Nucleotide Sequence Analysis of a 21-kbp Region of the Genome of Human Herpesvirus-6 Containing Homologues of Human Cytomegalovirus Major Immediate-Early and Replication Genes

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Author(s):  
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1995 ◽  
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S. Gummuluru ◽  
D. J. Sherwood ◽  
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C. B. Hall ◽  
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Nabil Abid Ben Salem ◽  
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Salma Feki ◽  
Mahjoub Aouni ◽  
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ABSTRACT We identified a 6-aminoquinolone compound, WC5, that inhibits human cytomegalovirus (HCMV) replication with a selectivity index of ∼500. WC5 also showed activity against drug-resistant HCMV strains. In contrast, it did not significantly affect the replication of human herpesvirus 6 and 8 and was ∼10-fold less active against murine cytomegalovirus. Thus, WC5 may represent a lead for the development of new, potent, and selective anti-HCMV compounds.


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