Postnatal Maturation and Experience-Dependent Plasticity of Inhibitory Circuits in Barrel Cortex

2009 ◽  
pp. 91-111
Author(s):  
Qian-Quan Sun
Keyword(s):  
Barrel Cortex ◽  
Postnatal Maturation ◽  
Dependent Plasticity ◽  
Inhibitory Circuits

scholarly journals Genomewide Analysis of Rat Barrel Cortex Reveals Time- and Layer-Specific mRNA Expression Changes Related to Experience-Dependent Plasticity

2011 ◽  
Vol 31 (16) ◽  
pp. 6140-6158 ◽  
Author(s):  
A. Valles ◽  
A. J. Boender ◽  
S. Gijsbers ◽  
R. A. M. Haast ◽  
G. J. M. Martens ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Barrel Cortex ◽  
Dependent Plasticity ◽  
Specific Mrna

Experience-dependent plasticity induced by whisker trimming in thalamocortical responses of slices obtained from the mouse barrel cortex

2007 ◽  
Vol 58 ◽  
pp. S158
Author(s):  
Kenji Watanabe ◽  
Daiki Kamatani ◽  
Ryuichi Hishida ◽  
Masaharu Kudoh ◽  
Katsuei Shibuki
Keyword(s):  
Barrel Cortex ◽  
Dependent Plasticity

Neonatal capsaicin treatment modulates experience-dependent plasticity in the rat barrel cortex

2010 ◽  
Vol 518 (17) ◽  
pp. 3427-3438 ◽  
Author(s):  
Vahid Sheibani ◽  
Ali Shamsizadeh ◽  
Mohammad Reza Afarinesh ◽  
Mohammad Erahim Rezvani
Keyword(s):  
Barrel Cortex ◽  
Dependent Plasticity

scholarly journals Circuit Analysis of Experience-Dependent Plasticity in the Developing Rat Barrel Cortex

Neuron ◽  
2003 ◽  
Vol 38 (2) ◽  
pp. 277-289 ◽  
Author(s):  
Gordon M.G Shepherd ◽  
Thomas A Pologruto ◽  
Karel Svoboda
Keyword(s):  
Barrel Cortex ◽  
Circuit Analysis ◽  
Dependent Plasticity ◽  
Developing Rat

scholarly journals Biphasic impact of prenatal inflammation and macrophage depletion on the wiring of neocortical inhibitory circuits

2019 ◽  
Author(s):  
Morgane Sonia Thion ◽  
Coralie-Anne Mosser ◽  
Isabelle Férézou ◽  
Pauline Grisel ◽  
Sofia Baptista ◽  
...  
Keyword(s):  
Neurodevelopmental Disorders ◽  
Barrel Cortex ◽  
Functional Integration ◽  
Developmental Trajectory ◽  
Inhibitory Circuits ◽  
Cortical Interneurons ◽  
Immune Challenges ◽  
Prenatal Inflammation ◽  
The Impact

SUMMARYThe etiology of neurodevelopmental disorders is linked to defects in Parvalbumin (PV)-expressing cortical interneurons and to prenatal immune challenges. Mouse models of maternal immune activation (MIA) and microglia deficits increase the postnatal density of PV interneurons, raising the question of their functional integration. Here, we show that MIA and embryonic depletion of macrophages including microglia, have a two-step impact on PV interneurons wiring onto their excitatory target neurons in the barrel cortex. In adults, both challenges reduced the inhibitory drive from PV interneurons, as reported in neurodevelopmental disorders. In juveniles, however, we found an increased density of PV neurons, an enhanced strength of unitary connections onto excitatory cells and an aberrant horizontal inhibition with a reduced lateral propagation of sensory inputs in vivo. Our results provide a novel framework for understanding the impact of prenatal immune challenges onto the developmental trajectory of inhibitory circuits that leads to pathological brain wiring.

