Atrial Natriuretic Peptide Suppresses Osmotically Stimulated Plasma Arginine Vasotocin Levels in the Pekin Duck

1994 ◽  
Vol 93 (1) ◽  
pp. 122-127 ◽  
Author(s):  
David A. Gray
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Arginine Vasotocin ◽  
Pekin Duck ◽  
Plasma Arginine ◽  
Atrial Natriuretic

Role of endogenous atrial natriuretic peptide in volume expansion diuresis and natriuresis of the Pekin duck

1994 ◽  
Vol 140 (1) ◽  
pp. 85-90 ◽  
Author(s):  
D A Gray
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Volume Expansion ◽  
Polyclonal Antibodies ◽  
Physiological Role ◽  
Arginine Vasotocin ◽  
Pekin Duck ◽  
Plasma Parameters ◽  
Atrial Natriuretic

Abstract Polyclonal antibodies raised in a rabbit against avian atrial natriuretic peptide (ANP) were shown to reduce circulating endogenous ANP levels in Pekin ducks by more than 90%, and were subsequently used to investigate the role of this peptide in volume expansion diuresis and natriuresis. Conscious birds, undergoing a steady-state diuresis and natriuresis maintained by an i.v. infusion of hypotonic saline at a rate of 0·7 ml/min, responded to ANP antiserum (anti-ANP) with an immediate 30% reduction in urine flow rate and sodium excretion which lasted for about 30 min. Plasma arginine vasotocin levels were not changed by anti-ANP whereas circulating angiotensin II concentrations increased immediately following the administration of anti-ANP. Serum from non-immunized normal rabbits produced no changes in the renal and plasma parameters monitored. The results show that the high circulating levels of endogenous ANP associated with volume expansion promote renal salt and fluid excretion and thus have a major physiological role in avian volume homeostasis. Journal of Endocrinology (1994) 140, 85–90

Plasma Arginine-Vasopressin Levels During Infusion of Synthetic Atrial Natriuretic Peptide on Different Sodium Intakes in Man

1986 ◽  
Vol 4 (5) ◽  
pp. 623-629 ◽  
Author(s):  
Markus P. Gn??dinger ◽  
Peter Weidmann ◽  
Wolfgang Rascher ◽  
Rudolf E. Lang ◽  
Beat Hellm??ller ◽  
...  
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Arginine Vasopressin ◽  
Plasma Arginine ◽  
Atrial Natriuretic

Atrial natriuretic peptide inhibits osmolality-induced arginine vasopressin release in man

1988 ◽  
Vol 75 (1) ◽  
pp. 35-39 ◽  
Author(s):  
M. J. Allen ◽  
V. T. Y. Ang ◽  
E. D. Bennett ◽  
J. S. Jenkins
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Arginine Vasopressin ◽  
Plasma Osmolality ◽  
Random Order ◽  
Vasopressin Release ◽  
Plasma Arginine ◽  
Placebo Infusion ◽  
Atrial Natriuretic

1. Eight normal volunteers were infused with 5% saline (5 g of NaCl/100 ml) at a rate of 0.06 ml min−1 kg−1 for 120 min to increase plasma osmolality and plasma arginine vasopressin. Human atrial natriuretic peptide (α-hANP; 100 μg) or placebo was given in random order in a double-bind cross-over design for the last 20 min of the saline infusion. 2. Compared with the placebo infusion, atrial natriuretic peptide (ANP) produced a 43% greater sodium excretion and a 34% greater urinary volume in the subsequent hour. 3. Mean plasma immunoreactive ANP did not increase in response to changes in osmolality and rose to a peak of 118 pg/ml during the α-hANP infusion. α-hANP produced significant suppression of mean plasma arginine vasopressin over the 60 min after the infusions. 4. We conclude that ANP is not released in response to increased osmolality in vivo, and that it inhibits osmolality-induced arginine vasopressin release in man.

Cardiovascular effects of arginine vasotocin, atrial natriuretic peptide, and epinephrine in freshwater eels

1995 ◽  
Vol 268 (5) ◽  
pp. R1273-R1280 ◽  
Author(s):  
G. Y. Oudit ◽  
D. G. Butler
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Cardiovascular Effects ◽  
Aortic Pressure ◽  
Arginine Vasotocin ◽  
Systemic Resistance ◽  
Pressor Responses ◽  
Freshwater Eels ◽  
Positive Chronotropic Effect ◽  
Atrial Natriuretic

The effects of 150 ng/kg iv injections of arginine vasotocin (AVT), eel atrial natriuretic peptide (ANP), and epinephrine (Epi) on the cardiovascular dynamics of resting freshwater eels, Anguilla rostrata were studied. Injection of AVT into the caudal vein significantly increased cardiac output (CO) from 15.3 to 23.6 ml.min-1.kg-1 primarily by increasing stroke volume. Mean dorsal aortic pressure (PDA) also increased. Estimated branchial shunting (2.54 ml.min-1.kg-1) was elevated by 130% because of an increased proportion of CO, indicating a vasoconstriction of the branchial arterioarterial pathway. In contrast, Epi reduced the fraction of CO perfusing the arteriovenous pathway. Epi also produced a positive chronotropic effect, increased CO and systemic vasoconstriction, resulting in a vasopressor response. These changes occurred earlier than those of AVT and ANP. Pressor responses triggered by AVT and Epi preceded the increases in CO. Injections of 150 and 200 ng/kg ANP caused a reduction in PDA due to a decrease in CO (and SV) but failed to modulate systemic resistance. The change in CO was the primary contributor to the pressor (and depressor) responses elicited by the three hormones.

