Effects of Selective Inhibition of PDE4 by YM976 on Airway Reactivity and Cough in Ovalbumin-Sensitized Guinea Pigs

2016 ◽  
pp. 61-70 ◽  
Author(s):  
J. Mokrý ◽  
A. Urbanová ◽  
I. Medvedová ◽  
M. Kertys ◽  
P. Mikolka ◽  
...  
Keyword(s):  
Guinea Pigs ◽  
Selective Inhibition ◽  
Airway Reactivity

Effects of Selective Inhibition of PDE4 and PDE7 on Airway Reactivity and Cough in Healthy and Ovalbumin-Sensitized Guinea Pigs

2012 ◽  
pp. 57-64 ◽  
Author(s):  
Juraj Mokry ◽  
Marta Joskova ◽  
Daniela Mokra ◽  
Ingrid Christensen ◽  
Gabriela Nosalova
Keyword(s):  
Guinea Pigs ◽  
Selective Inhibition ◽  
Airway Reactivity

Effects of Propranolol and Indomethacin on Muscarinic Airway Reactivity in Unanesthetized Guinea Pigs

1986 ◽  
Vol 181 (4) ◽  
pp. 569-574 ◽  
Author(s):  
J. H. Roum ◽  
C. G. Murlas
Keyword(s):  
Guinea Pigs ◽  
Airway Reactivity

Antagonism of airway reactivity induced by ovalbumin antigen in guinea pigs by 5-amino-4-imidazolecarboxamide riboside

1991 ◽  
Vol 88 (4) ◽  
pp. 604-612 ◽  
Author(s):  
D BERGREN ◽  
R TOWNLEY ◽  
D MARQUARDT ◽  
H GRUBER ◽  
V BERGREN
Keyword(s):  
Guinea Pigs ◽  
Airway Reactivity

Antiarrhythmic ionic mechanism of Guanfu base A—Selective inhibition of late sodium current in isolated ventricular myocytes from guinea pigs

2015 ◽  
Vol 13 (5) ◽  
pp. 361-367 ◽  
Author(s):  
Si-Si JIN ◽  
Qiao GUO ◽  
Jing XU ◽  
Peng YU ◽  
Jing-Han LIU ◽  
...  
Keyword(s):  
Guinea Pigs ◽  
Ventricular Myocytes ◽  
Sodium Current ◽  
Selective Inhibition ◽  
Ionic Mechanism ◽  
Late Sodium Current ◽  
Isolated Ventricular Myocytes

Toluene diisocyanate-induced airway hyperreactivity in guinea pigs depleted of granulocytes

1988 ◽  
Vol 64 (5) ◽  
pp. 1773-1778 ◽  
Author(s):  
W. Cibulas ◽  
S. M. Brooks ◽  
C. G. Murlas ◽  
M. L. Miller ◽  
R. T. McKay
Keyword(s):  
Guinea Pigs ◽  
Bronchial Hyperreactivity ◽  
Airway Hyperreactivity ◽  
Toluene Diisocyanate ◽  
High Concentration ◽  
Airway Reactivity ◽  
Cyclophosphamide Treatment ◽  
Tracheal Tissue ◽  
Unanesthetized Animals ◽  
And Control

The influence of cyclophosphamide-induced granulocyte depletion on toluene diisocyanate (TDI)-related changes in airway reactivity and pathology was assessed in guinea pigs. Twelve cyclophosphamide-treated and 12 control animals comprising each group were studied physiologically before and 2 h after a single 10-min exposure to 3 ppm of TDI. Reactivity was determined in intact unanesthetized animals by measuring specific airway conductance before and during intravenous acetylcholine infusion. After testing, tracheal tissue for light microscopic examination was obtained from three hyperreactive guinea pigs in each exposed group and compared with tissue from treated and control animals (n = 3 each) that had not been TDI exposed. Cyclophosphamide treatment caused substantial decreases in both circulating and airway granulocyte counts. However, the incidence and degree of bronchial hyperreactivity that occurred 2 h post-TDI was similar in the untreated and treated groups. Our results indicate that TDI-induced bronchial hyperreactivity 1) occurs shortly after a brief high concentration exposure and 2) appears independent of circulating or airway granulocyte counts.

Inhaled roflumilast and tadalafil supress airway reactivity and inflammation in ovalbumin-sensitized guinea pigs

2016 ◽  
Author(s):  
Juraj Mokry ◽  
Anna Urbanova ◽  
Martin Kertys ◽  
Ivana Medvedova ◽  
Peter Mikolka ◽  
...  
Keyword(s):  
Guinea Pigs ◽  
Airway Reactivity

Effect of Sodium Hypochlorite on Specific Airway Resistance and Airway Reactivity in Guinea Pigs

1993 ◽  
Vol 5 (2) ◽  
pp. 251-263 ◽  
Author(s):  
Taro Mizutani ◽  
Takahiro Kobayashi ◽  
Hiroshi Naito
Keyword(s):  
Sodium Hypochlorite ◽  
Guinea Pigs ◽  
Airway Resistance ◽  
Airway Reactivity ◽  
Specific Airway Resistance

scholarly journals Selective inhibition of arachidonate 5-lipoxygenase by novel acetohydroxamic acids: effects on bronchial anaphylaxis in anaesthetized guinea-pigs

1988 ◽  
Vol 94 (2) ◽  
pp. 540-546 ◽  
Author(s):  
A.N. Payne ◽  
L.G. Garland ◽  
I.W. Lees ◽  
J.A. Salmon
Keyword(s):  
Guinea Pigs ◽  
Selective Inhibition
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