Inflammatory Bowel Disease: Pathophysiology and Current Therapeutic Approaches

2017 ◽  
pp. 115-146 ◽  
Author(s):  
Bincy P. Abraham ◽  
Tasneem Ahmed ◽  
Tauseef Ali
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Therapeutic Approaches ◽  
Inflammatory Bowel

scholarly journals The gut virome in inflammatory bowel disease pathogenesis: From metagenomics to novel therapeutic approaches

2019 ◽  
Vol 7 (8) ◽  
pp. 999-1007 ◽  
Author(s):  
Federica Ungaro ◽  
Luca Massimino ◽  
Silvia D’Alessio ◽  
Silvio Danese
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Therapeutic Approaches ◽  
Disease Pathogenesis ◽  
Inflammatory Bowel ◽  
Novel Therapeutic

Nutritional deficiencies in inflammatory bowel disease: Therapeutic approaches

2013 ◽  
Vol 32 (6) ◽  
pp. 904-910 ◽  
Author(s):  
Sara Massironi ◽  
Roberta Elisa Rossi ◽  
Federica Alessandra Cavalcoli ◽  
Serena Della Valle ◽  
Mirella Fraquelli ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Nutritional Deficiencies ◽  
Therapeutic Approaches ◽  
Inflammatory Bowel

scholarly journals New Insights on CD8+ T Cells in Inflammatory Bowel Disease and Therapeutic Approaches

2021 ◽  
Vol 12 ◽  
Author(s):  
Rosaely Casalegno Garduño ◽  
Jan Däbritz
Keyword(s):  
Inflammatory Bowel Disease ◽  
T Cells ◽  
Cd8 T Cells ◽  
Bowel Disease ◽  
Positive Outcome ◽  
T Cell Subsets ◽  
Therapeutic Approaches ◽  
Therapeutic Value ◽  
Inflammatory Bowel

CD8+ T cells are involved in the pathogenesis of inflammatory bowel disease (IBD), a complex multifactorial chronic disease. Here, we present an overview of the current research with the controversial findings of CD8+ T cell subsets and discuss some possible perspectives on their therapeutic value in IBD. Studies on the role of CD8+ T cells in IBD have contradictory outcomes, which might be related to the heterogeneity of the cells. Recent data suggest that cytotoxic CD8+ T cells (Tc1) and interleukin (IL) 17-producing CD8+ (Tc17) cells contribute to the pathogenesis of IBD. Moreover, subsets of regulatory CD8+ T cells are abundant at sites of inflammation and can exhibit pro-inflammatory features. Some subsets of tissue resident memory CD8+ T cells (Trm) might be immunosuppressant, whereas others might be pro-inflammatory. Lastly, exhausted T cells might indicate a positive outcome for patients. The function and plasticity of different subsets of CD8+ T cells in health and IBD remain to be further investigated in a challenging field due to the limited availability of mucosal samples and adequate controls.

The corticotropin-releasing factor system in inflammatory bowel disease: Prospects for new therapeutic approaches

2009 ◽  
Vol 14 (13-14) ◽  
pp. 713-720 ◽  
Author(s):  
Konstantinos A. Paschos ◽  
George Kolios ◽  
Ekaterini Chatzaki
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Corticotropin Releasing Factor ◽  
Therapeutic Approaches ◽  
New Therapeutic Approaches ◽  
Inflammatory Bowel ◽  
Factor System

Gut microflora: a new target for therapeutic approaches in inflammatory bowel disease

2008 ◽  
Vol 12 (3) ◽  
pp. 301-312 ◽  
Author(s):  
Keiichi Mitsuyama ◽  
Michio Sata
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Gut Microflora ◽  
Therapeutic Approaches ◽  
Inflammatory Bowel

scholarly journals Different therapeutic approaches on quality of life in patients with inflammatory bowel disease

2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Junjie Xu ◽  
Hui Lin ◽  
Xu Feng ◽  
Minyue Tang ◽  
Jun Shen ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Therapeutic Approaches ◽  
Inflammatory Bowel
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