Detection of C3 Nephritic Factor by Hemolytic Assay

2021 ◽  
pp. 147-158
Author(s):  
Melchior Chabannes ◽  
Véronique Frémeaux-Bacchi ◽  
Sophie Chauvet
Keyword(s):  
Nephritic Factor ◽  
C3 Nephritic Factor ◽  
Hemolytic Assay

scholarly journals C4 nephritic factor in patients with immune-complex-mediated membranoproliferative glomerulonephritis and C3-glomerulopathy

2019 ◽  
Vol 14 (1) ◽  
Author(s):  
Nóra Garam ◽  
Zoltán Prohászka ◽  
Ágnes Szilágyi ◽  
Christof Aigner ◽  
Alice Schmidt ◽  
...  
Keyword(s):  
Immune Complex ◽  
Membranoproliferative Glomerulonephritis ◽  
Alternative Pathway ◽  
Classical Pathway ◽  
Complement Alternative Pathway ◽  
Nephritic Factor ◽  
C3 Nephritic Factor ◽  
Hemolytic Assay ◽  
Stage Renal Disease ◽  
End Stage

Abstract Background Acquired or genetic abnormalities of the complement alternative pathway are the primary cause of C3glomerulopathy(C3G) but may occur in immune-complex-mediated membranoproliferative glomerulonephritis (IC-MPGN) as well. Less is known about the presence and role of C4nephritic factor(C4NeF) which may stabilize the classical pathway C3-convertase. Our aim was to examine the presence of C4NeF and its connection with clinical features and with other pathogenic factors. Results One hunfe IC-MPGN/C3G patients were enrolled in the study. C4NeF activity was determined by hemolytic assay utilizing sensitized sheep erythrocytes. Seventeen patients were positive for C4NeF with lower prevalence of renal impairment and lower C4d level, and higher C3 nephritic factor (C3NeF) prevalence at time of diagnosis compared to C4NeF negative patients. Patients positive for both C3NeF and C4NeF had the lowest C3 levels and highest terminal pathway activation. End-stage renal disease did not develop in any of the C4NeF positive patients during follow-up period. Positivity to other complement autoantibodies (anti-C1q, anti-C3) was also linked to the presence of nephritic factors. Unsupervised, data-driven cluster analysis identified a group of patients with high prevalence of multiple complement autoantibodies, including C4NeF. Conclusions In conclusion, C4NeF may be a possible cause of complement dysregulation in approximately 10–15% of IC-MPGN/C3G patients.

Quantitation of C3 nephritic factor of alternative complement pathway by an enzyme-linked immunosorbent assay

1987 ◽  
Vol 105 (1) ◽  
pp. 119-125 ◽  
Author(s):  
Jin Seino ◽  
Kazuo Fukuda ◽  
Yasumichi Kinoshita ◽  
Katsuhiko Sudo ◽  
Ikuo Horigome ◽  
...  
Keyword(s):  
Immunosorbent Assay ◽  
Alternative Complement Pathway ◽  
Enzyme Linked Immunosorbent Assay ◽  
Complement Pathway ◽  
Nephritic Factor ◽  
C3 Nephritic Factor ◽  
Alternative Complement

Hypocomplementemic Proliferative Glomerulonephritis with C3 Nephritic-Factor-Like Activity in Multiple Myeloma

Nephron ◽  
1989 ◽  
Vol 52 (3) ◽  
pp. 231-237 ◽  
Author(s):  
Edmund Bourke ◽  
Wallace G. Campbell, Jr. ◽  
Margaret Piper ◽  
Irene J. Check
Keyword(s):  
Multiple Myeloma ◽  
Proliferative Glomerulonephritis ◽  
Nephritic Factor ◽  
C3 Nephritic Factor

C3 NEPHRITIC FACTOR IN A PATIENT WITH RECURRENT NEISSERIA MENINGITIDIS INFECTIONS

2009 ◽  
Vol 92C (1-6) ◽  
pp. 341-349 ◽  
Author(s):  
B. TEISNER ◽  
P. ELLING ◽  
S.-E. SVEHAG ◽  
LENE POULSEN ◽  
L. U. LAMM ◽  
...  
Keyword(s):  
Neisseria Meningitidis ◽  
Nephritic Factor ◽  
C3 Nephritic Factor

Hereditary angio-oedema and C3 nephritic factor-HL-A study

1979 ◽  
Vol 9 (5) ◽  
pp. 527-533 ◽  
Author(s):  
C. SEIGNALET ◽  
F. BERTHOUX ◽  
J. SEIGNALET ◽  
F. B. MICHEL
Keyword(s):  
Nephritic Factor ◽  
C3 Nephritic Factor

scholarly journals A new and specific enzyme-linked immunosorbent assay for the detection of C3 nephritic factor.

1985 ◽  
Vol 147 (1) ◽  
pp. 111-112 ◽  
Author(s):  
JIN SEINO ◽  
KAZUO FUKUDA ◽  
YASUMICHI KINOSHITA ◽  
KATSUHIKO SUDO ◽  
IKUO HORIGOME ◽  
...  
Keyword(s):  
Immunosorbent Assay ◽  
Enzyme Linked Immunosorbent Assay ◽  
Specific Enzyme ◽  
Nephritic Factor ◽  
C3 Nephritic Factor

Recurrent Bacterial Infections Associated with C3 Nephritic Factor and Hypocomplementemia

1983 ◽  
Vol 308 (19) ◽  
pp. 1138-1141 ◽  
Author(s):  
Kathryn M. Edwards ◽  
Robert Alford ◽  
Henry Gewurz ◽  
Carolyn Mold
Keyword(s):  
Bacterial Infections ◽  
Nephritic Factor ◽  
C3 Nephritic Factor
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