Dose–Time Response in Mouse Skin Tumor Induction by 7,12-Dimethylbenz[a]anthracene and 12-O-Tetradecanoyl-phorbol-13-acetate

1996 ◽  
Vol 23 (1) ◽  
pp. 44-48 ◽  
Author(s):  
Werner K. Lutz ◽  
Peter E. Beland ◽  
Regula Candrian ◽  
Tamas Fekete ◽  
Wolfgang H. Fischer
Keyword(s):  
Mouse Skin ◽  
Skin Tumor ◽  
Time Response ◽  
Tumor Induction ◽  
Dose Time

Epidermal ornithine decarboxylase induction and mouse skin tumor promotion by quinones

1990 ◽  
Vol 11 (10) ◽  
pp. 1795-1801 ◽  
Author(s):  
Terrence J. Monks ◽  
Susan E. Walker ◽  
Linda M. Flynn ◽  
Claudio J. Conti ◽  
John DiGiovanni
Keyword(s):  
Ornithine Decarboxylase ◽  
Mouse Skin ◽  
Tumor Promotion ◽  
Skin Tumor

Dose–time response association between occupational asbestos exposure and pleural mesothelioma: authors’ response

2017 ◽  
Vol 75 (2) ◽  
pp. 161-162 ◽  
Author(s):  
Aude Lacourt ◽  
Emilie Leveque ◽  
Marcel Goldberg ◽  
Karen Leffondre
Keyword(s):  
Asbestos Exposure ◽  
Time Response ◽  
Pleural Mesothelioma ◽  
Dose Time

Effects of Acute and Subchronic Exposure of Topically Applied Fullerene Extracts on the Mouse Skin

1993 ◽  
Vol 9 (4) ◽  
pp. 623-630 ◽  
Author(s):  
Mark A. Nelson ◽  
Frederick E. Domann ◽  
G. Tim Bowden ◽  
Stephen B. Hooser ◽  
Quintus Fernando ◽  
...  
Keyword(s):  
Dna Synthesis ◽  
Ornithine Decarboxylase ◽  
Mouse Skin ◽  
Tumor Formation ◽  
Skin Tumor ◽  
Toxic Effects ◽  
Exposure Level ◽  
Decarboxylase Activity ◽  
Ornithine Decarboxylase Activity ◽  
Acute Toxic

The recent discovery that fullerenes (C60) can be produced in macroscopic quantities has sparked much interest in the chemistry of this unusual molecule. Concerns have also arose about the potential carcinogenic effects of this molecule. We have addressed the potential acute and subchronic toxic effects of fullerenes applied in benzene on the mouse skin. The acute toxic effects measured in this study included epidermal DNA synthesis and the induction of ornithine decarboxylase activity in the epidermis. At the topical dose of fullerenes used in these studies (i.e., 200 ug), we found no effect on either DNA synthesis or ornithine decarboxylase activity over a 72 hour time course after treatment. The subchronic effects of the fullerenes as a mouse skin tumor promoter was assessed by repeatedly applying the chemical to the skin after initiation with the polycyclic aromatic hydrocarbon, 7,12-dimethlybenz-anthracene (DMBA). Repeated administration of the fullerenes for up to 24 weeks post-initiation did not result in either benign or malignant skin tumor formation, whereas promotion with the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA) resulted in the formation of benign skin tumors. Our data indicate that fullerenes applied in benzene at a likely industrial exposure level do not cause acute toxic effects on the mouse skin epidermis.

Reversal of food restriction-induced inhibition of mouse skin tumor promotion by adrenalectomy

1992 ◽  
Vol 13 (10) ◽  
pp. 1925-1928 ◽  
Author(s):  
Laura L. Pashko ◽  
Arthur G. Schwartz
Keyword(s):  
Food Restriction ◽  
Mouse Skin ◽  
Tumor Promotion ◽  
Skin Tumor

Methylation of the O6-methylguanine-DNA methyltransferase promoter suppresses expression in mouse skin tumors and varies with the tumor induction protocol

2005 ◽  
Vol 118 (3) ◽  
pp. 527-531 ◽  
Author(s):  
Rana Abdel-Fattah ◽  
Adam Glick ◽  
Ishtiaq Rehman ◽  
Patrick Maiberger ◽  
Henry Hennings
Keyword(s):  
Dna Methyltransferase ◽  
Mouse Skin ◽  
Skin Tumors ◽  
Tumor Induction ◽  
Methylguanine Dna Methyltransferase
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