Clinical Development of Histamine H4 Receptor Antagonists

2017 ◽  
pp. 301-320 ◽  
Author(s):  
Robin L. Thurmond ◽  
Jennifer Venable ◽  
Brad Savall ◽  
David La ◽  
Sandra Snook ◽  
...  
Keyword(s):  
Clinical Development ◽  
Receptor Antagonists ◽  
Histamine H4 Receptor ◽  
H4 Receptor

A novel series of histamine H4 receptor antagonists based on the pyrido[3,2-d]pyrimidine scaffold: Comparison of hERG binding and target residence time with PF-3893787

2013 ◽  
Vol 23 (9) ◽  
pp. 2663-2670 ◽  
Author(s):  
Mounir Andaloussi ◽  
Herman D. Lim ◽  
Tiffany van der Meer ◽  
Maarten Sijm ◽  
Chris B.M. Poulie ◽  
...  
Keyword(s):  
Residence Time ◽  
Receptor Antagonists ◽  
Histamine H4 Receptor ◽  
H4 Receptor

Inhibitory effects of histamine H4 receptor antagonists on experimental colitis in the rat

2005 ◽  
Vol 522 (1-3) ◽  
pp. 130-138 ◽  
Author(s):  
Csaba Varga ◽  
Krisztina Horvath ◽  
Aniko Berko ◽  
Robin L. Thurmond ◽  
Paul J. Dunford ◽  
...  
Keyword(s):  
Experimental Colitis ◽  
Inhibitory Effects ◽  
Receptor Antagonists ◽  
Histamine H4 Receptor ◽  
H4 Receptor

Anti-inflammatory and antinociceptive effects of the histamine H4-receptor antagonists in animal models of acute inflammation

2013 ◽  
Vol 65 ◽  
pp. 69-70
Author(s):  
Szczepan Mogilski ◽  
Monika Kubacka ◽  
Małgorzata Więcek ◽  
Katarzyna Kieć-Kononowicz ◽  
Barbara Filipek
Keyword(s):  
Animal Models ◽  
Acute Inflammation ◽  
Receptor Antagonists ◽  
Histamine H4 Receptor ◽  
Antinociceptive Effects ◽  
Anti Inflammatory ◽  
H4 Receptor

Antinociceptive effect of co-administered NMDA and histamine H4 receptor antagonists in a rat model of acute pain

2017 ◽  
Vol 69 (2) ◽  
pp. 222-228 ◽  
Author(s):  
Renata Wolińska ◽  
Anna Leśniak ◽  
Małgorzata Żochowska ◽  
Mariusz Sacharczuk ◽  
Katarzyna Kieć-Kononowicz ◽  
...  
Keyword(s):  
Acute Pain ◽  
Rat Model ◽  
Antinociceptive Effect ◽  
Receptor Antagonists ◽  
Histamine H4 Receptor ◽  
H4 Receptor

Synthesis and structure–activity relationships of indole and benzimidazole piperazines as histamine H4 receptor antagonists

2004 ◽  
Vol 14 (21) ◽  
pp. 5251-5256 ◽  
Author(s):  
Nalan Terzioglu ◽  
Richard M. van Rijn ◽  
Remko A. Bakker ◽  
Iwan J.P. De Esch ◽  
Rob Leurs
Keyword(s):  
Receptor Antagonists ◽  
Histamine H4 Receptor ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
H4 Receptor

Rigidified 2-aminopyrimidines as histamine H4 receptor antagonists: Effects of substitution about the rigidifying ring

2010 ◽  
Vol 20 (6) ◽  
pp. 1900-1904 ◽  
Author(s):  
John R. Koenig ◽  
Huaqing Liu ◽  
Irene Drizin ◽  
David G. Witte ◽  
Tracy L. Carr ◽  
...  
Keyword(s):  
Receptor Antagonists ◽  
Histamine H4 Receptor ◽  
H4 Receptor

Histamine H4 receptor antagonists are superior to traditional antihistamines in the attenuation of experimental pruritus

2007 ◽  
Vol 119 (1) ◽  
pp. 176-183 ◽  
Author(s):  
Paul J. Dunford ◽  
Kacy N. Williams ◽  
Pragnya J. Desai ◽  
Lars Karlsson ◽  
Daniel McQueen ◽  
...  
Keyword(s):  
Receptor Antagonists ◽  
Histamine H4 Receptor ◽  
H4 Receptor

Histamine H4 receptor antagonists for the treatment of inflammatory disorders

2014 ◽  
Vol 19 (8) ◽  
pp. 1222-1225 ◽  
Author(s):  
Wai L. Liu
Keyword(s):  
Receptor Antagonists ◽  
Histamine H4 Receptor ◽  
Inflammatory Disorders ◽  
H4 Receptor

Ligand based design of novel histamine H4 receptor antagonists; fragment optimization and analysis of binding kinetics

2012 ◽  
Vol 22 (1) ◽  
pp. 461-467 ◽  
Author(s):  
Rogier A. Smits ◽  
Herman D. Lim ◽  
Tiffany van der Meer ◽  
Sebastiaan Kuhne ◽  
Karin Bessembinder ◽  
...  
Keyword(s):  
Binding Kinetics ◽  
Receptor Antagonists ◽  
Histamine H4 Receptor ◽  
H4 Receptor
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