Model for Studying the Effects of Chronic Metabolic Disease on Endogenous Bone Marrow Stem Cell Populations

2020 ◽  
pp. 119-134
Author(s):  
Yashar Mehrbani Azar ◽  
Maria Jacoba Kruger ◽  
Dalene de Swardt ◽  
Michelle Maartens ◽  
Ascentia Mathapelo Seboko ◽  
...  
Keyword(s):  
Metabolic Disease ◽  
Bone Marrow ◽  
Stem Cell ◽  
Bone Marrow Stem Cell ◽  
Cell Populations ◽  
Stem Cell Populations ◽  
Marrow Stem Cell

A Study of the Interdependence of Red Cell and Bone Marrow Stem Cell Populations

1968 ◽  
Vol 15 (1) ◽  
pp. 23-34 ◽  
Author(s):  
J. S. Orr ◽  
J. Kirk ◽  
Kathleen G. Gray ◽  
J. R. Anderson
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Bone Marrow Stem Cell ◽  
Cell Populations ◽  
Red Cell ◽  
Stem Cell Populations ◽  
Marrow Stem Cell

scholarly journals The development of autoimmunity in C57BL/6 lpr mice correlates with the disappearance of natural killer type 1-positive cells: evidence for their suppressive action on bone marrow stem cell proliferation, B cell immunoglobulin secretion, and autoimmune symptoms.

1993 ◽  
Vol 177 (1) ◽  
pp. 155-164 ◽  
Author(s):  
K Takeda ◽  
G Dennert
Keyword(s):  
Bone Marrow ◽  
Cell Proliferation ◽  
Stem Cell ◽  
Natural Killer ◽  
Bone Marrow Stem Cell ◽  
Cell Populations ◽  
Stem Cell Proliferation ◽  
Marrow Stem Cell ◽  
Endogenous Stem Cell

F1 hybrid mice are able to acutely reject parental marrow grafts, a phenomenon that is due to natural killer type 1-positive (NK1+) cells. Circumstantial evidence had suggested that the antigenic determinants recognized by these cells are self-antigens, leading to the hypothesis that the physiological role of NK1+ cells is a downregulatory or suppressive function on bone marrow stem cell proliferation and lymphocyte function. In analyzing this hypothesis it is shown here that in young mice there is a temporal correlation between appearance of NK1+ cells in the spleen and the ability to reject allogeneic marrow or to suppress endogenous stem cell proliferation. The reverse situation exists in mice expressing the homozygous lpr gene. Whereas in young mice cells with NK1+ phenotype are demonstrable, these cells disappear with age, i.e., at the time autoimmunity develops. Concomitant with the disappearance of NK1+ cells, the ability to reject marrow grafts and to control endogenous stem cell proliferation also vanishes. The suggestion that the development of autoimmunity is causally related to the disappearance of NK1+ cells is supported by experiments in which NK1+ cells were either eliminated by antibody injection or increased by adoptively transferring cell populations enriched for NK1+ cells into lpr mice. It is shown that removal of cells enhances autoimmunity, whereas injection of NK1+ cells delays the onset of autoimmunity. In vitro assays are presented that demonstrate that suppression of autoantibody-secreting B cells is due to two NK1+ cell populations, one that expresses CD3 and causes specific suppression and one that lacks CD3 and causes nonspecific suppression.

Effect of Conditioned Medium and Bone Marrow Stem Cell Lysate on the Course of Acetaminophen-Induced Liver Failure

2015 ◽  
Vol 159 (1) ◽  
pp. 118-123 ◽  
Author(s):  
M. Sh. Khubutiya ◽  
A. A. Temnov ◽  
V. A. Vagabov ◽  
A. N. Sklifas ◽  
K. A. Rogov ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Liver Failure ◽  
Conditioned Medium ◽  
Bone Marrow Stem Cell ◽  
Cell Lysate ◽  
Marrow Stem Cell

Mesenchymal bone marrow stem cell secretion: is it immunosuppressive or pro-inflammatory?

2021 ◽  
pp. 171-175
Author(s):  
M. V. Kiselevsky ◽  
◽  
R. Ya. Vlasenko ◽  
N. G. Stepanyan ◽  
I. Zh. Shubina ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Bone Marrow Stem Cell ◽  
Cell Secretion ◽  
Marrow Stem Cell

Wanderings of the bone-marrow stem cell

The Lancet ◽  
2001 ◽  
Vol 358 (9275) ◽  
pp. 5-6 ◽  
Author(s):  
Ken Bradstock
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Bone Marrow Stem Cell ◽  
Marrow Stem Cell

Cognitive Processing Among Mothers of Children Undergoing Bone Marrow/Stem Cell Transplantation

2004 ◽  
Vol 66 (1) ◽  
pp. 92-103 ◽  
Author(s):  
Katherine N. DuHamel ◽  
Sharon Manne ◽  
Nancy Nereo ◽  
Jamie Ostroff ◽  
Richard Martini ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Cognitive Processing ◽  
Bone Marrow Stem Cell ◽  
Marrow Stem Cell
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