Gene Therapy in Nonneoplastic Lung Disease

2008 ◽  
pp. 510-523
Author(s):  
Timothy Craig Allen ◽  
Philip T. Cagle
Keyword(s):  
Gene Therapy ◽  
Lung Disease

Gene Therapy for Lung Disease: Hype or Hope?

2000 ◽  
Vol 132 (8) ◽  
pp. 649 ◽  
Author(s):  
Steven M. Albelda ◽  
Rainer Wiewrodt ◽  
Jonathan B. Zuckerman
Keyword(s):  
Gene Therapy ◽  
Lung Disease

scholarly journals Effective lung-targeted RNAi in mice with peptide-based delivery of nucleic acid

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Kaido Kurrikoff ◽  
Krista Freimann ◽  
Kadi-Liis Veiman ◽  
Elin Madli Peets ◽  
Andres Piirsoo ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Nucleic Acid ◽  
Lung Disease ◽  
Lung Tissue ◽  
Lung Inflammation ◽  
Disease Models ◽  
Nucleic Acid Delivery ◽  
Acute Lung Inflammation ◽  
Disease Symptoms ◽  
Targeted Gene Therapy

AbstractWe have previously developed efficient peptide-based nucleic acid delivery vectors PF14 and NF55, where we have shown that these vectors preferentially transfect lung tissue upon systemic administration with the nucleic acid. In the current work, we have explored the utilization and potential of these vectors for the lung-targeted gene therapy. Accordingly, we assessed the efficacy of these peptides in (i) two different lung disease models – acute lung inflammation and asthma in mice and (ii) using two different nucleic acid cargos – siRNA and pDNA encoding shRNA. Using RNAi against cytokine TNFα, we showed efficient anti-inflammatory effects in both disease models and observed decreased disease symptoms. Our results highlight the potential of our transfection vectors for lung gene therapy.

Latest Advances in Gene Therapy in Management of Cystic Fibrosis Lung Disease, Literature Review

2021 ◽  
Vol 12 (1) ◽  
pp. 67-70
Author(s):  
Saad Saeed Alghamdi ◽  
Naif Mohammed Alhamyani ◽  
Hamzah Mohammed Alamri ◽  
Thamer Saad Alzahrani ◽  
Sultan Mousa Daghas ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Gene Therapy ◽  
Literature Review ◽  
Lung Disease ◽  
Cystic Fibrosis Lung ◽  
Cystic Fibrosis Lung Disease

Fetoscopic gene therapy for congenital lung disease

1997 ◽  
Vol 32 (7) ◽  
pp. 964-969 ◽  
Author(s):  
Karl G Sylvester ◽  
Edmund Y Yang ◽  
Darrell L Cass ◽  
Timothy M Crombleholme ◽  
N.Scott Adzick
Keyword(s):  
Gene Therapy ◽  
Lung Disease
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