Loss and Subsequent Recovery of Local Cerebral Glucose Use in Visual Targets after Controlled Optic Nerve Crush in Adult Rats

1996 ◽  
Vol 139 (1) ◽  
pp. 17-24 ◽  
Author(s):  
U. Schmitt ◽  
R. Cross ◽  
T.L. Pazdernik ◽  
B.A. Sabel
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Crush ◽  
Adult Rats ◽  
Nerve Crush ◽  
Subsequent Recovery ◽  
Visual Targets

Y-P30 confers neuroprotection after optic nerve crush in adult rats

Neuroreport ◽  
2011 ◽  
Vol 22 (11) ◽  
pp. 544-547 ◽  
Author(s):  
Tamar Macharadze ◽  
Peter Landgraf ◽  
Hans-Christian Pape ◽  
Petra Wahle ◽  
Michael R. Kreutz
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Crush ◽  
Adult Rats ◽  
Nerve Crush

Upregulation of Gem relates to retinal ganglion cells apoptosis after optic nerve crush in adult rats

2014 ◽  
Vol 45 (5) ◽  
pp. 565-571 ◽  
Author(s):  
Fan Xu ◽  
Hui Huang ◽  
Yu Wu ◽  
Lu Lu ◽  
Li Jiang ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Optic Nerve Crush ◽  
Retinal Ganglion ◽  
Adult Rats ◽  
Nerve Crush

Viability of retinal ganglion cells after optic nerve crush in adult rats

1984 ◽  
Vol 13 (3) ◽  
pp. 449-465 ◽  
Author(s):  
Louis J. Misantone ◽  
Mark Gershenbaum ◽  
Marion Murray
Keyword(s):  
Optic Nerve ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Optic Nerve Crush ◽  
Retinal Ganglion ◽  
Adult Rats ◽  
Nerve Crush

scholarly journals Cholinergic Potentiation of Restoration of Visual Function after Optic Nerve Damage in Rats

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Mira Chamoun ◽  
Elena G. Sergeeva ◽  
Petra Henrich-Noack ◽  
Shaobo Jia ◽  
Lisa Grigartzik ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Optic Nerve ◽  
Evoked Potentials ◽  
Visual Function ◽  
Cortical Plasticity ◽  
Brightness Discrimination ◽  
Acetylcholinesterase Inhibitor ◽  
Optic Nerve Crush ◽  
Adult Rats ◽  
Nerve Crush

Enhancing cortical plasticity and brain connectivity may improve residual vision following a visual impairment. Since acetylcholine plays an important role in attention and neuronal plasticity, we explored whether potentiation of the cholinergic transmission has an effect on the visual function restoration. To this end, we evaluated for 4 weeks the effect of the acetylcholinesterase inhibitor donepezil on brightness discrimination, visually evoked potentials, and visual cortex reactivity after a bilateral and partial optic nerve crush in adult rats. Donepezil administration enhanced brightness discrimination capacity after optic nerve crush compared to nontreated animals. The visually evoked activation of the primary visual cortex was not restored, as measured by evoked potentials, but the cortical neuronal activity measured by thallium autometallography was not significantly affected four weeks after the optic nerve crush. Altogether, the results suggest a role of the cholinergic system in postlesion cortical plasticity. This finding agrees with the view that restoration of visual function may involve mechanisms beyond the area of primary damage and opens a new perspective for improving visual rehabilitation in humans.

The Expression Changes of Myelin and Lymphocyte Protein (MAL) Following Optic Nerve Crush in Adult Rats Retinal Ganglion Cells

2014 ◽  
Vol 54 (4) ◽  
pp. 614-621 ◽  
Author(s):  
Yongsheng Huang ◽  
Yue Xu ◽  
Qiaochu Cheng ◽  
Shanshan Yu ◽  
Yi Gao ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Optic Nerve Crush ◽  
Retinal Ganglion ◽  
Adult Rats ◽  
Nerve Crush

Different functional susceptibilities of mouse retinal ganglion cell subtypes to optic nerve crush injury

2017 ◽  
Vol 162 ◽  
pp. 97-103 ◽  
Author(s):  
Zhen Puyang ◽  
Hai-Qing Gong ◽  
Shi-Gang He ◽  
John B. Troy ◽  
Xiaorong Liu ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Crush Injury ◽  
Optic Nerve Crush ◽  
Retinal Ganglion ◽  
Nerve Crush ◽  
Nerve Crush Injury
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