analysis cannot detect all chromosome abnormalities, it performed better than standard screening for detection of trisomies 21, 18, and 13 in a routine population including low- and high-risk women.

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