scholarly journals Targeted Disruption of Hoxd9 and Hoxd10 Alters Locomotor Behavior, Vertebral Identity, and Peripheral Nervous System Development

1999 ◽  
Vol 216 (2) ◽  
pp. 595-610 ◽  
Author(s):  
Cecile C. de la Cruz ◽  
Andre Der-Avakian ◽  
Demetri D. Spyropoulos ◽  
David D. Tieu ◽  
Ellen M. Carpenter
Keyword(s):  
Nervous System ◽  
Peripheral Nervous System ◽  
System Development ◽  
Locomotor Behavior ◽  
Nervous System Development ◽  
Targeted Disruption

scholarly journals Functional dissection of the Pax6 paired domain: Roles in neural tube patterning and peripheral nervous system development

2016 ◽  
Vol 413 (1) ◽  
pp. 86-103 ◽  
Author(s):  
Rosa-Eva Huettl ◽  
Simone Eckstein ◽  
Tessa Stahl ◽  
Stefania Petricca ◽  
Jovica Ninkovic ◽  
...  
Keyword(s):  
Nervous System ◽  
Peripheral Nervous System ◽  
Neural Tube ◽  
System Development ◽  
Nervous System Development ◽  
Paired Domain

scholarly journals Rescue of the Cardiac Defect in ErbB2 Mutant Mice Reveals Essential Roles of ErbB2 in Peripheral Nervous System Development

Neuron ◽  
1999 ◽  
Vol 23 (2) ◽  
pp. 273-283 ◽  
Author(s):  
Jacqueline K Morris ◽  
Weichun Lin ◽  
Chris Hauser ◽  
Yelena Marchuk ◽  
Damon Getman ◽  
...  
Keyword(s):  
Nervous System ◽  
Peripheral Nervous System ◽  
System Development ◽  
Nervous System Development ◽  
Mutant Mice ◽  
Cardiac Defect

scholarly journals Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development

2007 ◽  
Vol 177 (6) ◽  
pp. 1051-1061 ◽  
Author(s):  
Yves Benninger ◽  
Tina Thurnherr ◽  
Jorge A. Pereira ◽  
Sven Krause ◽  
Xunwei Wu ◽  
...  
Keyword(s):  
Nervous System ◽  
Schwann Cell ◽  
Peripheral Nervous System ◽  
Schwann Cells ◽  
Rho Gtpases ◽  
Cell Biology ◽  
System Development ◽  
Nervous System Development ◽  
Conditional Gene Targeting ◽  
Radial Sorting

During peripheral nervous system (PNS) myelination, Schwann cells must interpret extracellular cues to sense their environment and regulate their intrinsic developmental program accordingly. The pathways and mechanisms involved in this process are only partially understood. We use tissue-specific conditional gene targeting to show that members of the Rho GTPases, cdc42 and rac1, have different and essential roles in axon sorting by Schwann cells. Our results indicate that although cdc42 is required for normal Schwann cell proliferation, rac1 regulates Schwann cell process extension and stabilization, allowing efficient radial sorting of axon bundles.

scholarly journals Extracellular microRNAs as messengers in the central and peripheral nervous system

2017 ◽  
Vol 1 (4) ◽  
Author(s):  
Hannah Scott
Keyword(s):  
Nervous System ◽  
Peripheral Nervous System ◽  
Intercellular Communication ◽  
System Development ◽  
Transcriptional Regulators ◽  
Body Fluids ◽  
Nervous System Development ◽  
Target Cells ◽  
Specific Target ◽  
Active Processes

MicroRNAs are small post-transcriptional regulators that play an important role in nervous system development, function and disease. More recently, microRNAs have been detected extracellularly and circulating in blood and other body fluids, where they are protected from degradation by encapsulation in vesicles, such as exosomes, or by association with proteins. These microRNAs are thought to be released from cells selectively through active processes and taken up by specific target cells within the same or in remote tissues where they are able to exert their repressive function. These characteristics make extracellular microRNAs ideal candidates for intercellular communication over short and long distances. This review aims to explore the potential mechanisms underlying microRNA communication within the nervous system and between the nervous system and other tissues. The suggested roles of extracellular microRNAs in the healthy and the diseased nervous system will be reviewed.

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