Isolation and Characterization of Insulin-like Growth Factor-I from Rainbow Trout, Oncorhynchus mykiss

1995 ◽  
Vol 99 (2) ◽  
pp. 221-229 ◽  
Author(s):  
Shunsuke Moriyama ◽  
Walton W. Dickhoff ◽  
Erika M. Plisetskaya
Keyword(s):  
Rainbow Trout ◽  
Growth Factor ◽  
Oncorhynchus Mykiss ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Rainbow Trout Oncorhynchus Mykiss ◽  
Isolation And Characterization ◽  
Growth Factor I

Osmoregulatory actions of insulin-like growth factor-I in rainbow trout (Oncorhynchus mykiss)

1991 ◽  
Vol 130 (1) ◽  
pp. 87-92 ◽  
Author(s):  
S. D. McCormick ◽  
T. Sakamoto ◽  
S. Hasegawa ◽  
T. Hirano
Keyword(s):  
Rainbow Trout ◽  
Growth Factor ◽  
Oncorhynchus Mykiss ◽  
Bovine Insulin ◽  
Insulin Like Growth Factor ◽  
Plasma Osmolarity ◽  
Seawater Adaptation ◽  
Factor I ◽  
Igf I ◽  
Growth Factor I

ABSTRACT The ability of insulin-like growth factor-I (IGF-I), insulin and GH to promote hypoosmoregulatory ability was examined in juvenile rainbow trout (Oncorhynchus mykiss). Following adaptation to 12 parts per thousand (p.p.t.) seawater for 5 days, fish were given a single injection of hormone or vehicle, then exposed to 29 p.p.t. for 24 h and examined for changes in plasma osmolarity, ions and glucose. Ovine GH (oGH; 0·2 μg/g) significantly improved the ability of rainbow trout to maintain plasma osmolarity and sodium levels following transfer to 29 p.p.t. seawater. Recombinant bovine IGF-I (0·01, 0·05 and 0·2 μg/g) also improved the hypoosmoregulatory ability of trout; the effect being dose-dependent and greater than that of oGH. Bovine insulin (0·01, 0·05 and 0·2 μg/g) had no statistically significant effect on plasma ions. The results indicate that IGF-I is a potential mediator of the action of GH in seawater adaptation of salmonids. Journal of Endocrinology (1991) 130, 87–92

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