scholarly journals Molecular signature and target-specificity of inhibitory circuits formed by Martinotti cells in the mouse barrel cortex

2021 ◽  
Author(s):  
Cristina Donato ◽  
Carolina Cabezas ◽  
Andrea Aguirre ◽  
Joana Lourenço ◽  
Marie-Claude Potier ◽  
...  
Keyword(s):  
Cognitive Functions ◽  
Barrel Cortex ◽  
Functional Expression ◽  
Molecular Signature ◽  
Brain Diseases ◽  
Connectivity Pattern ◽  
Biophysical Properties ◽  
Molecular Fingerprint ◽  
Inhibitory Circuits ◽  
Sensory Evoked

AbstractIn the neocortex, fast synaptic inhibition orchestrates both spontaneous and sensory-evoked activity. GABAergic interneurons (INs) inhibit pyramidal neurons (PNs) directly, modulating their output activity and thus contributing to balance cortical networks. Moreover, several IN subtypes also inhibit other INs, forming specific disinhibitory circuits, which play crucial roles in several cognitive functions. Here, we studied a homogeneous subpopulation of somatostatin (SST)-positive INs, the Martinotti cells (MCs) in layer 2/3 of the mouse barrel cortex (both sexes). MCs are a prominent IN subclass inhibiting the distal portion of PN apical dendrites, thus controlling dendrite electrogenesis and synaptic integration. Yet, it is poorly understood whether MCs inhibit other elements of the cortical circuits, and the connectivity properties with non-PN targets are unknown. We found that MCs have a strong preference for PN dendrites, but they also considerably connect with parvalbumin (PV)-positive, vasoactive intestinal peptide (VIP)-expressing and layer 1 (L1) INs. Remarkably, GABAergic synapses from MCs exhibited clear cell-type-specific short-term plasticity. Moreover, whereas the biophysical properties of MC-PN synapses were consistent with distal dendritic inhibition, MC-IN synapses exhibited characteristics of fast perisomatic inhibition. Finally, MC-PN connections used α5-containing GABAARs, but this subunit was not expressed by the other INs targeted by MCs. We reveal a specialized connectivity blueprint of MCs within different elements of superficial cortical layers. In addition, our results identify α5-GABAARs as the molecular fingerprint of MC-PN dendritic inhibition. This is of critical importance, given the role of α5-GABAARs in cognitive performance and their involvement in several brain diseases.Significance statementMartinotti cells (MCs) are a prominent subclass of SST-expressing GABAergic INs, specialized in controlling distal dendrites of PNs and taking part in several cognitive functions. Here we characterize the connectivity pattern of MCs with other INs in the superficial layers (L1 and L2/3) of the mouse barrel cortex. We found that the connectivity pattern of MCs with PNs as well as PV, VIP and L1 INs exhibit target-specific plasticity and biophysical properties. The stark specificity of α5-GABAARs at MC-PN synapses, and the lack or functional expression of this subunit by other cell types, define the molecular identity of MC-PN connections and the exclusive involvement of this outstanding inhibitory circuits in α5-dependent cognitive tasks.

Experience-dependent plasticity of dendritic spines in the developing rat barrel cortex in vivo

Nature ◽  
2000 ◽  
Vol 404 (6780) ◽  
pp. 876-881 ◽  
Author(s):  
Balazs Lendvai ◽  
Edward A. Stern ◽  
Brian Chen ◽  
Karel Svoboda
Keyword(s):  
Dendritic Spines ◽  
Barrel Cortex ◽  
Dependent Plasticity ◽  
Developing Rat

scholarly journals Ipsilateral Whiskers Suppress Experience-Dependent Plasticity in the Barrel Cortex

2007 ◽  
Vol 27 (14) ◽  
pp. 3910-3920 ◽  
Author(s):  
S. Glazewski ◽  
B. L. Benedetti ◽  
A. L. Barth
Keyword(s):  
Barrel Cortex ◽  
Dependent Plasticity
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