scholarly journals Hepatitis C Virus Glycoprotein E2 Binding to CD81: The Role of E1E2 Cleavage and Protein Glycosylation in Bioactivity

Virology ◽  
2000 ◽  
Vol 273 (1) ◽  
pp. 60-66 ◽  
Author(s):  
Christine Chan-Fook ◽  
Wen-Rong Jiang ◽  
Berwyn E. Clarke ◽  
Nicole Zitzmann ◽  
Catherine Maidens ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Protein Glycosylation ◽  
Virus Glycoprotein ◽  
Glycoprotein E2

scholarly journals Role of Conserved Cysteine Residues in Hepatitis C Virus Glycoprotein E2 Folding and Function

2012 ◽  
Vol 86 (7) ◽  
pp. 3961-3974 ◽  
Author(s):  
K. McCaffrey ◽  
I. Boo ◽  
K. Tewierek ◽  
M. L. Edmunds ◽  
P. Poumbourios ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Cysteine Residues ◽  
Virus Glycoprotein ◽  
Glycoprotein E2 ◽  
And Function

scholarly journals The core domain of hepatitis C virus glycoprotein E2 generates potent cross-neutralizing antibodies in guinea pigs

Hepatology ◽  
2017 ◽  
Vol 65 (4) ◽  
pp. 1117-1131 ◽  
Author(s):  
Patricia T. Vietheer ◽  
Irene Boo ◽  
Jun Gu ◽  
Kathleen McCaffrey ◽  
Stirling Edwards ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Guinea Pigs ◽  
Neutralizing Antibodies ◽  
Core Domain ◽  
Virus Glycoprotein ◽  
The Core ◽  
Glycoprotein E2

scholarly journals Interplay between Basic Residues of Hepatitis C Virus Glycoprotein E2 with Viral Receptors, Neutralizing Antibodies and Lipoproteins

PLoS ONE ◽  
2012 ◽  
Vol 7 (12) ◽  
pp. e52651 ◽  
Author(s):  
George Koutsoudakis ◽  
Jakub Dragun ◽  
Sofia Pérez-del-Pulgar ◽  
Mairene Coto-Llerena ◽  
Laura Mensa ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Neutralizing Antibodies ◽  
Virus Glycoprotein ◽  
Glycoprotein E2 ◽  
Viral Receptors

scholarly journals DC-SIGN and L-SIGN Are High Affinity Binding Receptors for Hepatitis C Virus Glycoprotein E2

2003 ◽  
Vol 278 (22) ◽  
pp. 20358-20366 ◽  
Author(s):  
Pierre-Yves Lozach ◽  
Hugues Lortat-Jacob ◽  
Agnès De Lacroix De Lavalette ◽  
Isabelle Staropoli ◽  
Steven Foung ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Affinity Binding ◽  
High Affinity Binding ◽  
Virus Glycoprotein ◽  
High Affinity ◽  
Glycoprotein E2

849 INTERPLAY BETWEEN BASIC RESIDUES OF HEPATITIS C VIRUS GLYCOPROTEIN E2 WITH LIPOPROTEINS, VIRAL RECEPTORS AND NEUTRALIZING ANTIBODIES

2012 ◽  
Vol 56 ◽  
pp. S331
Author(s):  
G. Koutsoudakis ◽  
J. Dragun ◽  
S. Perez del Pulgar ◽  
M. Coto-Llerena ◽  
L. Mensa ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Neutralizing Antibodies ◽  
Virus Glycoprotein ◽  
Glycoprotein E2 ◽  
Viral Receptors

scholarly journals Expression and Characterization of a Minimal Hepatitis C Virus Glycoprotein E2 Core Domain That Retains CD81 Binding

2007 ◽  
Vol 81 (17) ◽  
pp. 9584-9590 ◽  
Author(s):  
Kathleen McCaffrey ◽  
Irene Boo ◽  
Pantelis Poumbourios ◽  
Heidi E. Drummer
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Variable Region ◽  
Sequence Comparisons ◽  
Variable Regions ◽  
Core Domain ◽  
Virus Glycoprotein ◽  
Glycoprotein E2 ◽  
Cd81 Binding

ABSTRACT The hepatitis C virus glycoprotein E2 receptor-binding domain is encompassed by amino acids 384 to 661 (E2661) and contains two hypervariable sequences, HVR1 and HVR2. E2 sequence comparisons revealed a third variable region, located between residues 570 and 580, that varies widely between genotypes, designated here as igVR, the intergenotypic variable region. A secreted E2661 glycoprotein with simultaneous deletions of the three variable sequences retained its ability to bind CD81 and conformation-dependent monoclonal antibodies (MAbs) and displayed enhanced binding to a neutralizing MAb directed to E2 immunogenic domain B. Our data provide insights into the E2 structure by suggesting that the three variable regions reside outside a conserved E2 core.

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