Deficits in Striatal Dopamine D2 Receptors and Energy Metabolism Detected by in Vivo MicroPET Imaging in a Rat Model of Huntington's Disease

2000 ◽  
Vol 166 (2) ◽  
pp. 287-297 ◽  
Author(s):  
Dalia M. Araujo ◽  
Simon R. Cherry ◽  
Keith J. Tatsukawa ◽  
Tatsushi Toyokuni ◽  
Harley I. Kornblum
Keyword(s):  
Energy Metabolism ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Rat Model ◽  
D2 Receptors ◽  
Dopamine D2 Receptors ◽  
Striatal Dopamine ◽  
Micropet Imaging ◽  
Dopamine D2

scholarly journals Dopamine D2 Receptor Imaging with SPECT: Studies in Different Neuropsychiatric Disorders

1991 ◽  
Vol 11 (2) ◽  
pp. 220-228 ◽  
Author(s):  
T. Brücke ◽  
I. Podreka ◽  
P. Angelberger ◽  
S. Wenger ◽  
A. Topitz ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Specific Binding ◽  
D2 Receptors ◽  
Dopamine D2 Receptors ◽  
Racemic Mixture ◽  
Curvilinear Relationship ◽  
Receptor Blockade ◽  
Neuroleptic Treatment ◽  
Dopamine D2

The purpose of the present study is to visualize and quantify dopamine D2 receptors in the living human brain using an 123I-labeled ligand and the single photon emission computerized tomography (SPECT) technique. S-(–)-Iodobenzamide [ S-(–)-IBZM] has been shown to be a highly selective ligand with high affinity for D2 receptors in experimental studies. Five millicuries (185 MBq) of 123I-labeled S-(–)-IBZM was administered intravenously to 12 control subjects, 22 parkinsonian patients under L-Dopa therapy, 12 parkinsonian patients without L-Dopa, 10 unmedicated patients with Huntington's disease, and 12 patients under different neuroleptics. Data collection with a rotating double-head scintillation camera started 1 h after injection and lasted for 50 min. In a semiquantitative approach, a ratio was calculated between mean counts per pixel in the striatum and a region in the lateral frontal cortex, which was 1.74 ± 0.10 in the control group. A marked reduction of this ratio was found in patients with Huntington's disease (1.38 ± 0.12; p = 0.0001), no significant changes in untreated parkinsonian patients (1.67 ± 0.14), but a reduction in L-Dopa-treated cases (1.59 ± 0.13; p = 0.0014). A curvilinear relationship was found between total daily dose of neuroleptics and the reduction of this ratio. Estimated receptor blockade under full neuroleptic treatment was 75–80%. S-(–)-IBZM binding was reduced with increasing age (p < 0.01). Specific binding was reduced markedly when the racemic mixture of IBZM was used, and no specific binding was seen with the R-(+)-isomer, demonstrating the stereoselectivity of IBZM binding. The results show that dopamine D2 receptors can be clearly visualized with high resolution using the SPECT technique and S-(–)-IBZM as a ligand. A semiquantitative approach can give estimates for receptor blockade or receptor density. This method is of clinical value for the diagnosis of degenerative neurological disorders such as Huntington's disease and for the monitoring of neuroleptic treatment.

scholarly journals 371 STRIATAL DOPAMINE D2 RECEPTORS ATTENUATE NEUROPATHIC HYPERSENSITIVITY IN THE RAT

2007 ◽  
Vol 11 (S1) ◽  
pp. S165-S165
Author(s):  
O.B. Ansah ◽  
H. Leite-Almeida ◽  
H. Wei ◽  
A. Pertovaara
Keyword(s):  
D2 Receptors ◽  
Dopamine D2 Receptors ◽  
Striatal Dopamine ◽  
Dopamine D2

scholarly journals Effect of loss of the locus coeruleus noradrenergic projections by DSP-4 treatment on striatal dopamine D2 receptors

2003 ◽  
Vol 85 ◽  
pp. 18-18 ◽  
Author(s):  
A. Terasmaa ◽  
M. Eller ◽  
K. Fuxe ◽  
J. Harro ◽  
A. Rinken
Keyword(s):  
Locus Coeruleus ◽  
D2 Receptors ◽  
Dopamine D2 Receptors ◽  
Striatal Dopamine ◽  
Dopamine D2

In vivo imaging of adenovirus-mediated over-expression of dopamine D2 receptors in rat striatum by positron emission tomography

Neuroreport ◽  
2000 ◽  
Vol 11 (4) ◽  
pp. 743-748 ◽  
Author(s):  
Osamu Ogawa ◽  
Hiroyuki Umegaki ◽  
Kiichi Ishiwata ◽  
Yukako Asai ◽  
Hiroyuki Ikari ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
In Vivo Imaging ◽  
D2 Receptors ◽  
Dopamine D2 Receptors ◽  
Emission Tomography ◽  
Rat Striatum ◽  
Over Expression ◽  
Dopamine D2 ◽  
Positron Emission

scholarly journals A Mechanism Linking Two Known Vulnerability Factors for Alcohol Abuse: Heightened Alcohol Stimulation and Low Striatal Dopamine D2 Receptors

Cell Reports ◽  
2019 ◽  
Vol 29 (5) ◽  
pp. 1147-1163.e5 ◽  
Author(s):  
Miriam E. Bocarsly ◽  
Daniel da Silva e Silva ◽  
Vanessa Kolb ◽  
Kathryn D. Luderman ◽  
Sannidhi Shashikiran ◽  
...  
Keyword(s):  
Alcohol Abuse ◽  
D2 Receptors ◽  
Dopamine D2 Receptors ◽  
Striatal Dopamine ◽  
Vulnerability Factors ◽  
Dopamine D2

scholarly journals Striatal dopamine D2 receptors attenuate neuropathic hypersensitivity in the rat

2007 ◽  
Vol 205 (2) ◽  
pp. 536-546 ◽  
Author(s):  
Osei B. Ansah ◽  
Hugo Leite-Almeida ◽  
Hong Wei ◽  
Antti Pertovaara
Keyword(s):  
D2 Receptors ◽  
Dopamine D2 Receptors ◽  
Striatal Dopamine ◽  
Dopamine D2

In vitro and in vivo binding of dopamine D2-receptors with 123I iodobenzamide in rat and human brain

1990 ◽  
Vol 183 (4) ◽  
pp. 1414
Author(s):  
N.P.L.G. Verhoeff ◽  
M. Bobeldijk ◽  
E.A. van Royen ◽  
M.G.P. Feenstra ◽  
G.J. Boer ◽  
...  
Keyword(s):  
Human Brain ◽  
D2 Receptors ◽  
Dopamine D2 Receptors ◽  
In Vivo Binding ◽  
Dopamine D2

Striatal dopamine D2 receptors, metabolism, and volume in preclinical Huntington disease

Neurology ◽  
2005 ◽  
Vol 65 (6) ◽  
pp. 941-943 ◽  
Author(s):  
J.C.H. van Oostrom ◽  
R. P. Maguire ◽  
C. C. Verschuuren-Bemelmans ◽  
L. Veenma-van der Duin ◽  
J. Pruim ◽  
...  
Keyword(s):  
Huntington Disease ◽  
D2 Receptors ◽  
Dopamine D2 Receptors ◽  
Striatal Dopamine ◽  
Dopamine D2
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