In Vitro Screening Models to Assess Intestinal Drug Absorption and Metabolism

2007 ◽  
pp. 182-215 ◽  
Author(s):  
Sven Deferme ◽  
Pieter Annaert ◽  
Patrick Augustijns
Keyword(s):  
Drug Absorption ◽  
In Vitro Screening ◽  
Intestinal Drug Absorption

ChemInform Abstract: In vitro Systems for Studying Intestinal Drug Absorption

ChemInform ◽  
2010 ◽  
Vol 26 (31) ◽  
pp. no-no
Author(s):  
K. M. HILLGREN ◽  
A. KATO ◽  
R. T. BORCHARDT
Keyword(s):  
Drug Absorption ◽  
Intestinal Drug Absorption ◽  
In Vitro Systems

scholarly journals In-Depth Characterization of EpiIntestinal Microtissue as a Model for Intestinal Drug Absorption and Metabolism in Human

Pharmaceutics ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 405 ◽  
Author(s):  
Yunhai Cui ◽  
Stephanie Claus ◽  
David Schnell ◽  
Frank Runge ◽  
Caroline MacLean
Keyword(s):  
Drug Absorption ◽  
Oral Absorption ◽  
Human Intestine ◽  
Cancer Resistance ◽  
Holistic Model ◽  
Glycoprotein P ◽  
Intestinal Drug Absorption ◽  
Fraction Absorbed ◽  
Vitro Model

The Caco-2 model is a well-accepted in vitro model for the estimation of fraction absorbed in human intestine. Due to the lack of cytochrome P450 3A4 (CYP3A4) activities, Caco-2 model is not suitable for the investigation of intestinal first-pass metabolism. The purpose of this study is to evaluate a new human intestine model, EpiIntestinal microtissues, as a tool for the prediction of oral absorption and metabolism of drugs in human intestine. The activities of relevant drug transporters and drug metabolizing enzymes, including MDR1 P-glycoprotein (P-gp), breast cancer resistance protein (BCRP), CYP3A4, CYP2J2, UDP-glucuronosyltransferases (UGT), carboxylesterases (CES), etc., were detected in functional assays with selective substrates and inhibitors. Compared to Caco-2, EpiIntestinal microtissues proved to be a more holistic model for the investigation of drug absorption and metabolism in human gastrointestinal tract.

New Methods to Evaluate Intestinal Drug Absorption Mediated by Oligopeptide Transporter from In vitro Study using Caco-2 Cells

2002 ◽  
Vol 17 (5) ◽  
pp. 408-415 ◽  
Author(s):  
Shinji Yamashita ◽  
Emiko Hattori ◽  
Aiko Shimada ◽  
Yoriko Endoh ◽  
Yukako Yamazaki ◽  
...  
Keyword(s):  
Drug Absorption ◽  
In Vitro Study ◽  
Vitro Study ◽  
Oligopeptide Transporter ◽  
New Methods ◽  
Intestinal Drug Absorption

In vitro systems for studying intestinal drug absorption

1995 ◽  
Vol 15 (2) ◽  
pp. 83-109 ◽  
Author(s):  
Kathleen M. Hillgren ◽  
Akira Kato ◽  
Ronald T. Borchardt
Keyword(s):  
Drug Absorption ◽  
Intestinal Drug Absorption ◽  
In Vitro Systems

scholarly journals Biopredictive in vitro testing methods to assess intestinal drug absorption from supersaturating dosage forms

2020 ◽  
Vol 56 ◽  
pp. 101275 ◽  
Author(s):  
Bart Hens ◽  
Makoto Kataoka ◽  
Keisuke Ueda ◽  
Ping Gao ◽  
Yasuhiro Tsume ◽  
...  
Keyword(s):  
Drug Absorption ◽  
Dosage Forms ◽  
In Vitro Testing ◽  
Testing Methods ◽  
Intestinal Drug Absorption

In vitro studies of intestinal drug absorption

1991 ◽  
Vol 42 (12) ◽  
pp. 2259-2264 ◽  
Author(s):  
Caroline J. Alcorn ◽  
Robert J. Simpson ◽  
David Leahy ◽  
Timothy J. Peters
Keyword(s):  
Drug Absorption ◽  
In Vitro Studies ◽  
Intestinal Drug Absorption
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