The Drosophila homolog of the immunoglobulin recombination signal-binding protein regulates peripheral nervous system development

Cell ◽  
1992 ◽  
Vol 69 (7) ◽  
pp. 1191-1197 ◽  
Author(s):  
Takahisa Furukawa ◽  
Shingo Maruyama ◽  
Masashi Kawaichi ◽  
Tasuku Honjo
Keyword(s):  
Nervous System ◽  
Peripheral Nervous System ◽  
System Development ◽  
Binding Protein ◽  
Nervous System Development ◽  
Recombination Signal ◽  
Drosophila Homolog

scholarly journals Functional dissection of the Pax6 paired domain: Roles in neural tube patterning and peripheral nervous system development

2016 ◽  
Vol 413 (1) ◽  
pp. 86-103 ◽  
Author(s):  
Rosa-Eva Huettl ◽  
Simone Eckstein ◽  
Tessa Stahl ◽  
Stefania Petricca ◽  
Jovica Ninkovic ◽  
...  
Keyword(s):  
Nervous System ◽  
Peripheral Nervous System ◽  
Neural Tube ◽  
System Development ◽  
Nervous System Development ◽  
Paired Domain

scholarly journals Rescue of the Cardiac Defect in ErbB2 Mutant Mice Reveals Essential Roles of ErbB2 in Peripheral Nervous System Development

Neuron ◽  
1999 ◽  
Vol 23 (2) ◽  
pp. 273-283 ◽  
Author(s):  
Jacqueline K Morris ◽  
Weichun Lin ◽  
Chris Hauser ◽  
Yelena Marchuk ◽  
Damon Getman ◽  
...  
Keyword(s):  
Nervous System ◽  
Peripheral Nervous System ◽  
System Development ◽  
Nervous System Development ◽  
Mutant Mice ◽  
Cardiac Defect

scholarly journals Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development

2007 ◽  
Vol 177 (6) ◽  
pp. 1051-1061 ◽  
Author(s):  
Yves Benninger ◽  
Tina Thurnherr ◽  
Jorge A. Pereira ◽  
Sven Krause ◽  
Xunwei Wu ◽  
...  
Keyword(s):  
Nervous System ◽  
Schwann Cell ◽  
Peripheral Nervous System ◽  
Schwann Cells ◽  
Rho Gtpases ◽  
Cell Biology ◽  
System Development ◽  
Nervous System Development ◽  
Conditional Gene Targeting ◽  
Radial Sorting

During peripheral nervous system (PNS) myelination, Schwann cells must interpret extracellular cues to sense their environment and regulate their intrinsic developmental program accordingly. The pathways and mechanisms involved in this process are only partially understood. We use tissue-specific conditional gene targeting to show that members of the Rho GTPases, cdc42 and rac1, have different and essential roles in axon sorting by Schwann cells. Our results indicate that although cdc42 is required for normal Schwann cell proliferation, rac1 regulates Schwann cell process extension and stabilization, allowing efficient radial sorting of axon bundles.

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