OC11.08: Syndromic craniofacial dysmorphic feature assessment
            in utero
            : potential for a novel imaging methodology with reconstructed 3D fetal MRI models

Incidence of prune belly syndrome (PBS) has remained stable for several decades; advances have been made in prenatal diagnosis with the aid of advanced US and magnetic resonance technology. Use of fetal MRI as an adjunct to US, especially in the setting of oligohydramnios, anhydramnios, and maternal obesity, makes additional imaging methods potentially beneficial. MRI is currently accepted as a valuable technique for fetal anomalies assessment. Addition of three- and four-dimensional US has improved specificity to the traditional two-dimensional imaging. The following discusses the in utero assessment, neonatal and childhood evaluation, and management of PBS. This review contains 5 figures, 2 tables, and 48 references. Key Words: Eagle-Barrett, fast-scanning MRI, fetal ultrasonography, in utero hydronephrosis, prune belly syndrome, triad syndrome, vesicoamniotic shunt,pediatric renal insufficiency

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Abnormalities of the penis in utero – hypospadias on fetal MRI

Journal of Perinatal Medicine ◽

10.1515/jpm.2011.042 ◽

2011 ◽

Vol 39 (4) ◽

Cited By ~ 7

Author(s):

Stefan F. Nemec ◽

Gregor Kasprian ◽

Peter C. Brugger ◽

Dieter Bettelheim ◽

Ursula Nemec ◽

...

Keyword(s):

Fetal Mri ◽

In Utero

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Automatic fetal brain extraction from 2D in utero fetal MRI slices using deep neural network

Neurocomputing ◽

10.1016/j.neucom.2019.10.032 ◽

2020 ◽

Vol 378 ◽

pp. 335-349 ◽

Cited By ~ 5

Author(s):

Jinpeng Li ◽

Yishan Luo ◽

Lin Shi ◽

Xin Zhang ◽

Ming Li ◽

...

Keyword(s):

Neural Network ◽

Deep Neural Network ◽

Fetal Brain ◽

Fetal Mri ◽

In Utero ◽

Brain Extraction

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Severity of Fetal Brain Abnormalities in Congenital Heart Disease in Relation to the Main Expected Pattern of in utero Brain Blood Supply

Fetal Diagnosis and Therapy ◽

10.1159/000439527 ◽

2015 ◽

Vol 39 (4) ◽

pp. 269-278 ◽

Cited By ~ 28

Author(s):

Narcís Masoller ◽

Magda Sanz-Cortés ◽

Fàtima Crispi ◽

Olga Gómez ◽

Mar Bennasar ◽

...

Keyword(s):

Congenital Heart Disease ◽

Heart Disease ◽

Blood Supply ◽

Congenital Heart ◽

Cortical Development ◽

Fetal Brain ◽

Fetal Mri ◽

In Utero ◽

Class A ◽

Severe Reduction

Objectives: We evaluated the hypothesis that in fetuses with congenital heart disease (CHD) there is a correlation between the expected pattern of in utero brain blood supply and the severity of neurodevelopmental impairment. Methods: A total of 58 fetuses with CHD and 58 controls underwent a Doppler ultrasound and fetal MRI at 36-38 weeks. Fetuses with CHD were divided into two functional classes: class A with an expected severe reduction in oxygenated brain blood supply (left outflow tract obstruction and transposition of great vessels) and class B with theoretically near-normal or mildly impaired oxygenated brain blood supply (other CHD). Head biometry and cerebroplacental Doppler were assessed by ultrasound, and brain volumetry, cortical development and metabolism by MRI. Results: Both class A and B CHD fetuses had significant differences in head biometry, brain perfusion, cortical development and brain metabolism compared with controls. However, there was a significant linear tendency for head biometry, cerebral Doppler, volumes, cortical sulcation and metabolic ratios across the three clinical groups, with signs of more severe brain alterations in type A CHD fetuses. Conclusions: All fetuses with CHD showed significant brain developmental changes, but differences were more pronounced in CHD associated with an expected severe reduction in oxygenated blood supply to the brain.

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Alterations in Ultrastructure of Skeletal Muscle From Newborn Guinea Pigs Following in Utero Exposure to Ethanol

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100120126 ◽

1985 ◽

Vol 43 ◽

pp. 686-687

Author(s):

C. Uphoff ◽

C. Nyquist-Battie ◽

T.B. Cole

Keyword(s):

Skeletal Muscle ◽

Guinea Pigs ◽

Muscle Development ◽

In Utero ◽

Ethanol Exposure ◽

Prenatally Exposed ◽

Chronic Alcoholic ◽

Test Kit ◽

Food And Water Intake ◽

Post Intubation

Ultrastructural alterations of skeletal muscle have been observed in adult chronic alcoholic patients. However, no such study has been performed on individuals prenatally exposed to ethanol. In order to determine if ethanol exposure in utero in the latter stages of muscle development was deleterious, skeletal muscle was obtained from newborn guinea pigs treated in the following manner. Six Hartly strain pregnant guinea pigs were randomly assigned to either the ethanol or the pair-intubated groups. Twice daily the 3 ethanol-treated animals were intubated with Ensure (Ross Laboratories) liquid diet containing 30% ethanol (6g/Kg pre-pregnant body weight per day) from day 35 of gestation until parturition at day 70±1 day. Serum ethanol levels were determined at 1 hour post-intubation by the Sigma alcohol test kit. For pair-intubation the Ensure diet contained sucrose substituted isocalorically for ethanol. Both food and water intake were monitored.

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