Hypocomplementemic Proliferative Glomerulonephritis with C3 Nephritic-Factor-Like Activity in Multiple Myeloma

Nephron ◽  
1989 ◽  
Vol 52 (3) ◽  
pp. 231-237 ◽  
Author(s):  
Edmund Bourke ◽  
Wallace G. Campbell, Jr. ◽  
Margaret Piper ◽  
Irene J. Check
Keyword(s):  
Multiple Myeloma ◽  
Proliferative Glomerulonephritis ◽  
Nephritic Factor ◽  
C3 Nephritic Factor

scholarly journals Alteration of C3 Nephritic Factor in a Patient with Membrano- proliferative Glomerulonephritis Type II

Nephron ◽  
1995 ◽  
Vol 69 (1) ◽  
pp. 114-115 ◽  
Author(s):  
Jin Seino ◽  
Mitsuyoshi Narita ◽  
Hiroo Noshiro ◽  
Kazuto Sato ◽  
Hiroshi Sato ◽  
...  
Keyword(s):  
Proliferative Glomerulonephritis ◽  
Type Ii ◽  
Nephritic Factor ◽  
C3 Nephritic Factor

scholarly journals CHARACTERISTICS OF A NON-COMPLEMENT-DEPENDENT C3-REACTIVE COMPLEX FORMED FROM FACTORS IN NEPHRITIC AND NORMAL SERUM

1970 ◽  
Vol 131 (6) ◽  
pp. 1306-1324 ◽  
Author(s):  
Enrique H. Vallota ◽  
Judith Forristal ◽  
Roger E. Spitzer ◽  
Neil C. Davis ◽  
Clark D. West
Keyword(s):  
Immune Complexes ◽  
Biological Significance ◽  
Normal Serum ◽  
Proliferative Glomerulonephritis ◽  
Temperature Sensitive ◽  
Cobra Venom Factor ◽  
Nephritic Factor ◽  
C3 Nephritic Factor ◽  
Optimum Ph ◽  
Reactive Complex

When serum from a patient with membrano-proliferative glomerulonephritis and normal serum are mixed at 37°C, C3 is rapidly broken down to two more rapidly migrating components. In the mixture, a heat-labile pseudoglobulin, designated as the C3 nephritic factor or C3NeF, reacts with a pseudogolbulin in the normal serum, designated as cofactor, to form a C3 inactivator. By analogy with the cobra venom factor, the C3 inactivator is most likely a complex of the nephritic factor and cofactor. The complex has been designated as the C3 lytic nephritic factor or C3LyNeF. The reaction which results in the Formation of C3LyNeF requires the presence of Mg++, is highly temperature sensitive but occurs very rapidly at 37°C. In 20 min at 37°C, C3LyNeF can break down over 80% of the C3 in a mixture of normal and nephritic serum. The two-step reaction which leads to C3 breakdown has an optimum pH ranging from 6.0 to 9.0. Experiments employing serum depleted of C4 and C2, as well as certain characteristics of the C3NeF system provide evidence that C3 breakdown with nephritic serum is not dependent on complement-inactivating immune complexes or on the action of convertase (C4, 2). Data relating rate of C3 breakdown to the concentrations of C3NeF, C3, and C3LyNeF in the reaction mixture are similar to those for the reaction of enzyme with substrate. The biological significance of C3LyNeF in the production of glomerular inflammation has not been established.

Herpes Gestationis Associated With the C3 Nephritic Factor

1980 ◽  
Vol 116 (9) ◽  
pp. 1045 ◽  
Author(s):  
Ronald Grimwood
Keyword(s):  
Nephritic Factor ◽  
C3 Nephritic Factor ◽  
Herpes Gestationis

Detection of C3 Nephritic Factor by Hemolytic Assay

2021 ◽  
pp. 147-158
Author(s):  
Melchior Chabannes ◽  
Véronique Frémeaux-Bacchi ◽  
Sophie Chauvet
Keyword(s):  
Nephritic Factor ◽  
C3 Nephritic Factor ◽  
Hemolytic Assay

Quantitation of C3 nephritic factor of alternative complement pathway by an enzyme-linked immunosorbent assay

1987 ◽  
Vol 105 (1) ◽  
pp. 119-125 ◽  
Author(s):  
Jin Seino ◽  
Kazuo Fukuda ◽  
Yasumichi Kinoshita ◽  
Katsuhiko Sudo ◽  
Ikuo Horigome ◽  
...  
Keyword(s):  
Immunosorbent Assay ◽  
Alternative Complement Pathway ◽  
Enzyme Linked Immunosorbent Assay ◽  
Complement Pathway ◽  
Nephritic Factor ◽  
C3 Nephritic Factor ◽  
Alternative Complement

C3 NEPHRITIC FACTOR IN A PATIENT WITH RECURRENT NEISSERIA MENINGITIDIS INFECTIONS

2009 ◽  
Vol 92C (1-6) ◽  
pp. 341-349 ◽  
Author(s):  
B. TEISNER ◽  
P. ELLING ◽  
S.-E. SVEHAG ◽  
LENE POULSEN ◽  
L. U. LAMM ◽  
...  
Keyword(s):  
Neisseria Meningitidis ◽  
Nephritic Factor ◽  
C3 Nephritic Factor

Hereditary angio-oedema and C3 nephritic factor-HL-A study

1979 ◽  
Vol 9 (5) ◽  
pp. 527-533 ◽  
Author(s):  
C. SEIGNALET ◽  
F. BERTHOUX ◽  
J. SEIGNALET ◽  
F. B. MICHEL
Keyword(s):  
Nephritic Factor ◽  
C3 Nephritic Factor

scholarly journals A new and specific enzyme-linked immunosorbent assay for the detection of C3 nephritic factor.

1985 ◽  
Vol 147 (1) ◽  
pp. 111-112 ◽  
Author(s):  
JIN SEINO ◽  
KAZUO FUKUDA ◽  
YASUMICHI KINOSHITA ◽  
KATSUHIKO SUDO ◽  
IKUO HORIGOME ◽  
...  
Keyword(s):  
Immunosorbent Assay ◽  
Enzyme Linked Immunosorbent Assay ◽  
Specific Enzyme ◽  
Nephritic Factor ◽  
C3 Nephritic Factor
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