Optical Methods for the Measurement and Manipulation of Cytosolic Calcium Signals in Neutrophils

2019 ◽  
pp. 191-205 ◽  
Author(s):  
Maurice B. Hallett ◽  
Rhiannon E. Roberts ◽  
Sharon Dewitt
Keyword(s):  
Cytosolic Calcium ◽  
Optical Methods ◽  
Calcium Signals

scholarly journals Sodium/Calcium Exchangers Selectively Regulate Calcium Signaling in Mouse Taste Receptor Cells

2010 ◽  
Vol 104 (1) ◽  
pp. 529-538 ◽  
Author(s):  
Steven A. Szebenyi ◽  
Agnieszka I. Laskowski ◽  
Kathryn F. Medler
Keyword(s):  
Calcium Release ◽  
Calcium Influx ◽  
Taste Receptor ◽  
Physiological Role ◽  
Cytosolic Calcium ◽  
Calcium Signals ◽  
Sodium Calcium ◽  
Signaling Mechanisms ◽  
Taste Cells ◽  
Mouse Taste

Taste cells use multiple signaling mechanisms to generate appropriate cellular responses to discrete taste stimuli. Some taste stimuli activate G protein coupled receptors (GPCRs) that cause calcium release from intracellular stores while other stimuli depolarize taste cells to cause calcium influx through voltage-gated calcium channels (VGCCs). While the signaling mechanisms that initiate calcium signals have been described in taste cells, the calcium clearance mechanisms (CCMs) that contribute to the termination of these signals have not been identified. In this study, we used calcium imaging to define the role of sodium-calcium exchangers (NCXs) in the termination of evoked calcium responses. We found that NCXs regulate the calcium signals that rely on calcium influx at the plasma membrane but do not significantly contribute to the calcium signals that depend on calcium release from internal stores. Our data indicate that this selective regulation of calcium signals by NCXs is due primarily to their location in the cell rather than to the differences in cytosolic calcium loads. This is the first report to define the physiological role for any of the CCMs utilized by taste cells to regulate their evoked calcium responses.

scholarly journals Paclitaxel Affects Cytosolic Calcium Signals by Opening the Mitochondrial Permeability Transition Pore

2001 ◽  
Vol 277 (8) ◽  
pp. 6504-6510 ◽  
Author(s):  
Jackie F. Kidd ◽  
Mary F. Pilkington ◽  
Michael J. Schell ◽  
Kevin E. Fogarty ◽  
Jeremy N. Skepper ◽  
...  
Keyword(s):  
Mitochondrial Permeability Transition Pore ◽  
Mitochondrial Permeability Transition ◽  
Permeability Transition Pore ◽  
Permeability Transition ◽  
Cytosolic Calcium ◽  
Calcium Signals ◽  
Mitochondrial Permeability

scholarly journals Multiple cytosolic calcium signals and membrane electrical events evoked in single arginine vasopressin-stimulated corticotrophs.

1993 ◽  
Vol 268 (30) ◽  
pp. 22313-22321
Author(s):  
J.B. Corcuff ◽  
N.C. Guérineau ◽  
P Mariot ◽  
B.T. Lussier ◽  
P Mollard
Keyword(s):  
Arginine Vasopressin ◽  
Cytosolic Calcium ◽  
Calcium Signals
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