Investigating T Cell Receptor Signals In Situ by Two-Photon Microscopy of Thymocytes Expressing Genetic Reporters in Low-Density Chimeras

2020 ◽  
pp. 221-238
Author(s):  
Marilaine Fournier ◽  
Mengqi Dong ◽  
Heather J. Melichar
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Low Density ◽  
Two Photon Microscopy ◽  
Two Photon

In-situ Preferential usage of Vα8 T-Cell Receptor Gene Segments in a Patient with Bullous Pemphigoid

1993 ◽  
Vol 6 (6) ◽  
pp. 827-839 ◽  
Author(s):  
Hélène Michalaki ◽  
Sergio Roman-Roman ◽  
Jean-François Nicolas ◽  
Andréas Mackensen ◽  
Jean Thivolet ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Bullous Pemphigoid ◽  
Receptor Gene ◽  
Cell Receptor ◽  
T Cell Receptor Gene ◽  
Cell Receptor Gene

scholarly journals T cell receptor alpha chain genes are located on chromosome 14 at 14q11-14q12 in humans.

1985 ◽  
Vol 161 (5) ◽  
pp. 1255-1260 ◽  
Author(s):  
N Caccia ◽  
G A Bruns ◽  
I R Kirsch ◽  
G F Hollis ◽  
V Bertness ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Chromosome 14 ◽  
Receptor Alpha ◽  
Alpha Chain ◽  
Human T Cell ◽  
Receptor Alpha Chain ◽  
Cell Receptor Alpha

A cDNA clone encoding the alpha chain of the human T cell receptor was used in connection with somatic cell human-rodent hybrids to determine that the genes coding for the alpha chain are located on chromosome 14 in humans. In situ hybridization confirms this result and further localizes these genes to 14q11-14q12 on this chromosome. Since this region of chromosome has been shown to be nonrandomly involved in a number of T cell neoplasias, this assignment raises a number of interesting questions as to the possible involvement of the T cell receptor alpha chain genes in tumorigenesis.

In Situ Analysis of T Cell Receptor Signals during Positive Selection

2017 ◽  
pp. 17-39 ◽  
Author(s):  
Nathalie Labrecque ◽  
Mengqi Dong ◽  
Aditi Sood ◽  
Heather J. Melichar
Keyword(s):  
T Cell ◽  
Positive Selection ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
In Situ Analysis
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