Mutant Mice and Animal Models of Airway Allergic Disease

2021 ◽  
pp. 59-74
Author(s):  
Julyanne Brassard ◽  
David Marsolais ◽  
Marie-Renee Blanchet
Keyword(s):  
Animal Models ◽  
Allergic Disease ◽  
Mutant Mice

Mutant Mice and Animal Models of Airway Allergic Disease

2014 ◽  
pp. 295-308 ◽  
Author(s):  
Marie-Renée Blanchet ◽  
Matthew Gold ◽  
Kelly M. McNagny
Keyword(s):  
Animal Models ◽  
Allergic Disease ◽  
Mutant Mice

ANIMAL MODELS: EC Boosts Funds for Mutant Mice

Science ◽  
2001 ◽  
Vol 292 (5524) ◽  
pp. 1985b-1987
Author(s):  
M. Balter
Keyword(s):  
Animal Models ◽  
Mutant Mice

Functional iron deficiency in toxic milk mutant mice (tx-J) despite high hepatic ferroportin: a critical role of decreased GPI–ceruloplasmin expression in liver macrophages

Metallomics ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 1079-1092 ◽  
Author(s):  
Aneta Jończy ◽  
Paweł Lipiński ◽  
Mateusz Ogórek ◽  
Rafał Radosław Starzyński ◽  
Daria Krzysztofik ◽  
...  
Keyword(s):  
Animal Models ◽  
Iron Deficiency ◽  
Missense Mutation ◽  
Wilson Disease ◽  
Critical Role ◽  
Mutant Mice ◽  
Functional Iron Deficiency ◽  
Liver Macrophages

Jackson toxic milk mutant mice (tx-J) carrying a missense mutation in the Atp7b gene are animal models of the Wilson disease.

Reductionist thinking and animal models in neuropsychiatric research

2019 ◽  
Vol 42 ◽  
Author(s):  
Nicole M. Baran
Keyword(s):  
Animal Models ◽  
Mental Disorders ◽  
Environmental Factors ◽  
Neuropsychiatric Disorders ◽  
Model Organisms ◽  
Developmental Genetic ◽  
Term Study ◽  
Genetic And Environmental Factors ◽  
Mechanisms Of Plasticity

AbstractReductionist thinking in neuroscience is manifest in the widespread use of animal models of neuropsychiatric disorders. Broader investigations of diverse behaviors in non-model organisms and longer-term study of the mechanisms of plasticity will yield fundamental insights into the neurobiological, developmental, genetic, and environmental factors contributing to the “massively multifactorial system networks” which go awry in mental disorders.

New insights into heparan sulphate biosynthesis from the study of mutant mice

2002 ◽  
Vol 69 ◽  
pp. 47-57 ◽  
Author(s):  
Catherine L. R. Merry ◽  
John T. Gallagher
Keyword(s):  
Growth Factors ◽  
Biosynthetic Pathway ◽  
Heparan Sulphate ◽  
Mutant Mice ◽  
Gene Products ◽  
Multiple Gene ◽  
Adhesion Proteins ◽  
Ligand Interactions

Heparan sulphate (HS) is an essential co-receptor for a number of growth factors, morphogens and adhesion proteins. The biosynthetic modifications involved in the generation of a mature HS chain may determine the strength and outcome of HS–ligand interactions. These modifications are catalysed by a complex family of enzymes, some of which occur as multiple gene products. Various mutant mice have now been generated, which lack the function of isolated components of the HS biosynthetic pathway. In this discussion, we outline the key findings of these studies, and use them to put into context our own work concerning the structure of the HS generated by the Hs2st-/- mice.

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