Faculty Opinions recommendation of The bone marrow stem cell niche grows up: mesenchymal stem cells and macrophages move in.

2012 ◽  
Author(s):  
Ajay Chawla
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Stem Cell Niche ◽  
Bone Marrow Stem Cell ◽  
Cell Niche ◽  
Marrow Stem Cell

scholarly journals Twisting the bone marrow stem cell niche

Haematologica ◽  
2018 ◽  
Vol 103 (12) ◽  
pp. 1937-1939
Author(s):  
Haixia Niu ◽  
Jose A. Cancelas
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Stem Cell Niche ◽  
Bone Marrow Stem Cell ◽  
Cell Niche ◽  
Marrow Stem Cell

Do microRNAs regulate bone marrow stem cell niche physiology?

Gene ◽  
2012 ◽  
Vol 497 (1) ◽  
pp. 1-9 ◽  
Author(s):  
S.K. Laine ◽  
T. Hentunen ◽  
T. Laitala-Leinonen
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Stem Cell Niche ◽  
Bone Marrow Stem Cell ◽  
Cell Niche ◽  
Marrow Stem Cell

scholarly journals Hemmule: A Novel Structure with the Properties of the Stem Cell Niche

2020 ◽  
Vol 21 (2) ◽  
pp. 539
Author(s):  
Vitaly Vodyanoy ◽  
Oleg Pustovyy ◽  
Ludmila Globa ◽  
Randy J. Kulesza ◽  
Iryna Sorokulova
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Stem Cell ◽  
Stem Cell Niche ◽  
Hematopoietic Stem ◽  
Novel Structure ◽  
Hematopoietic Stem Cell Niches ◽  
Cell Niche ◽  
Stem Cell Niches ◽  
Rat Bone

Stem cells are nurtured and regulated by a specialized microenvironment known as stem cell niche. While the functions of the niches are well defined, their structure and location remain unclear. We have identified, in rat bone marrow, the seat of hematopoietic stem cells—extensively vascularized node-like compartments that fit the requirements for stem cell niche and that we called hemmules. Hemmules are round or oval structures of about one millimeter in diameter that are surrounded by a fine capsule, have afferent and efferent vessels, are filled with the extracellular matrix and mesenchymal, hematopoietic, endothelial stem cells, and contain cells of the megakaryocyte family, which are known for homeostatic quiescence and contribution to the bone marrow environment. We propose that hemmules are the long sought hematopoietic stem cell niches and that they are prototypical of stem cell niches in other organs.

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