Synaptic Plasticity in the Pathophysiology and Treatment of Bipolar Disorder

2010 ◽  
pp. 167-185 ◽  
Author(s):  
Jing Du ◽  
Rodrigo Machado-Vieira ◽  
Rushaniya Khairova
Keyword(s):  
Bipolar Disorder ◽  
Synaptic Plasticity

scholarly journals Evidence for reduced long-term potentiation-like visual cortical plasticity in schizophrenia and bipolar disorder

2020 ◽  
Author(s):  
Mathias Valstad ◽  
Daniël Roelfs ◽  
Nora B. Slapø ◽  
Clara M.F. Timpe ◽  
Ahsan Rai ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Synaptic Plasticity ◽  
Symptom Severity ◽  
Cortical Plasticity ◽  
Long Term Potentiation ◽  
Type I ◽  
Term Potentiation ◽  
Spectrum Disorders ◽  
Visual Cortical

AbstractBackgroundSeveral lines of research suggest that impairments in long-term potentiation (LTP)-like synaptic plasticity might be a key pathophysiological mechanism in schizophrenia (SZ) and bipolar disorder type I (BDI) and II (BDII). Using modulations of visually evoked potentials (VEP) of the electroencephalogram, impaired LTP-like visual cortical plasticity has been implicated in patients with BDII, while there has been conflicting evidence in SZ, a lack of research in BDI, and mixed results regarding associations with symptom severity, mood states, and medication.MethodsWe measured the VEP of patients with SZ spectrum disorders (n=31), BDI (n=34), BDII (n=33), and other BD spectrum disorders (n=2), and age-matched healthy control participants (n=200) before and after prolonged visual stimulation.ResultsCompared to healthy controls, modulation of VEP component N1b, but not C1 or P1, was impaired both in patients within the SZ spectrum (χ2=35.1, p=3.1×10−9) and BD spectrum (χ2=7.0, p=8.2×10−3), including BDI (χ2=6.4, p=0.012), but not BDII (χ2=2.2, p=0.14). N1b modulation was also more severely impaired in SZ spectrum than BD spectrum patients (χ2=14.2, p=1.7×10−4). The reduction in N1b modulation was related to PANSS total scores (χ2=10.8, p=1.0×10−3), and nominally to number of psychotic episodes (χ2=4.9, p=0.027). Conclusions. These results suggest that LTP-like plasticity is impaired in SZ and BDI, but not BDII, and related to psychotic symptom severity. Adding to previous genetic, pharmacological, and anatomical evidence, these results implicate aberrant synaptic plasticity as a mechanism underlying SZ and BD.

Navigating Tx of Bipolar Disorder in Pregnancy

Ob Gyn News ◽  
2005 ◽  
Vol 40 (3) ◽  
pp. 11
Author(s):  
DIANA MAHONEY
Keyword(s):  
Bipolar Disorder ◽  
In Pregnancy

Valproate May Help Child With Bipolar Disorder

2005 ◽  
Vol 39 (5) ◽  
pp. 26
Author(s):  
Jeff Evans
Keyword(s):  
Bipolar Disorder

Diagnosis of Bipolar Disorder Usually Takes Several Years

2005 ◽  
Vol 38 (2) ◽  
pp. 19
Author(s):  
SHARON WORCESTER
Keyword(s):  
Bipolar Disorder

Bipolar Disorder

2017 ◽  
Author(s):  
Robert P. Reiser ◽  
Larry W. Thompson ◽  
Sheri L. Johnson ◽  
Trisha Suppes
Keyword(s):  
Bipolar Disorder

Childhood Bipolar Disorder: Documenting a Psychiatric/Cultural Orthodoxy

PsycCRITIQUES ◽  
2006 ◽  
Vol 51 (9) ◽  
Author(s):  
Tracy A. Knight
Keyword(s):  
Bipolar Disorder
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