Plasma Arginine Vasopressin Levels During Atrial Natriuretic Peptide Infusion in the Young and Elderly

1993 ◽  
Vol 22 (suppl 2) ◽  
pp. P14-P14
Author(s):  
E. Mulkerrin ◽  
A. Brain ◽  
D. Hampton ◽  
D. Sykes ◽  
M.D. Penney ◽  
...  
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Arginine Vasopressin ◽  
Plasma Arginine ◽  
Atrial Natriuretic

Endogenous plasma atrial natriuretic peptide and the control of salt gland function in the Pekin duck

1997 ◽  
Vol 273 (3) ◽  
pp. R1080-R1085 ◽  
Author(s):  
D. A. Gray ◽  
C. Downing ◽  
N. Sayed
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Salt Gland ◽  
Gland Secretion ◽  
Pekin Duck ◽  
Salt Glands ◽  
Experimental Conditions ◽  
Salt Gland Secretion ◽  
Gland Function ◽  
Atrial Natriuretic

Polyclonal antibodies raised in a rabbit against avian atrial natriuretic peptide (ANP) were used to investigate the role of endogenous plasma ANP in the control of salt gland function of conscious, saltwater-adapted Pekin ducks. Salt gland secretion was initiated and maintained either by a hypervolemic (290 mosmol/kg NaCl i.v. at 2 ml/min) or hyperosmotic (1,000 mosmol/kg NaCl i.v. at 0.4 ml/min) stimulus. Both experimental conditions caused significant elevations in endogenous plasma ANP concentrations. At steady states of secretion driven by hypervolemia, the administration of ANP antiserum (anti-ANP), which reduced plasma ANP concentrations by 90%, caused an immediate 30% reduction in fluid secretion rate and sodium excretion that lasted for 20-30 min. The activity of salt glands driven by hyperosmolality was not changed by anti-ANP. The results show that the high circulating concentrations of endogenous ANP associated with conditions of sustained volume expansion promote salt gland secretion.

Passive heat exposure leads to delayed increase in plasma levels of atrial natriuretic peptide in humans

1991 ◽  
Vol 71 (2) ◽  
pp. 716-720 ◽  
Author(s):  
J. Leppaluoto ◽  
O. Arjamaa ◽  
O. Vuolteenaho ◽  
H. Ruskoaho
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Atrial Natriuretic Peptide ◽  
Systolic Blood Pressure ◽  
Natriuretic Peptide ◽  
Heat Exposure ◽  
Plasma Renin ◽  
Evaporative Water ◽  
Plasma Arginine ◽  
Atrial Natriuretic

The effects of passive heat exposure on atrial natriuretic peptide (ANP) were studied in six healthy men staying in a Finnish sauna at +92 degrees C for 20 min. Their rectal temperature increased by 0.4 degrees C, and evaporative water loss was 0.92 +/- 0.14 (SD) kg. Heart rate and systolic blood pressure increased significantly during the 20-min exposure. Serum osmolality and plasma arginine vasopressin levels increased during the exposure, then declined, and increased significantly again at 90–120 min. Plasma renin activity and aldosterone increased by two- to fourfold in 20 min. Plasma ANP levels rose from 13 +/- 7 to 39 +/- 15 ng/l at 60 min and to 41 +/- 13 ng/l at 120 min (P less than 0.01 for both). We conclude that transient increases in heart rate and systolic blood pressure or changes in blood volume as inferred from the weight loss do not contribute to the increased plasma ANP levels observed after the heat exposure. Instead, increased secretions of pressor hormones could explain the elevated plasma ANP levels observed after the thermal stress.

Atrial natriuretic peptide inhibits postural release of renin and vasopressin in humans

1988 ◽  
Vol 255 (3) ◽  
pp. R368-R372 ◽  
Author(s):  
T. D. Williams ◽  
K. P. Walsh ◽  
S. L. Lightman ◽  
R. Sutton
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Plasma Volume ◽  
Plasma Renin ◽  
The Other ◽  
Plasma Norepinephrine ◽  
Head Up Tilt ◽  
Plasma Arginine ◽  
Rate Infusion ◽  
Atrial Natriuretic

The effects of infusions of atrial natriuretic peptide (ANP) on the hormonal and hemodynamic responses to head-up tilt were investigated in six healthy adults. Head-up tilt at 45 degrees for 2 h during placebo saline infusion caused a 7% fall in blood volume accompanied by increases in plasma renin activity (PRA) and plasma arginine vasopressin (AVP) of 112 and 175%, respectively. Head-up tilt was repeated during an infusion of ANP producing a four- to sixfold increase in plasma ANP concentrations. This resulted in an 18% fall in plasma volume, yet despite this greater fall in plasma volume, PRA did not change. Two subjects experienced vasovagal symptoms toward the end of the ANP infusions accompanied by large increases in plasma AVP. In the other four subjects, plasma AVP remained unchanged during ANP infusions. Both procedures resulted in similar increases in plasma norepinephrine levels and in heart rate. Infusion of ANP prevents the posturally stimulated release of renin and AVP.

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